At a distal portion of a shaft of a guide portion included in a medical device, a first portion is configured to be capable of coming into contact with an inner wall of a living organ. A second portion is disposed on a proximal side of the shaft with respect to the first portion. The second position is configured to be capable of coming into contact with the inner wall of the living organ at a position different from that of the first portion on a transverse cross section of the inner wall of the living organ. A treatment portion is movable in a lumen of the shaft in a state where at least a part of the first portion and at least a part of the second portion come into contact with the inner wall of the living organ.

The present application provides an electrode catheter system, comprising an interventional catheter for intervening to one side of an artery blood vessel and provided with an electrode element that can release an electrical signal toward an inner wall of a renal artery blood vessel; a pressure sensor for intervening to an artery blood vessel; and a data processing module, connected with the pressure sensor. The electrode element releases an electrical signal toward the inner wall of the renal artery vessel, and then the pressure sensor monitors a blood pressure change in the renal artery vessel at the other side. A data processing module processes the data monitored by the pressure sensor and determines the blood pressure change, and an activity degree of the nerve can be determined by measuring a signal such as the blood pressure of the human body, so as to screen out the patients with an overactive sympathetic nerve, and a surgical effect of a denervation surgery can also be evaluated before or after the surgery, and can be used to determine whether to perform an ultrasonic ablation again.

System and method for locating and identifying nerves innervating the wall of arteries such as the renal artery are disclosed. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The method includes at least the steps to evaluate a change in physiological parameters after energy is delivered to an arterial wall; and to determine the type of nerve that the energy was directed to (none, sympathetic or parasympathetic) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using this method. Also provided are catheters for performing the mapping and ablating functions.

A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate. This cannulated needle is robotically controlled to provide motion into and out of the subject's skull. A flexible needle is disposed coaxially within the cannulated needle, and it is controlled to move into and out of a non-axial aperture in the distal part of the cannulated needle. Coordinated control of the insertion motion of the cannulated and flexible needles, and rotation of the combined cannulated/flexible needle assembly enables access to be obtained to a volume of a region of the brain having lateral dimensions substantially larger than the width of the cannulated needle.

A patient interface device (PID) for contacting the surface of the eye and having a meniscus inverter. A pin, clip and ridge configuration for holding a window and maintaining an open reservoir of BSS in a PID. A PID for integrated systems and methods for performing laser and phacoemulsification operations. A PID for a reconfigurable system for performing a laser procedure in a laser configuration, and then being reconfigured into a phaco configuration, to perform a phacoemulsification, and then being reconfigured back to the laser configuration.

Systems, devices, and methods involve ablation of tissue to treat rhinitis and/or other nasal conditions. Implementations allow treatment of tissue in the confined space of the nasal cavity. Additionally, implementations allow targeted treatment tissue to be ablated, while protecting other non-treatment tissue from unintentional collateral effects that might be produced by the ablation. According to an example implementation, an approach for treating a nasal condition includes advancing a probe into a nasal cavity, the probe including a shaft and a cryotherapy element coupled to the shaft. The approach also includes cryogenically cooling a target treatment site with the cryotherapy element to treat at least one nasal nerve. Additionally, the approach includes transmitting a focused ultrasound beam to a target heating site to increase a temperature tissue at the target heating site.

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves that do not converge and do not diverge. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

The present invention, in some embodiments thereof, relates to methods and/or apparatus for measuring the effectiveness of a renal denervation treatment. In some embodiments, a method for determining effectiveness of the denervation treatment comprises tracking at least one of arterial wall movement, arterial blood flow rate, arterial blood flow velocity, blood pressure and arterial diameter at one or more selected locations in the renal artery over time, and assessing the effectiveness of said renal denervation treatment according to results obtained by tracking.

This invention provides a device for mapping and ablating the renal nerves distributed on renal artery, having a guide catheter, a mapping-ablation catheter, a handle and a connector. The guide catheter has at least one lumen and a distal end with adjustable curvature. The mapping-ablation catheter is housed in one of the lumens of the guide catheter and its distal end has one or more electrodes and one or more detecting devices. The distal end of the mapping-ablation catheter is curved, rotatable, and can be extended out of or retracted into the guide catheter. The handle connects the guide catheter and mapping-ablation catheter, and has one or more controlling components for controlling the movement of the guide catheter and mapping-ablation catheter. The connector is designed to supply energy to the electrodes.