The invention comprises a charged particle cancer therapy system used to seal a periphery of a tumor, such as through use of a proton or carbon ion beam searing the outer edges of the tumor, which prevents/hinders nutrient delivery to the tumor resultant in stunted growth of the tumor, halted growth of the tumor, and/or starvation/necrosis of the tumor. Optionally, a tumor sealing layer is formed using multiple passes, of a treatment beam of the charged particle cancer therapy system, across a tumor/healthy tissue boundary layer or voxel.

A particle therapy system includes a particle accelerator to output a particle beam; and a scanning system for the particle accelerator to scan the particle beam across at least part of an irradiation target. The scanning system is configured to scan the particle beam in two dimensions that are at an angle relative to a direction of the particle beam. A structure defines an edge. The structure is controllable to move in the two dimensions relative to the irradiation target such that at least part of the structure is between at least part of the particle beam and the irradiation target. The structure includes a material that inhibits transmission of the particle beam.

A particle therapy system includes a particle accelerator to output a particle beam; and a scanning system for the particle accelerator to scan the particle beam across at least part of an irradiation target. The scanning system is configured to scan the particle beam in two dimensions that are at an angle relative to a direction of the particle beam. A structure defines an edge. The structure is controllable to move in the two dimensions relative to the irradiation target such that at least part of the structure is between at least part of the particle beam and the irradiation target. The structure includes a material that inhibits transmission of the particle beam.

In a beam transport system, based on a beam temporal-variation related amount that has been calculated by a beam analyzer and that is a beam-position temporal variation amount or a beam diameter at a beam profile monitor, an optical parameter calculator calculates a start-point momentum dispersion function that is a momentum dispersion function (, ) of a charged particle beam at a start point in design of the beam transport system that is set on a beam trajectory of the accelerator; and calculates optical parameters using, as an initial condition, the start-point momentum dispersion function and a beginning condition at an irradiation position at the time of detecting profile data.

Systems and methods for relative optimized linearization (ROL) for radiochromic film (RCF) dosimetry may eliminate the need for dose-response curve measurements while incorporating non-uniformity corrections. The ROL method may include, for each of multiple color channels, determining linearization parameters that minimize a cost function that evaluates an error between expected and calculated doses. The ROL method may use the linearization parameters to generate a variation map including dose-independent variation values and use the variation map to determine a corrected net optical density of the RCF. The ROL method may use the linearization parameters and the corrected net optical density to produce a dose image including corrected doses.