Applications of dielectric barrier discharge (DBD) based atmospheric pressure plasma jets are often limited by the relatively small area of treatment due to their 1D configuration. This system generates 2D plasma jets permitting fast treatment of larger targets. DBD evolution starts with formation of transient anode glow, and continues with development of cathode-directed streamers. The anode glow can propagate as an ionization wave along the dielectric surface through and outside of the discharge gap. Plasma propagation is not limited to 1D geometry such as tubes, and can be organized in a form of a rectangular plasma jet, or other 2D or 3D shapes. Also described are a method for generating 2D plasma jets and use of the 2D plasma jets for cancer therapy.

A single non-thermal atmospheric plasma generation device is used to detect and analyze vital fields of a living subject to determine the presence of a condition, such as an illness or injury, and responsively modify characteristics of the plasma to treat, heal, or alleviate the condition. The device includes a capacitance dielectric discharge array of plasma emitters, and a controller having a power supply, a transformer, and circuit components for driving the transformer at a resonant frequency of the plasma emitters to cause the plurality of plasma emitters to ionize surrounding air and produce the non-thermal plasma. The resonant frequency is around 60 GHz and harmonics thereof. A receiver of the device recovers frequency mixing products from the plasma, which are extracted by signal processing circuitry; signals in the VHF and UHF bands are extracted and analyzed to determine whether signatures of particular vital fields are present.

An elongate electrode is configured to flex and generate plasma to incise tissue. An electrical energy source operatively coupled to the electrode is configured to provide electrical energy to the electrode to generate the plasma. A tensioning element is operatively coupled to the elongate electrode. The tensioning element can be configured to provide tension to the elongate electrode to allow the elongate electrode to flex in response to the elongate electrode engaging the tissue and generating the plasma. The tensioning element operatively coupled to the flexible elongate electrode may allow for the use of a small diameter electrode, such as a 5 μm to 20 μm diameter electrode, which can allow narrow incisions to be formed with decreased tissue damage. In some embodiments, the tensioning of the electrode allows the electrode to more accurately incise tissue by decreasing variations in the position of the electrode along the incision path.

A plasma for prevention of intraepithelial neoplasia, particularly by anti-viral therapy. The plasma may be used, for example, against the human papillomavirus, for treatment of intraepithelial neoplasia of all grades of severity, e.g., carcinoma in situ lesions, and/or for treatment of invasive carcinoma that is reachable in epithelial manner. A system for creating the plasma includes a medical instrument with at least one electrode having galvanic contact to the plasma. The medical instrument also has an RF device that provides an alternating voltage to supply the instrument with electric power and a gas supply device that is adjusted to supply gas, for example argon gas, to the instrument.

The disclosure relates to a device for treatment of skin, mucous membranes or body parts with a cold atmospheric pressure plasma by generating a dielectric barrier surface discharge, including a flexible insulating material, a flexible high-voltage electrode, a flexible dielectric, a flexible grounded electrode, a gas supply, wherein the flexible high-voltage electrode is embedded between the flexible insulating material and the flexible dielectric, wherein the grounded electrode is applied on a surface of the flexible dielectric that is configured to face a curved surface of a body part to be treated, wherein the flexible high-voltage electrode, the flexible dielectric and the flexible grounded electrode of the device form a flexible layered arrangement for providing the cold atmospheric pressure plasma, wherein the arrangement forms a hollow spherical body with a closed volume and wherein a plasma can be ignited for treating the curved surface with the cold atmospheric pressure plasma.

A system for generating cold plasma is presented, suitable for use in in-vivo treatment of biological tissue. The system comprising: a control unit connectable to an elongated member at a first proximal end of the elongated member. The elongated member comprises a plasma generating unit at a second distal end thereof and gas and electricity transmission channels extending from said first proximal end towards said plasma generating unit. The control unit comprises a gas supply unit configured to provide predetermined flow rate of selected gas composition through said gas transmission channel and a power supply unit configured to generate selected sequence of high-frequency electrical pulses, typically in mega Hertz range, directed through said electricity transmission channel, thereby providing power and gas of said selected composition to the plasma generating unit for generating cold plasma.

An integrated gas-enhanced electrosurgical generator. The generator comprises a high frequency power module, a low frequency power module and a gas module. The high frequency power module adapted to generate an electrical energy having a band of frequencies centered around a first frequency, wherein the electrical energy has a first power as the first frequency and a second power lower than the first power at a second frequency lower than the first frequency. The low frequency power module having an input connected to an output of the high frequency module. The low frequency module comprises a resonant transformer comprising a ferrite core, a primary coil and a secondary coil, the secondary coil having a larger number of turns than the primary coil, wherein the resonant transformer has a resonant frequency equal to the second frequency. The gas module is adapted to control a flow of an inert gas.

A treatment apparatus which uses thermal or non-thermal plasma to treat urinary tract infections (UTIs) by destroying bacteria. The apparatus comprises an elongate probe that includes a coaxial cable for conveying radiofrequency (RF) electromagnetic (EM) energy and/or microwave EM energy, a probe tip connected at the distal end of the coaxial cable for receiving the RF and/or microwave EM energy, and a gas conduit for conveying gas to the probe tip. The probe tip comprises a first electrode connected to the inner conductor of the coaxial cable, and a second electrode connected to the outer conductor of the coaxial cable, and wherein the first electrode and second electrode are arranged to produce an electric field from the received RF and/or microwave EM energy across a flow path of gas received from the gas conduit to produce a thermal or a non-thermal plasma.

A plasma treatment device configured for a treatment within the oral cavity of a living organism using a dielectric barrier plasma, comprising a high-voltage stage (5, 6) arranged in a housing and serving for generating high-voltage signals required for generating the plasma, and comprising an electrode arrangement (10), which is connected to the high-voltage stage and is covered by a dielectric (9) for forming a dielectric barrier plasma, enables various treatments in the oral cavity of the living organism in a simple manner by virtue of the fact that the housing has a handle part (1), to which a head part (2) is secured in a releasable and exchangeable manner by means of a mechanical connection arrangement, in that the handle part (1) contains all stages required for generating the high-voltage signals and a contact arrangement, at which the high-voltage signals are present, in that the head part (2) is embodied in a shape specific to a specific treatment and has a corresponding shaped electrode arrangement (10), which is surrounded completely by the dielectric (9) and has a terminal (14), which makes contact with the contact arrangement of the handle part (1) when the head part (2) is secured to the handle part (1) in a manner effected by means of the mechanical connection arrangement.

An apparatus or device for performing cold atmospheric plasma procedures. The device or apparatus has a housing, a chamber within the housing, an entry port to the chamber, a plurality of exit ports from the chamber, and a plurality of electrodes mounted in the housing, each of the plurality of electrodes having a distal end adjacent one of the plurality of exit ports. The entry port, chamber, exit ports and plurality of electrodes are configured to provide for an inert gas flowing in the entry port and through the chamber to the exit port to become plasmatized by electrical energy applied to the plurality of electrodes to form a cold plasma flowing from the exit ports.