A method of coating frame sealant and device are disclosed, to coat areas having different shapes and widths with the frame sealant. The method of coating frame sealant comprises the steps of dividing an area to be coated with frame sealant on a display panel into different subareas based on a contour of the area, the subareas comprising a linear-type subarea to be coated with the frame sealant and a curve-type subarea to be coated with the frame sealant; providing a coating instruction for each subarea to be coated with the frame sealant among the different subareas; and coating the frame sealant to the subarea according to the coating instruction.