Provided herein is a catheter assembly including an imaging device for identifying an anatomical structure. The catheter assembly includes a patient cannula configured to be drawn along a catheter or guide wire; a transseptal puncture catheter at least partially enclosed within the patient cannula; and an imaging catheter. The imaging catheter includes a transducer configured to emit an energy beam capable of reflecting from an anatomical structure and to detect energy reflected from the structure. The catheter assembly also includes a transmitter for conveying a signal representative of the detected energy from the transducer to a signal processor for obtaining information about the structure. An imagining system and a method for identifying a predetermined transseptal puncture location on an atrial septum are also provided herein.

Devices, systems, and methods for stent detection and apposition are disclosed. Embodiments obtain a plurality of images of intravascular image data of a vessel wall and an endovascular device, generate a signal that represents the plurality of images, identify one or more images that correspond to the endovascular device based on the signal that represents the plurality of images, generate a representation of a three-dimensional (3D) shape of the endovascular device based on the one or more images, determine an apposition value of the endovascular device relative to the vessel wall using a representation of a 3D shape of a lumen segment that corresponds to the endovascular device, the apposition value based on a volume difference between the 3D shape of the lumen segment and the 3D shape of the endovascular device, and present information indicating the apposition value.

The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.

A method of quantifying progression of pregnancy, includes a) illuminating a uterine cervix with polarized light having a wavelength comprised between 600 and 1100 nm; b) acquiring a plurality of images of the illuminated uterine cervix through a polarization state analyser in respective analysing states; steps a) and b) being performed either once or a plurality of time using polarized light having different polarization states; c) from the acquired images, computing a depolarization parameter over a region of interest of the uterine cervix; and d) quantifying the progression of the pregnancy from said depolarization parameter. An apparatus, based on a colposcope fitted with a controllable polarization state generator, a controllable polarization state analyser and a suitably-programmed computer, for carrying out such a method. A computer program for carrying out such a method.

A tracer detection device includes an enclosed body, and a plurality of tracer sensors, a battery, a memory, and a transmitter, each disposed within the enclosed body. The plurality of tracer sensors is configured to detect measurement values at a surface and underneath the surface of a gastrointestinal tract. The battery is configured to power the plurality of tracer sensors. The memory is configured to receive measurement values detected by the plurality of tracer sensors. The transmitter is configured to transmit measurement values detected by the plurality of tracer sensors to an external device after the enclosed body has passed through the gastrointestinal tract. The enclosed body includes a steering feature that ensures the enclosed body is oriented in an intended direction. The plurality of tracer sensors triggers release of a drug. The plurality of tracer sensors estimate distances to gastrointestinal walls for normalizing signals.

The present invention provides compositions and methods for imaging tumor resections.

Embodiments of the present invention may be used to perform measurement of surfaces, such as external and internal surfaces of the human body, in full-field and in 3-D. Embodiments of the present invention may include an electromagnetic radiation source, which may be configured to project electromagnetic radiation onto a surface. The electromagnetic radiation source may be configured to project the electromagnetic radiation in a pattern corresponding to a spatial signal modulation algorithm. The electromagnetic radiation source may also be configured to project the electromagnetic radiation at a frequency suitable for transmission through the media in which the radiation is projected. An image sensor may be configured to capture image data representing the projected pattern. An image-processing module may be configured to receive the captured image data from the image sensor and to calculate a full-field, 3-D representation of the surface using the captured image data and the spatial signal modulation algorithm. A display device may be configured to display the full-field, 3-D representation of the surface.

A system for monitoring vital signs, configured to be used in conjunction with a computerized mobile device, the system including: a cover sensor assembly adapted to be operably engaged with the computerized mobile device, the cover sensor assembly having integrated therein at least one physiological sensor; a physiological data acquisition module configured to generate a physiological parameter measurement descriptive of a physical stimulus received by the at least one physiological sensor; and a validation module configured to control a validity status of the physiological parameter measurement.

Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.

A device for insertion into soft tissue including a micro electrode, a micro light source; a stiffening element having a material dissolvable or degradable in aqueous body fluid or a material swellable in such fluid to form a transparent gel; a coat of a flexible non-conducting polymer material on the stiffening element; a base disposed at the rear end of the device. The flexible coat has a distal opening allowing light emitted from the light source to leave the device upon said collapse or dissolution or swelling. Also disclosed is a therapeutic or diagnostic device formed in the tissue from the insertable device, uses thereof, and a method of disposing the insertable device in soft tissue.