A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle. The control circuitry can be further configured to operate the one or more pressurizing elements to generate coordinated pressure modifications in the left atrium, and optionally the pulmonary artery.

An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example.

Systems and methods for epicardial electrophysiology and other procedures are provided in which conditions at the location of an access needle may be determined according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject, and the pressure frequency information may be segmented based on the cardiac waveform information. Conditions at the current location of the needle may be determined based on an algorithm including the segmented pressure frequency information and the cardiac waveform information.

An intravascular rotary blood pump possesses a catheter (10), a pumping device (50) disposed distally of the catheter and having at its distal end a flexible flow cannula (53) through which blood is either sucked or discharged by the pumping device (50) during operation of the blood pump, and at least one pressure sensor (27, 28A, 30) having at least one optical fiber (28A) which is laid along the flow cannula (53). The optical fiber (28A) and, where applicable, a sliding tube (27) in which the optical fiber (28A) is laid extend along a neutral fiber of the flow cannula (53).

An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector, a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interlace; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.

A pressure sensing medical device may include a guidewire including a tubular member having a lumen, the tubular member being translatable between a generally straightened position and a deflected position, and a pressure sensor attached at a distal end of a fiber optic extending within the lumen, the pressure sensor being disposed within a distal portion of the tubular member. The pressure sensor may include a pressure-sensitive membrane disposed on a distal end thereof. The pressure sensor may include one or more contact members capable of providing a contact point between the contact member and an inner surface of the tubular member when in the deflected position, the contact point being axially spaced apart from the membrane along a longitudinal axis of the pressure sensor.

The invention is directed to systems and methods for determining a fundamental pulse wave velocity value for a vessel with minimized effect of reflections originating from the vessel network connected distal to the respective vessel.

An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example.

An example method includes detecting, via a sensor, vibrations originating from a vein of a subject and obtaining an intensity spectrum of the detected vibrations over a range of frequencies. The method further includes using the obtained intensity spectrum to determine a metric selected from a group that includes: a pulmonary capillary wedge pressure (PCWP), a mean pulmonary arterial pressure, a pulmonary artery diastolic pressure, a left ventricular end diastolic pressure, a left ventricular end diastolic volume, a cardiac output, total blood volume, and a volume responsiveness of the subject. An example computing device and an example non-transitory computer readable medium that are related to the method are disclosed as well.

A system for assessing a vascular condition includes a pressure sensing catheter and a pressure guidewire. Heartbeats of the patient can be detected while the pressure sensing catheter and the pressure guidewire are positioned at the proximal position and at a distal position respectively. A diastolic pressure ratio zone (dPR zone) is located within a heartbeat from analysis of a signal from at least one of the pressure sensing catheter and the pressure guidewire. The dPR value can be obtained by calculating an average of several ratios of Pa to Pd taken over time within the heartbeat. A multi-beat metric (dPRc) is calculated that includes the dPR value and that also includes a high frequency sample whole heartbeat pressure ratio.