Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent. In some embodiments, the devices, systems, and methods of the present disclosure are configured to optimize proximal and distal pressure measurements utilized to assess the vessel.

A system and method for evaluating blood flow in a vessel of a patient includes a catheter containing a first pressure sensor and a second pressure sensor and configured to simultaneously measure pressure data within a vessel on either side of a stenosis. Pressure data generated by the catheter includes a first series of pressure measurements from the first pressure sensor a second series of pressure measurements from the second pressure sensor. The system and method further includes a fractional flow reserve (FFR) calculation module executable on one or more processors and configured to calculate a stability index for each of two or more portions of the pressure data, wherein each stability index indicates at least one of heart rate stability and catheter stability for the respective portion of the pressure data. An optimal time window is identified based on the stability indexes for calculation of FFR based on the pressure data. A FFR value is then calculated based on the pressure data in the optimal time window.

Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.

Impedance systems and methods of use. The impedance systems include only one electrode positioned upon an elongate body, and at least two external electrodes. The only one electrode is configured to both excite an electric field and detect the electric field. The only one electrode works with a first external electrode to generate an electric field and works with a second external electrode to obtain conductance measurements from the electric field. In other embodiments the first external electrode and/or the second external electrode may also be configured to both excite an electric field and detect the electric field. In other embodiments, both the first external electrode and the second external electrode can work with the only one electrode to both generate an electric field and obtain at least one conductance measurement.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and/or regulate a temperature of the bodily fluid flowing therethrough.

A vascular graft includes a flexible substrate that can assume an unrolled configuration, in which the substrate extends along a main extension plane, and a rolled-up configuration, in which a first side of the substrate is facing radially inward and a second sideof the substrate is facing radially outward. At least one pressure sensing device is arranged on the first side of the substrate and includes a first electrode, a second electrode, and a piezoelectric element arranged between the two electrodes. At least one velocity sensing device is arranged on the first side of the substrate and a first electrode, a second electrode, and a piezoelectric element arranged between the electrodes. The graft can be used in a vascular graft system.

A surgical instrument includes a handle portion, a shaft coupled to the handle portion, a pair of jaw members operably coupled to the shaft, an inflatable member, and a sensor. The inflatable member is associated with one of the jaw members and is configured to apply pressure to tissue disposed between the pair of jaw members. The sensor is associated with one of the jaw members and is configured to measure local perfusion pressure in the tissue disposed between the pair of jaw members.

A measuring apparatus includes: a measuring section which performs an invasive blood pressure measurement, and which detects that a predetermined abnormal condition occurs in a blood pressure during the measurement; a detector which detects whether or not a zero point calibration is being executed on a transducer to be used in the measurement; and a notification controller which, in a case where the blood pressure measured by the measuring section is in the predetermined abnormal condition, controls whether an alarm is output or not, based on a detection state of the detector. The notification controller can select a first mode in which an alarm sound is output, or a second mode in which the alarm sound is not output, based on an elapsed time period from a predetermined timing relating to the zero point calibration, and an output from the measuring section.

The present technology relates to interatrial shunting systems and methods. In some embodiments, the present technology includes interatrial shunting systems that include a shunting element having a lumen extending therethrough that is configured to fluidly couple the left atrium and the right atrium when the shunting element is implanted in a patient. The system can also include an energy receiving component for receiving energy from an energy source positioned external to the body, an energy storage component for storing the received energy, and/or a flow control mechanism for adjusting a geometry of the lumen.

A method and a medical elongate body are configured to prevent stagnation or turbulence of blood flow in a recess of a rugged pattern formed in a blood vessel due to bulging of a blood vessel wall at a lesion part of the blood vessel. The method involves partitioning an inside of the blood vessel into upstream and downstream sides of the recess, and introducing gel into the recess to at least partially fill the recess. A blood vessel lumen forming method and medical elongate body to form such a lumen are other aspects of the disclosure and involve introducing gel into the recess to at least partially fill the recess with the gel, and drilling the gel to remove at least some of the gel to form a passage and secure blood flow in the blood vessel.