Described here are wireless monitoring devices, systems, and methods for estimating one or more physiological parameters of a patient. These devices and systems may measure or receive a signal waveform transmitted through one or more of fluid and a physiological structure of a patient. This measured signal waveform may be processed to generate waveform parameter data used to estimate a physiological parameter such as blood velocity, heart wall thickness, and the like.

Methods, systems, and devices are disclosed for administering one or more medications useful for facilitating diagnostic and/or surgical procedures within a patient. A guidewire is positioned intravascularly in a patient at a location of interest, the guidewire being free of any coating that includes adenosine. An intravascular component having a surface with a coating that includes a vasodilation agent is deployed over the guidewire. The vasodilation agent is released from the surface of the intravascular component, such as by eluting the vasodilation agent from the coating of the surface while the intravascular component is within the anatomical structure of the patient. The intravascular component is removed over the guidewire, and the guidewire is left at the location of interest after the intravascular component is removed, which can facilitate subsequent deployment of a different intravascular component over the guidewire.

The present invention provides for an improved combination sensor tip that includes an ultrasound transducer and a pressure sensor both disposed at or in close proximity to the distal end of the combination sensor tip. The present invention also provides for an improved connector to couple a guide wire to a physiology monitor that reduces torsional resistance when maneuvering the guide wire.

An intravascular sensor system including an array of pressure and/or temperature sensors for detecting pressure and/temperature. In one example, the sensors are interrogated with an optical catheter. In this example, the swept source is able to acquire both image and pressure/temperature data of a patient's vessel or artery. In another example, the intravascular pressure sensor system has a sheath embedded with pressure sensors in the sheath wall. Other examples include the process of making and using the intravascular pressure sensor system.

The present disclosure relates generally to the assessment and treatment of vessels, including for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). For example, some embodiments of the present disclosure are suited for identifying the available intervention technique(s) suitable to achieve a desired outcome selected or input by a user. For example, in some implementations a method comprises receiving pressure measurements obtained by one or more intravascular pressure-sensing instruments positioned within a vessel of a patient; receiving an input from a user regarding a desired pressure value for the vessel of the patient; identifying an available treatment option based on the received pressure measurements and the desired pressure value; and outputting, to a display device, a screen display including a visual representation of the available treatment option. Related devices and systems are also described.

A vascular graft includes deformable sleeves that include an electrical component. The electrical component can be variable-resistance or piezoelectric, in embodiments, such that deformation of the sleeves due to pressure changes create or modify an electrical signal. A transponder can then transmit information relating to the pressure inside and outside of the vascular graft.

Systems, devices, and methods for obtaining fractional flow reserve in the presence of a catheter. In a method of determining a fractional flow reserve in the presence of a catheter, the method comprises the steps of obtaining measurements of an inner luminal organ diameter proximal to, at, and distal to a stenosis and a length of the stenosis, obtaining a pressure drop measurement at the stenosis, calculating a volumetric flow of fluid through the inner luminal organ at the stenosis, and determining a stenotic pressure drop at the stenosis corresponding to dimensions of the guidewire as a function of the calculated volumetric flow of fluid through the inner luminal organ at the stenosis, wherein the stenotic pressure drop is indicative of a fractional flow reserve at or near the stenosis.

Assemblies are provided comprising a stent and a sensor positioned on and/or in the stent. Within certain aspects the sensors are wireless sensors, and include for example one or more fluid pressure sensors, contact sensors, position sensors, accelerometers, pulse pressure sensors, blood volume sensors, blood flow sensors, blood chemistry sensors, blood metabolic sensors, mechanical stress sensors and/or temperature sensors. Within certain aspects these stents may be utilized to assist in stent placement, monitor stent function, identify complications of stent treatment, monitor physiologic parameters and/or medically image a body passageway, e.g., a vascular lumen.

Devices, systems, and methods for auto-retroperfusion of the cerebral venous system. In an exemplary embodiment of a catheter for controlling blood perfusion pressure of the present disclosure, the catheter comprises a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen and adapted to move between an expanded configuration and a deflated configuration, and at least one sensor coupled with the distal end of the body, each of the at least one sensors adapted to gather data relating to a fluid flowing through the lumen, wherein the catheter is configured to be coupled to a flow unit for regulating the flow and pressure of a fluid.

A system for determining a pulse velocity wave comprises an interface for receiving a signal indicating the proximal blood pressure in an artery and for receiving a signal indicating distal blood pressure in the artery. A processing device is configured to determine a proximal rising edge between a diastolic pressure and the systolic pressure of the proximal signal; determine a proximal pressure peak prior to the proximal rising edge; determine a distal rising edge between a diastolic pressure and a systolic pressure of the distal signal; determine a distal pressure peak prior to the distal rising edge and to determine whether the distal pressure peak is in phase advance with respect to the proximal pressure peak; and determine a propagation velocity of a regressive pulse wave depending on the phase advance of the distal pressure peak.