The present disclosure relates to a method and a system for modelling a human heart and/or chambers and cavities therein, such as the left and right atrium, based on a plurality of emission tomography images, such as positron emission images, of said human heart, wherein each image represents concentrations of a tracer that has been injected at a specific time, the overall method comprising the steps of: A: extracting time activity curves of a tracer that has been injected for a plurality of pixels and/or voxels; B: identifying first-pass peaks of the time activity curves, each peak corresponding to an arrival time of the injected tracer at the corresponding pixel/voxel; C: defining a model comprising at least two portions of the heart, wherein the at least two portions are isolated by selecting pixels and/or voxels based on comparisons of the first-pass peaks against a threshold; and D: arranging the at least two portions in relation to each other by comparing the arrival times of the first-pass peaks of the pixels and/or voxels in the portions, thereby obtaining a segmented model of the human heart, which method and model may specifically be used to obtain an estimate of the volume of the left or right atrium of said human heart.

The present invention provides an in vivo imaging method that facilitates the diagnosis of Acute Lymphoblastic Leukemia (ALL) at an early stage. Early diagnosis is particularly advantageous as a tool to select more aggressive therapy, to estimate the success rate for visualizing ALL at the time of diagnosis.

A family of catheter electrode assemblies includes a flexible circuit having a plurality of electrical traces and a substrate; a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the electrode. A non-contact electrode mapping catheter includes an outer tubing having a longitudinal axis, a deployment member, and a plurality of splines, at least one of the plurality of splines comprising a flexible circuit including a plurality of electrical traces and a substrate, a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the ring electrode. A method of constructing the family of catheter electrode assemblies is also provided.

Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries utilizing external imaging.

The present invention provides a closed loop generation and/or infusion system comprising a radionuclide generator, an activity detector, a controller, a dose calibrator, a pump, eluant source and an automated elution system controlled by software and hardware for generation and infusion of a radionuclide for administering a dose of generated radionuclide into a subject for diagnosing a peripheral arterial disease in a subject suffering from or suspected of suffering from peripheral arterial disease and/or metabolic disease via Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies. More particularly, the present invention provides methods of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease by performing quantitative assessment of blood flow in lower extremities or limbs of the subject: wherein the quantitative assessment is performed by analyzing one or more images and providing a severity score: and wherein the analysis of the one or more images is performed by using an automated system.

A family of catheter electrode assemblies includes a flexible circuit having a plurality of electrical traces and a substrate; a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the electrode. A non-contact electrode mapping catheter includes an outer tubing having a longitudinal axis, a deployment member, and a plurality of splines, at least one of the plurality of splines comprising a flexible circuit including a plurality of electrical traces and a substrate, a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the ring electrode. A method of constructing the family of catheter electrode assemblies is also provided.

A microangiography method and system based on full-space modulation spectrum splitting and angle compounding is disclosed. Label-free three-dimensional optical coherence tomography angiography is realized by combining the three-dimensional space resolution capability of an optical coherence tomography and the motion recognition capability of a dynamic scattering technology. Probe light of different incident angles is encoded with a transverse scanning modulation spectrum in a spatial frequency domain, incident angle-resolved sub-angiograms which are independent of one another are obtained by splitting the modulation spectrum, and an angiogram with multiple space angles compounded is realized. Conjugate mirror images are removed from a depth (z) domain, a complex-valued OCT interference spectra are reconstructed, the full-space modulation spectrum is obtained in the spatial frequency domain, and the overlap of the modulation spectrum conjugate mirror images is avoided. And the absolute flow velocity of blood flow can be measured through a multi angle-resolved probing technology.

An image processing apparatus includes a processing circuitry. The processing circuitry acquires volume data including a blood vessel image. The processing circuitry generates volume data indicating a blood vessel image on a basis of the acquired volume data. The processing circuitry generates three-dimensional image data indicating a blood vessel image of a region corresponding to a predetermined dominance region of dominance regions, on a basis of the volume data indicating the blood vessel image.

The disclosed embodiments relate to a system that performs ultra-fast tracer imaging on a subject using positron emission tomography. During operation, the system performs a high-temporal-resolution, total-body dynamic PET scan on the subject as an intravenously injected radioactive tracer propagates through the vascular system of the subject to produce PET projection data. Next, the system applies an image reconstruction technique to the PET projection data to produce subsecond temporal frames, which illustrate the dynamic propagation of the radioactive tracer through the vascular system of the subject. Finally, the system outputs the temporal frames through a display device.

A family of catheter electrode assemblies includes a flexible circuit having a plurality of electrical traces and a substrate; a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the electrode. A non-contact electrode mapping catheter includes an outer tubing having a longitudinal axis, a deployment member, and a plurality of splines, at least one of the plurality of splines comprising a flexible circuit including a plurality of electrical traces and a substrate, a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the ring electrode. A method of constructing the family of catheter electrode assemblies is also provided.