Embodiments of the presently-disclosed subject matter include methods and systems for measuring a level of a neurotransmitter in a subject. Embodiments of the present methods comprise displaying a fixation point, a reward target, and a non-reward target, and measuring one or more saccade movement parameters for reward saccades and non-reward saccades. The saccade movement parameters can include velocity, amplitude, reaction time, or a combination thereof. The present methods can further include determining a reward modulation of the subject, the reward modulation being equal to a difference between the reward and the non-reward values for a respective saccade movement parameter. Some embodiments further include identifying the subject as including a deficiency of the neurotransmitter if there is a statistically measurable difference between the reward modulation of the subject and a reference reward modulation and/or if the non-reward and the reward saccade movement parameters are statistically equivalent.

An oral appliance includes: 1) a body defining a channel to accommodate an upper dentition; and 2) a motion sensor. The body includes a front portion defining a recess, and the motion sensor is affixed to the front portion.

Numerous aspects of communication devices, methods, and systems are described in this application. One aspect is an apparatus comprising a plurality of energy generators arrangeable on or adjacent skin. Each energy generator of the plurality of energy generators may be operable to output a plurality of different energy types in a signal direction toward the skin. The plurality of energy generators may be operable to communicate with nerves associated with the skin when arranged on or adjacent the skin by outputting an energy signal in the signal direction with one or more energy types of the plurality of different energy types.

A device is provided for the stimulation of neurons that includes a non-invasive stimulation unit to generate stimuli in multiple stimulation channels, where the stimulation unit stimulates a neuron population in the brain and/or spinal cord of a patient in different locations for each of the stimulation channels. Moreover, the device includes a control unit that controls the stimulation unit to generate repetitive bursts in each of the stimulation channels, where each of the bursts includes multiple stimuli and is designed so that they do not reset the phase of the neuronal activity of the respective stimulated neurons.

Embodiments regard nutrition assessment using a handheld device. An embodiment of an apparatus includes a handle with a controller within the handle, an attachment arm extending from the handle, and a user-assistive device coupled with an end of the attachment arm, wherein the apparatus is to determine a mass held by the user-assistive device, the determination being made during a task by a user of the handheld tool including manipulation of the handheld tool.

The invention describes a method for identifying alterations in a musculoskeletal system of a subject, wherein the method comprises the steps of associating, with the subject, detecting means capable of detecting physical quantities representative of a state of the subject, detecting the physical quantities through the detecting means, identifying a biomechanical model for the subject, determining combined movements of muscles and bones as a function of said physical quantities detected and of said identified biomechanical model, converting the combined movements into a plurality of movement steps of segments and joints, computing parameters representative of the alterations, comparing the parameters computed with predefined reference values representative of alteration thresholds in the musculoskeletal system, identifying the alterations as a function of a failed matching between the computed parameters and the predefined reference values, and determining the belonging of this correspondence to one or more groups of musculoskeletal pathologies as a function of said identified alteration.

The invention further comprises a system for identifying alterations in a musculoskeletal system of a subject.

This invention is smart clothing with stretch and/or bend sensors for measuring changes in a person's body configuration. This smart clothing has an elastic nonconductive layer onto which helical converging/diverging conductive pathways are printed using ink which is a mixture of elastic nonconductive material and conductive material. Changes in the transmission of electromagnetic energy through the pathway are analyzed to measure changes in the configuration of the person's body.

According to one embodiment, an eye movement detecting device comprises first, second, third, fourth and fifth electrodes. A line connecting the first and the third electrodes passes through the right eye and a line connecting the second and the fourth electrodes passes through the left eye on at least one of a front view, a plan view or a side view. A distance between the fifth and the first electrodes is equal to a distance between the fifth and the second electrodes. A distance between the fifth and the third electrodes is equal to a distance between the fifth and the fourth electrodes. The detector respectively detects a horizontal movement of the right eye and a horizontal movement of the left eye.

The present disclosure provides systems, apparatuses, and methods for use of wearable electrode assemblies. The electrode assemblies improve comfort by providing increased overall surface area of their bottom surfaces, which make contact with the patient's scalp and hair. Collapse, compression, or telescoping of the bottom surface will thereby decrease the direct force and/or pressure applied by the distal member or members of the bottom surfaces to the skin. This may be advantageous in patients who have little to no hair in electrode contact areas, patient populations that are particularly skin-sensitive, and/or patients which must wear the electrode assemblies of an extended time period. The electrode assemblies further include structures to dispense and/or maintain conductive gel placed over the patient's skin, thereby maintaining electrical connection quality, and/or to facilitate the clearing of skin and/or hair prior to establishing an electrical connection.

Technology is disclosed for detecting scratch events and predicting flares of pruritus, utilizing motion data sensed from a wearable sensor. Detecting scratch may be done with a two-tier approach by first detecting a hand motion from motion sensed data and then classifying that hand motion as a scratch event using one or more computerized classification models. Embodiments may focus on detecting nighttime scratch by utilizing motion sensed data captured during a user's detected sleep opportunity. Additionally, historical scratch event data may be used to predict a user's itch and flare risk for a future time interval. Decision support tools in the form of computer applications or services may utilize the detected scratch events or predicted itch or flare risk to initiate an action for reducing current itch and/or mitigating future risk, including initiating a treatment protocol that includes therapeutic agent.