Skin-mounted or epidermal devices and methods for monitoring biofluids are disclosed. The devices comprise a functional substrate that is mechanically and/or thermally matched to skin to provide durable adhesion for long-term wear. The functional substrates allow for the microfluidic transport of biofluids from the skin to one or more sensors that measure and/or detect biological parameters, such as rate of biofluid production, biofluid volume, and biomarker concentration. Sensors within the devices may be mechanical, electrical or chemical, with colorimetric indicators being observable by the naked eye or with a portable electronic device (e.g., a smartphone). By monitoring changes in an individual's health state over time, the disclosed devices may provide early indications of abnormal conditions.

A capsule (220), said capsule (220) having a coupling face (222) configured to be coupled to a complementary shape on a housing (120), and a microneedle array (210) that is positioned on a planar contact surface (229). The coupling face (222) has rotational symmetry about an axis of rotation (Z) which extends orthogonally to the planar surface (229) and about which at least two coupling positions are permitted with a single and unique complementary shape on a housing (120), there being, within a fixed reference frame, no microneedle (210) in the same location as that of a different microneedle (210), in the two positions.

A wearable sensor device comprises a sensor at least part of which is inserted into a human body and which has a first connection terminal; a mount unit on which at least part of the first connection terminal is disposed and which is mounted on a skin of the human body; and an electronic unit that is mounted to the mount unit and has a second connection terminal connected to the first connection terminal via a mounting mechanism, and a control unit for acquiring signals from the sensor. The mounting mechanism forms a first state where the mount unit and the electronic unit are mounted such that the first connection terminal and the second connection terminal have yet to be connected, and a second state where the mount unit and the electronic unit are mounted such that the first connection terminal and the second connection terminal have been connected.

The present invention discloses a non invasive screening system for neonatal Hyperbilirubinemia based on transcutaneous bilirubin (TcB) comprising at least one nail bed transilluminating light source for penetrating subcutaneous tissue from the nail bed of neonatal subject enabling spectral analysis of circulating blood in underneath blood capillaries, a probe means cooperating with said nailbed for desired transilluminating by the selective light source held on the nail bed of the neonatal subject and reflected light collection fibre means operatively connected to spectrometric means for said spectral analysis. The spectrometric means enables identification of markers for bilirubin for desired screening the neonatal Hyperbilirubinemia in the neonatal subjects in complete range of up to 20 mg/dL bilirubin content in the circulating blood through non-invasive screening.

In one or more embodiments, a continuous analyte monitoring wearable device includes a disposable base unit having a power source and an analyte sensor, and a reusable transmitter unit that includes electronic circuitry configured to bias the analyte sensor, measure current through the analyte sensor, and may even compute analyte values based on measured current through the analyte sensor. The disposable base unit is configured to couple to the reusable transmitter unit and supply electrical power to the electronic circuitry of the reusable transmitter unit for continuous analyte monitoring. Numerous other embodiments are provided.

In one or more embodiments, a continuous analyte monitoring wearable device includes a disposable base unit having a power source and an analyte sensor, and a reusable transmitter unit that includes electronic circuitry configured to bias the analyte sensor, measure current through the analyte sensor, and, in some embodiments, even compute analyte values based on measured current through the analyte sensor. The disposable base unit is configured to couple to the reusable transmitter unit and supply electrical power to the electronic circuitry of the reusable transmitter unit for continuous analyte monitoring. Numerous other embodiments are provided.

A biosensor system package includes: a transistor structure in a semiconductor layer having a front side and a back side, the transistor structure comprising a channel region; a buried oxide (BOX) layer on the back side of the semiconductor layer, wherein the buried oxide layer has an opening on the back side of the channel region, and an interface layer covers the back side over the channel region; a multi-layer interconnect (MLI) structure on the front side of the semiconductor layer, the transistor structure being electrically connected to the MLI structure; and a cap structure attached to the buried oxide layer, the cap structure comprising a microneedle.

It is provided a device for non-invasively and continuously extracting interstitial fluid comprising or not comprising an immunogenic compound from the skin of a subject comprising an electroporator generating a non-pulsed voltage coupled to a pulsed voltage between at least one moving electrode and an electrical conducting adhesive for non-heating irreversibly electroporating the skin; a vacuum pump providing a negative pressure above the skin; and a collecting chamber for collecting the interstitial fluid extracted from the skin wherein the device can be used for detecting Covid-19 and/or extracting an antibody produced in the subject.

A wearable sensing device is disclosed. The wearable sensing device includes a plurality of electrodes. A corresponding group of microprobes associated to each of the plurality of electrodes is provided. Each of the microprobes includes a plurality of piercers configured to penetrate the skin of the user.

A wearable sensing device is disclosed. The wearable sensing device includes a plurality of electrodes. A corresponding group of microprobes associated to each of the plurality of electrodes is provided. Another group of microprobe associated with a trigger circuit is provided and configured to determine attachment of the wearable sensing device to the user.