Conventionally, the arterial input function is determined by administering a contrast agent and measuring the responsive magnetic signal in a reference voxel located in a large artery such as the middle cerebral artery. By instead measuring the signal in a voxel of the choroid plexus, a more accurate profile for the arterial input function may be obtained. The metabolic activity in the choroid plexus is negligible, which provides greater certainty for signal sampling.

A concentration measurement apparatus includes a probe being attached to a head and having a light source for outputting measurement light and a photodetection unit for generating a detection signal according to an intensity of incident light, a calculation unit for performing a calculation of a hemoglobin concentration-related numerical value in the head which varies due to repetition of chest compression on the basis of the detection signal according to the intensity of the measurement light propagated through the inside of the head, and an instruction unit for instructing the calculation unit to start the calculation. The photodetection unit continuously generates the detection signal before the calculation start in the calculation unit. The instruction unit determines the calculation start on the basis of the detection signal.

A sensor for evaluating tissue of a subject is provided. The sensor includes a flexible spine disposable on the subject, a flexible member that includes first and second flexible member portions accommodated within the flexible spine, a light source, a detector and a rigid member. The light source is attached to the first flexible member portion and is configured to emit light toward the tissue. The detector is attached to the second flexible member portion and is configured to receive the light having reflected off the tissue. The rigid member is coupled with the first and second flexible member portions. In response to a curvature of the flexible spine, the rigid member moves the first and second flexible member portions along the flexible spine to adjust a distance between the light source and the detector.

A method of evaluating a cerebrovascular health of a patient includes causing a patient to exercise for an exercise duration at an exercise intensity, collecting cerebrovascular information from the patient during the exercise duration, collecting cardiovascular information from the patient during the exercise duration, correlating the cerebrovascular information to the cardiovascular information to create a correlated cerebrovascular curve, and determining a cerebrovascular health and viability for cerebrovascular therapy.

The present disclosure relates to a sensor for monitoring the depth of consciousness of a patient. The sensor includes a plurality of light sources, light detectors, and in some embodiments, electrodes. In an embodiment, the sensor includes reusable and disposable portions.

A regional oximetry pod drives optical emitters on regional oximetry sensors and receives the corresponding detector signals in response. The sensor pod has a dual sensor connector configured to physically attach and electrically connect one or two regional oximetry sensors. The pod housing has a first housing end and a second housing end. The dual sensor connector is disposed proximate the first housing end. The housing at least partially encloses the dual sensor connector. A monitor connector is disposed proximate a second housing end. An analog board is disposed within the pod housing and is in communications with the dual sensor connector. A digital board is disposed within the pod housing in communications with the monitor connector.

Modular physiological sensors that are physically and/or electrically configured to share a measurement site for the comfort of the patient and/or to ensure proper operation of the sensors without interference from the other sensors. The modular aspect is realized by providing outer housing shapes that generally conform to other physiological sensors; mounting areas for attachment of one sensor to another sensor; providing release liners on the overlapping sensor attachment areas; and/or providing notches, tabs or other mechanical features that provide for the proper placement and interaction of the sensors.

A physiological activity detection system comprises a signal acquisition module configured for non-invasively acquiring a signal from an anatomical structure of a user, the acquired signal having a physiological-encoded component and a periodic artifact component that dominates the physiological-encoded component. The physiological activity detection system further comprises a phase-locked loop (PLL) component configured for estimating a phase of the periodic artifact component of the acquired signal, and generating a periodic reference signal having a phase representative of the estimated phase of the periodic artifact component of the acquired signal.

A method includes receiving from a psychological and physiological sensing (PPS) device worn on a subject's head, sensor data from sensors fixed to the PPS device. The sensors may include a left-temple photoplethysmography (PPG) sensor, a right-temple PPG sensor, and an electroencephalogram (EEG) sensor coupled to the subject's head. The right and left temple PPG sensors are configured to detect pulsating blood flow in blood vessels proximal to a left and right temple region. Pulse morphology data of pulses related to the pulsating blood flow from the left-temple PPG signal and the right-temple PPG signal are determined. A possibility of a cardiac dysfunction, a cerebral dysfunction, or both in the subject may be determined based on an EEG signal, a comparison of the pulse morphology data of pulses from the left-temple PPG signal and the right-temple PPG signal, or both.

The present invention relates to an AI (Artificial Intelligence) based device for providing brain information comprising: a brain signal measuring portion that collects a signal related to user's brain; a brain signal stimulating portion that stimulates the user's brain for an operation of collecting a signal of the brain signal measuring portion; and a diagnosing portion that determines the user's brain state on the basis of the collected signal.