A method of determining a parameter related to a blood oxygenation of tissue may include projecting an optical pattern onto the issue, the optical pattern comprising a spatially varying component in at least one axis. A method of determining a parameter related to a blood oxygenation of tissue may include collecting a reflected optical signal from at least a first and a second wavelength range, wherein the first and the second wavelength ranges are distinct. A method of determining a parameter related to a blood oxygenation of tissue may include normalizing the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include performing a transform of the reflected optical signal. A method of determining a parameter related to a blood oxygenation of tissue may include determining the parameter related to the blood oxygenation of the tissue based on the ratio and the transform.

An ophthalmic imaging system provides an automatic focus mechanism based on the difference of consecutive scan lines. The system also provides of user selection of a focus point within a fundus image. A neural network automatically identifies the optic nerve head in an FA or ICGA image, which may be used to determine fixation angle. The system also provides additional scan tables for multiple imaging modalities to accommodate photophobia patients and multi-spectrum imaging options.

A method to image an in vivo object in an eye includes illuminating an object in the eye by a light source; configuring one or more detectors to receive light from a conjugate plane behind a confocal plane of the object, the conjugate plane acting as a light screen; receiving at the one or more detectors a backscattered light from the light source which has been refracted at least in part by the object before being backscattered from the light screen to provide a detector data; and processing the detector data over a time period by a computer to generate information about the object.

An instrument includes: one or more scanning mirrors to receive an OCT sample beam and to scan the sample beam in two orthogonal directions; and an optical system to receive the sample beam and provide the sample beam to an eye. The optical system includes: a first lens having a first focal length, disposed along an optical path from the scanning mirror(s) to the eye at a distance from the cornea which is approximately equal to the first focal length, and a second lens disposed along the optical path between the first lens and the scanning mirror(s). The second lens receives the sample beam from the scanning mirror(s) and provides the sample beam to the first lens as a converging beam such that, as the sample beam is scanned, the sample beam passes through a pivot point located along an optical axis between the eye and the first lens.

A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.

An eyewear device, method for use with an eyewear device, and a non-transient computer readable medium for detecting blood sugar levels are disclosed. The eyewear device has a frame including a first rim configured to support a first lens, a second rim configured to support a second lens, and a bridge connecting the first rim to the second rim. The bridge is configured to receive a nose of a user when the eyewear device is worn by the user. Blood sugar levels are detected by monitoring behavior of a pupil of an eye of the user with a sensor, comparing the monitored behavior with known blood sugar level behaviors, identifying a match responsive to the comparison between the monitored behavior and one of the known blood sugar level behaviors corresponding to a particular blood sugar level, and selecting the particular blood sugar level as a blood sugar level of the user.

In some embodiments, a system comprises a head-mounted frame removably coupleable to the user's head; one or more light sources coupled to the head-mounted frame and configured to emit light with at least two different wavelengths toward a target object in an irradiation field of view of the light sources; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering the target object; and a controller operatively coupled to the one or more light sources and detectors and configured to determine and display an output indicating the identity or property of the target object as determined by the light properties measured by the detectors in relation to the light properties emitted by the light sources.

An augmented reality AR system and method for a retail experience include a waveguide apparatus that includes a planar waveguide and at least one optical diffraction element The AR retail system and method recognizes user location in a retail establishment, retrieves data corresponding to the retail establishment and generates virtual content relating to the retail establishment based on the retrieved data. The AR retail system and method creates a virtual user interface in a user's field of view. Virtual content is displayed on the virtual user interface while the user is engaged in retail activity and may be based on user input. The AR retail system and method may provide entertainment, facilitate the shopping experience, offer virtual coupons, render games based on locations throughout a store or based on a shopping list, provide information about food choices such as calorie counts, and identify metadata associated with items.

An augmented reality AR system and method for a retail experience include a waveguide apparatus that includes a planar waveguide and at least one optical diffraction element The AR retail system and method recognizes user location in a retail establishment, retrieves data corresponding to the retail establishment and generates virtual content relating to the retail establishment based on the retrieved data. The AR retail system and method creates a virtual user interface in a user's field of view. Virtual content is displayed on the virtual user interface while the user is engaged in retail activity and may be based on user input. The AR retail system and method may provide entertainment, facilitate the shopping experience, offer virtual coupons, render games based on locations throughout a store or based on a shopping list, provide information about food choices such as calorie counts, and identify metadata associated with items.

An instrument includes: one or more scanning mirrors to receive an OCT sample beam and to scan the sample beam in two orthogonal directions; and an optical system to receive the sample beam and provide the sample beam to an eye. The optical system includes: a first lens having a first focal length, disposed along an optical path from the scanning mirror(s) to the eye at a distance from the cornea which is approximately equal to the first focal length, and a second lens disposed along the optical path between the first lens and the scanning mirror(s). The second lens receives the sample beam from the scanning mirror(s) and provides the sample beam to the first lens as a converging beam such that, as the sample beam is scanned, the sample beam passes through a pivot point located along an optical axis between the eye and the first lens.