A surgical instrument may be configured to sense a light re-emitting probe to resolve tissue oxygenation, the surgical instrument including: an optical emitter configured to excite the light re-emitting probe within an absorption band of the light re-emitting probe; an optical detector configured to receive the re-emitted light from the probe; and a signal processor configured to resolve the tissue oxygenation based on the received light. The surgical instrument can be a surgical stapler anvil or a flexible substrate having a tissue interfacing surface. Further, a monitoring device may be configured to map oxygenation of a tissue containing a light re-emitting probe, the monitoring device including: an optical emitter configured to excite the light re-emitting probe; at least one optical detector configured to receive the re-emitted light from the probe; and a signal processor that is configured to resolve the tissue oxygenation at multiple points to generate an oxygen map.

An illustrative system may include an imaging device and an image processing system. The imaging device may be configured to output first image information corresponding to a first wavelength band associated with fluorescence emitted by a substance and may be configured to output second image information corresponding to a second wavelength band different from the first wavelength band and associated with the fluorescence emitted by the substance. The image processing system may be configured to receive the first image information and the second image information from the imaging device and may determine, based on a comparison of the first image information to the second image information, a property of the substance.

A contactless system for assessing tissue viability and other hemodynamic parameters includes one or more light sources configured to emit lights at a predetermined wavelength sensitive to hemoglobin concentration associated with spontaneous hemodynamic oscillations at tissue in a predetermined area of a human subject. One or more polarizers are each coupled to one or more of the one or more light sources and are configured to polarize the light to a polarized state such that the polarized light in the polarized state diffuses into the tissue in the predetermined area at a predetermined depth and the polarized light is maintained in the polarized state at the predetermined depth. One or more detectors each including a detector polarizer coupled thereto are configured to discriminate the light maintained in the polarized state and at the predetermined depth and are configured to generate a plurality of frames of the tissue in the predetermined area at the predetermined depth. A controller is coupled to the one or more light sources and the one or more detectors. The controller is configured to: acquire the plurality of frames, select a region of interest having the same coordinates for each of the plurality of frames, average the number of pixels within each region of interest to create a raw reference signal, detrend the raw reference signal to create a detrended raw reference signal, perform frequency domain analysis of the detrended raw reference signal, identify a frequency band of interest associated with the spontaneous hemodynamic oscillations, and perform an inverse fast Fourier transform within the frequency band of interest to generate a reference signal indicative of blood volume oscillations at a selected spontaneous hemodynamic oscillation. For each sample of the reference signal at a predetermined point in time, the controller multiplies the sample by each pixel of a frame at the same predetermined point in time to generate a three-dimensional coordinate matrix including a plurality of correlation matrix frames at each predetermined point in time. The controller adds the plurality of correlation matrix frames at each predetermined point in time to generate a two-dimensional hemodynamic map indicative of the strength of the spontaneous hemodynamic oscillation to assess the viability of the tissue in the predetermined area.

In an embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of an analyte. In an additional embodiment, the present disclosure pertains to an analyte detection system. In some embodiments, the system includes a biosensor operable to be implanted into a media and a transmitter having a light source. In some embodiments, the transmitter is operable to be external to the media and operable to receive photoluminescence outputs back from the biosensor to determine properties of analytes. In a further embodiment, the present disclosure pertains to a biosensor having a plurality of discrete compartments in a barcode configuration.

A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

A water hose coupling having a swivel grip is provided. A first coupling portion with a male threaded end integral with a first larger diameter base is connected to a second coupling portion through a freely rotating connection. The second coupling portion includes a second larger diameter base. The second coupling portion further includes a coupling protrusion integral with the second larger diameter base. The coupling protrusion may have one or more barbs to interface with a hose or a threaded female coupling to interface with a male threaded connector. The coupling is connected to an end of a hose to which accessories may be attached. An outer sleeve is connected to the first larger diameter base of the first coupling portion and can freely rotate with the first coupling portion around the remainder of the apparatus and hose. The outer sleeve acts as an ergonomic grip for users to hold and rotate when using the hose and installing accessories.

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

Apparatus, systems, and methods are provided that generate in vivo maps of oxygenation measurements of biological tissue. These may include surgical instruments and stand-alone imaging systems with incorporated oxygen sensing capability. Oxygenation maps can be determined via fluorescent or phosphorescent lifetime imaging of an injectable probe with an oxygen-dependent optical response. Probe configuration and methods and apparatus of injecting the probe into the tissue are provided. Methods and apparatus for temperature compensation of temperature-dependent lifetime measurements are provided to improve oxygenation measurement accuracy. Oxygen maps may be registered with visible light images to assist in assessing tissue viability or localize anomalies in the tissue. Resulting oxygen images may be used for various applications including, but not limited to, guiding surgical procedures such as colorectal resection through use of intraoperative sensing, enhanced endoscopic imaging for identifying suspect lesions during colonoscopy, and external imaging of tissue such as assessing peripheral vascular disease.

Embodiments described herein relate to a catheter configured to detect at least one blood gas parameter present in blood in an artery of a patient, including, but not limited to, a catheter wall forming at least one lumen configured for umbilical arterial catheterization, at least one optical fiber incorporated in the catheter wall, wherein the at least one optical fiber is configured to detected the at least one blood gas parameter.

An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.