The biological test kit is a device for drawing and, optionally, testing biological samples. The biological test kit is an array of lancets set in wells in a rigid base. Each lancet well is covered by a protective cover which when deformed permits the lancet to puncture a user or other patient. In one embodiment the biological test kit employs distinct covers for each lancet and in another the covers are formed from sheet material formed into blisters which cover the lancet.

A microfluidic device for non-invasively and passively accessing interstitial fluid from a patient includes a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.

Provided are systems and methods for reducing pain during an injection or an insertion of an object into the skin of a subject.

Aspects of the invention provide a biological sample collection pad (e.g., for the collection of fecal, liquid or tissue samples). Method of using such pads and analyzing collected samples are also provided.

An interstitial fluid removal device including a first needle, a second needle, a fluid injector and an interstitial fluid extractor. The first needle is configured for insertion in a tissue of a multicellular organism to provide a fluid inlet channel. The second needle is configured for insertion in a tissue of a multicellular organism to provide an interstitial fluid outlet channel. The fluid injector is arranged in fluid communication with both a fluid source and the first needle and configured to inject a fluid in the tissue of the multicellular organism. The fluid extractor is arranged in fluid communication with the second needle and configured to extract interstitial fluid from the tissue of the multicellular organism. The fluid injector and the fluid extractor are independently and/or simultaneously operable with respect to each other.

Methods, systems, and apparatus, including biological fluid monitoring systems comprising a microneedle layer; at least one electromagnet assembly; and at least two liquid chambers coupled via a microfluidic layer, wherein the microneedle layer comprises a plurality of microneedles configured to extract interstitial fluid (ISF) from a patient in to one of the at least two liquid chambers, and wherein the at least one electromagnet assembly is configured to a move a test sample of the extracted ISF through the at least two liquid chambers to conduct a test cycle.

The disclosed apparatus, systems and methods relate to devices, systems and methods for the collection of bodily fluids. The collector can make use of microfluidic networks connected to collection sites on the skin of a subject to gather and shuttle blood into a removable cartridge. The collected fluid is supplied to substrate for drying, storage and transport.

A blood collection device for the self-collection of a blood sample by a user, wherein, a base element has a width of more than 1.75 in and including an upstanding wall which defines a receive opening, the upstanding wall having a height of less than 1.75 in; a collection container is configured for placement in said receive opening in a substantially upright orientation; the finger portion comprising a blood collection hole that provides a fluid channel between the collection container and the finger portion; wherein at least the base element is a separate part, configured to be shipped in a de-assembled state with respect to the other parts of the blood collection device, wherein the blood collection device is configured to be assembled by a user after receiving said blood collection device.

It is provided a method and devices for detecting kidney failure and dialysis of a subject wherein the epidermis is irreversibly electroporated without generating any heat and a negative pressure is applied forming micro-conduits in the epidermis from which the interstitial fluid can be extracted, analysed and filtered to produce for example a dialysate and returned to the subject.