Provided herein are novel methods and compositions for determining serum analyte levels from biological matrices. The methods disclosed herein include determining a level of a protein in a serum of a patient in need thereof, comprising: (a) perturbing a soft tissue in a mouth of the patient: (b) collecting a sample of fluid from the oral, nasal, or other cavity of the patient; and (c) measuring the level of the protein in the sample of fluid from the cavity of the patient, wherein measuring the level of one or more protein in the sample of fluid from the sample of the patient affords a normalization or calibration curve allowing an accurate measurement of the level(s) of the desired analyte(s) in the serum of the patient.

A fluid collection device for a postpartum hemorrhage monitoring system includes a cup comprising an open proximal end, an open distal end, and an interior extending between the open proximal and distal ends. The interior is configured to receive a fluid. The cup comprises an anterior surface configured for placement adjacent an anterior vaginal wall of a patient and a posterior surface configured for placement adjacent a posterior vaginal wall of a patient. A ring extends radially exteriorly from the open proximal end of the cup and is incrementally expandable and contractible. A stem having an open proximal end, an open distal end, and a lumen extending therebetween, extends between the open distal end of the cup and is configured to receive the bodily fluid from the interior of the cup. The ring is movable between a collapsed configuration to an expanded configuration upon receiving a fluid within the ring.

A device for collection of vaginal discharge or menstrual blood as an analyte of medical testing, comprising a filter configured to separate cells of interest from other material and a nanomaterial cartridge comprising a nanomaterial configured to passively adsorb DNA and segregate cells of different sizes. The nanomaterial is a silica sol gel with templated macropores