An arterial access system includes a catheter assembly having an arterial catheter and an access port. A blood draw device is coupled to the access port, with the blood draw device including a catheter tube, a housing that movably receives the catheter tube and has a distal end portion coupleable to the catheter assembly, and an advancement member configured to move relative to the housing to move the catheter tube between first and second positions to enable a distal end of the catheter tube to be disposed past a distal of the arterial catheter. A collection device is positioned proximal to the housing and in fluid communication with the catheter tube such that, with the catheter tube in the second position, the collection device directly collects a sample of arterial blood through the catheter tube.

A blood draw device for performing arterial blood collection includes a catheter tube, a housing configured to movably receive the catheter tube, and an advancement member movably coupled to the housing to move the catheter tube between first and second positions, with a distal end of the catheter tube disposed beyond a distal end of the housing and past a distal tip of the indwelling arterial catheter when in the second position. A secondary catheter is coupled to the advancement member and extends out proximally therefrom, with a collection device coupled to the secondary catheter so as to be in fluid communication with the catheter tube. The blood draw device is configured such that a fluid path formed by the catheter tube and secondary catheter has a controlled geometric factor, defined as a ratio of a length of the fluid path to an inner diameter of the fluid path.

An apparatus useful for the rapid collection of blood from a subject (e.g., a blood vessel, such as the vein, artery or capillary bed of a bovine subject) and dispensing the blood therefrom into a test or collection device. In general, the apparatus comprises: (a) a body having a chamber formed therein, said chamber having an inlet and outlet, with said chamber configured to draw blood therein; (b) a hollow barrel connected to said chamber outlet; (c) an ejector operatively associated with said barrel; (d) a hollow needle connected to said body, with said hollow needle in fluid communication with said chamber through said inlet, so that blood can be rapidly drawn into said chamber through said needle. The needle is optionally removed and blood dispensed from the body into a test or collection device by actuating the ejector.

An apparatus useful for the rapid collection of blood from a subject (e.g., the vein of a bovine subject) and dispensing the blood therefrom into a collection device includes: (a) a capillary body having a capillary chamber formed therein, with the chamber having an inlet and outlet, and with said chamber configured to draw blood therein through the inlet by capillary action; (b) a hollow barrel connected to the chamber outlet; (c) a plunger positioned in the barrel; and (d) a hollow needle connected to the capillary body, with the hollow needle in fluid communication with the capillary chamber through the capillary inlet, so that blood can be rapidly drawn into the capillary chamber through the needle by the combined action of vein pressure (or other pressure, if present, such as arterial pressure) and capillary action.

The various embodiments described herein relate to fabricating and using open microfluidic networks according to methods, systems, and devices that can be used in applications ranging from home-testing, diagnosis, and research laboratories. Open microfluidic networks allow the input, handling, and extraction of fluids or components of the fluid into or out of the open microfluidic network. Fluids can be inserted into an open microfluidic channel by using open sections of the open microfluidic network. Passive valves can be created in the microfluidic network, allowing the creation of logic circuits and conditional flow and volume valves. The fluid can be presented via the microfluidic network to diagnostic and analysis components. Fluids and components of the fluid can be extracted from the open microfluidic network via functional open sections that are easily interfaced with other microfluidic networks or common laboratory tools.

Provided herein is a blood draw device including a housing defining a housing lumen and an inner volume proximal to the housing lumen, a coupling device, a catheter tube movably received within the housing, and an advancement member movable relative to the housing to move the catheter tube between a first position where the catheter tube is disposed within the housing and a second position where a distal end of the catheter tube is disposed beyond the distal end of the housing. A first port is provided on the housing, in fluid communication with the housing lumen, and a second port is provided proximally from the housing, in fluid communication with the catheter tube. A seal is positioned in the housing lumen proximal to the first port, with the catheter tube proximal to the seal when in the first position and extending through the seal when in the second position.

A tissue penetration device includes a magnetic source that produces a controllable magnetic field in a magnetically active region adjacent the magnetic source. A magnetic member is disposed at least partially in the magnetically active region. A permanent magnet is disposed at a proximal end of the magnetically active region for zeroing the position of the magnetic member while the tissue penetration device is inactive.

The present disclosure relates to coated substrates, capillaries and microfluidic channels which exhibit an extended shelf life compared to uncoated substrates. More specifically the disclosure relates to charged coatings at physiological pH which may prolong the shelf life of the substrate, capillary or microfluidic channel before being applied to biological fluids. Said shelf life is measured by the ability to provide a low fluid contact angle after an extended storage interval in ambient atmospheric conditions.

A device for collecting a liquid sample by capillarity includes distinct first and second elements having respective male and female parts. The male part comprises a channel having a transverse section. The female part comprises a peripheral wall that transversely delimits a cavity to house the male part. A part of the peripheral wall forms a cap to close the transverse section when the female part houses the male part.

A capillary cavity 19 and an inlet 13 protruding circumferentially outward from an axial center 107 are connected by a guide section 17 formed so as to extend circumferentially inward and on which a capillary force acts. A sample liquid collected from a leading end of the inlet 13 is transferred to a separation cavity 23. A bent section 22 and a recess 21 are formed at a connected section of the guide section 17 and the capillary cavity 19 so as to change the direction of a passage.