An apparatus includes a housing, defining an inner volume, and an actuator mechanism movably disposed therein. The actuator mechanism is configured to be transitioned from a first configuration to a second configuration to define a pre-sample reservoir fluidically couplable to receive a pre-sample volume of bodily-fluid via an inlet port of the housing. The actuator mechanism is movable from a first position to a second position within the housing after the pre-sample reservoir receives the pre-sample volume such that the housing and the actuator mechanism collectively define a sample reservoir to receive a sample volume of bodily-fluid via the inlet port. The outlet port is in fluid communication with the sample reservoir and is configured to be fluidically coupled to an external fluid reservoir after the sample volume is disposed in the sample reservoir to transfer at least a portion of the sample volume into the external fluid reservoir.

A blood sampler includes a hollow transparent barrel including a reduced collection portion located at a front end thereof and terminating in a reduced coupling portion, an outlet defined in the coupling portion and a plurality of ribs spaced around and raised from an inside wall near an opposing rear end thereof, a piston axially movably fitted into the hollow transparent barrel and having a screw hole and peripheral ribs, a cap detachably capped onto the collection portion to seal the outlet, and a plunger having a screw rod located at a front end thereof and threaded into the screw hole of the piston for allowing movement the piston with the plunger. The hollow transparent barrel enables collecting blood sample from a patient, separating the collected blood sample into platelet-rich plasma, platelet-rich plasma and serum in a centrifuge and injecting the collected platelet-rich plasma into a patient body.

A medical device having a frontal attachment and a connector housing having or attachable to an associated medical apparatus, the frontal attachment slidably engaging the connector housing and having a forwardly projecting, rearwardly biased needle and a needle retraction assembly, and the connector housing having a needle retraction cavity laterally offset from the needle in a first position, the needle retraction cavity being selectively movable relative to the frontal attachment following use to reposition the needle retraction cavity into alignment with the needle to permit retraction.

A medical device for the separation of a concentrate enriched with cells from a biological fluid, in particular a concentrate of stromal or stem cells from medullar aspirate or venous blood, comprises: a treatment container for receiving and treating the biological fluid for the purposes of its separation into a number of fractions; a first collection container, for receiving a first fraction of the fluid, in particular a fraction poor in said cells; a second collection container, for receiving a second concentrated fraction of the fluid enriched with said cells; a deviator valve having a first way connected or prearranged for connection to the treatment container, a second way connected or prearranged for connection to the first collection container, and a third way connected or prearranged for connection to the second collection container; a first line for connection of the treatment container to the first way of the deviator valve, a second line for connection of the first collection container to the second way of the deviator valve, and a third line for connection of the second collection container with the third way of the deviator valve.

The treatment container is a syringe container with a plunger having a plunger stem associated in a releasable way to a corresponding plunger head, and the first connection line comprises a first transparent tube, in particular a flexible transparent tube, and at least one of the second and third connection lines preferably comprises a second flexible tube. At least one connection line, or each connection line, further comprises: at least one respective hydraulic connector, for separable connection of a corresponding tube to the corresponding container and/or to the corresponding way of the deviator valve; and at least one automatic-closing or one-way valve.

A system for increasing rates at which fluids may be manually forced through injection/aspiration elements, such as catheters and needles, includes the injection/aspiration elements, as well as a syringe including a pair of crossed handles, one associated with the barrel of the syringe, the other associated with the plunger of the syringe, to provide a mechanical advantage. The system may include and injection/aspiration element of small (e.g., 0.052 inch or smaller) inner diameter and small outer diameter (e.g., 5 French or less). Such systems enable the use of a single hand to hold and operate a syringe in a variety or procedures, including angiography, angioplasty, discography, glue/cement injection, and a variety of aspiration procedures (e.g., biopsy, sampling, media removal, etc.).

An apparatus includes a housing, a flow control mechanism, and an actuator. At least a portion of the flow control mechanism is movably disposed within the housing. The apparatus further includes an inlet port and an outlet port, and defines a fluid reservoir. The outlet port is fluidically coupled to a second fluid reservoir and is fluidically isolated from the first fluid reservoir. The actuator is configured to move the flow control mechanism between a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that the fluid reservoir receives a first flow of bodily-fluid, and a second configuration, in which the inlet port is placed in fluid communication with the outlet port.

Sample processing methods and systems to collect a biological sample. A device may be configured collect a predetermined volume of a sample in sample chamber, and seal the chamber upon activation. The device may be further configured to mix the mix the sample with a predetermined volume of a reagent and/or mix the sample and the reagent in a pre-determined ration.

Disclosed is a centrifugable syringe and syringe components for use in blood fractionation. Also disclosed is a method of blood fractionation using the syringe. The syringe comprises a substantially transparent barrel, a substantially transparent, elongated delineation neck, a plunger for drawing blood into and expelling blood from the barrel, and an adapter attached to the neck for enabling releasable connection of a selected device over an inlet/outlet opening in the neck. The delineation neck extends away from a distal end of the barrel. The barrel and the neck have respective axial bores in fluid flow communication with each other, the cross sectional area of the bore in the delineation neck being substantially less than the cross sectional area of the bore in the barrel. The selected device may be one of various devices including a capping device sealing the inlet/outlet opening of the neck, a needle device used during withdrawal of blood from a subject through the neck, or a hose device used to carry away delineated blood fractions from the syringe through the neck.

A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further postionable by hand manipulation of the housing to contact a volume of liquid to thereby take-up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.

An instrument advancement device includes a housing comprising a fluid path, a distal end, and a proximal end, an instrument disposed within the housing, an advancement element, where in response to movement of the advancement element with respect to the housing, the instrument is configured to advance distal to the distal end of the housing, a small sample dispense device connected to the proximal end of the housing, and a blood collection device connected to a proximal end of the small sample dispense device. The blood collection device is configured to receive an evacuated blood collection container, where the small sample dispense device is detachable from the housing and configured to dispense a blood sample.