The invention relates to a device for detecting at least one substance in the blood of an individual, which comprises a main body and a replaceable sterile head, said replaceable head comprising: means for disinfecting the skin of said individual; means for collecting blood from said individual; means for collecting said blood,
in which the replaceable head comprises means for diluting the blood and in which the replaceable head is functionally connected to the main body of the device

A precision syringe plunger includes a plunger rod and a separately manufactured plunger arm. The plunger rod includes a base formed at a proximal end of the plunger rod and a first interference fit connector formed below the base. The plunger rod is configured to extend longitudinally into a syringe barrel. The plunger arm includes a second interference fit connector formed at a proximal end of the plunger arm. The second interference fit connector is configured to be irreversibly coupled to the first interference fit connector so that the plunger arm extends longitudinally along an outer surface of the syringe barrel. The plunger arm further includes a distally located projection. The projection is configured to receive an applied force that causes an entirety of the syringe plunger to move relative to the syringe barrel so that the plunger rod is actuated through a portion of the syringe barrel.

A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.

The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

A positive pressure hydraulic aspiration syringe is provided. The syringe includes a syringe barrel having a proximal end, a distal end and an inner surface extending there between, a terminal orifice having an inner surface extending from the inner surface of the syringe barrel, a plunger having a proximal end, a distal end, and a sidewall extending there between. The plunger is slidably inserted in the syringe barrel such that the sidewall of the plunger forms a moveable seal against the inner surface of the syringe barrel. The syringe also includes a first piston configured to be displaced as the plunger is slidably inserted in the syringe barrel, a second piston mechanically linked to the first piston. Displacement of the first piston causes displacement of the second piston in an opposite direction of the plunger, which creates a negative pressure vacuum at the terminal orifice.

A syringe assembly includes (i) a syringe with a cylindrical body, luer tip at a first end, finger grip at a second end and a cannula extending from the luer tip into the cylindrical body, and (ii) a plunger unit having an adapter portion, receiving cavity, finger grip and piston. A channel extends the length of the adapter portion to receive the cannula in one end and a variety of connectors, valves and/or syringes in a second end. The end of the channel accessible in the receiving cavity mates with or engages any number of commercially available valves, connectors and/or syringes while the luer tip similarly connects to any number of valves, catheters, connectors, etc., depending on the task being undertaken with the syringe assembly.

A precision syringe includes a syringe barrel and plunger that has a base, an internal portion, and an external portion. The internal portion of the plunger extends longitudinally into the syringe barrel. The internal portion has a first end coupled to the base and a second end that is configured to push fluid out of and/or suction fluid into the syringe barrel. The external portion extends longitudinally along an outer surface of the syringe barrel. The external portion has a first end coupled to the base and a second end that is configured to receive an applied force that causes the plunger to move relative to the syringe barrel so that the second end of the internal portion is actuated through a portion of the syringe barrel (e.g., to dispense fluid from or suction fluid into the syringe barrel).

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

A point-of-care blood collection and dispensing device for use with a luer lock access device, the point-of-care collection and dispensing device including a distal engagement portion, wherein at least a part of the distal engagement portion is configured to engage a needle of the luer lock access device, and a sidewall portion, wherein at least part of the sidewall portion is formed of a flexible material capable of being compressed. The device also includes a fluid chamber configured to hold a blood sample, the fluid chamber bound at least partially by the distal engagement portion and the sidewall portion, as well as an opening, wherein the opening is sized and configured to dispense a small volume of the blood sample held within the fluid chamber when the sidewall portion is compressed.