Brain modelling includes receiving time-coded bio-signal data associated with a user; receiving time-coded stimulus event data; projecting the time-coded bio-signal data into a lower dimensioned feature space; extracting features from the lower dimensioned feature space that correspond to time codes of the time-coded stimulus event data to identify a brain response; generating a training data set for the brain response using the features; training a brain model using the training set, the brain model unique to the user; generating a brain state prediction for the user output from the trained brain model, and automatically computing similarity metrics of the brain model as compared to other user data; and inputting the brain state prediction to a feedback model to determine a feedback stimulus for the user, wherein the feedback model is associated with a target brain state.

Brain modelling includes receiving time-coded bio-signal data associated with a user; receiving time-coded stimulus event data; projecting the time-coded bio-signal data into a lower dimensioned feature space; extracting features from the lower dimensioned feature space that correspond to time codes of the time-coded stimulus event data to identify a brain response; generating a training data set for the brain response using the features; training a brain model using the training set, the brain model unique to the user; generating a brain state prediction for the user output from the trained brain model, and automatically computing similarity metrics of the brain model as compared to other user data; and inputting the brain state prediction to a feedback model to determine a feedback stimulus for the user, wherein the feedback model is associated with a target brain state.

An implantable pulse generator device (110) comprising a processor (117) configured to: receive, in a charging mode, electromagnetic radiation (106) from a charging device (102) wherein the electromagnetic radiation (106) transfers energy to the implantable device (110) to charge an energy storage device (104); measure, in a measurement mode, an electrical field parameter signal representing a neural response; and selectively transition between the charging mode and the measurement mode, such that the implantable device (110) does not receive electromagnetic radiation (106) from the charging device (102) during the measurement of the electrical field parameter signal.

A system includes a communication interface for receiving information that includes data collected from an array of neural activity sensors that were placed on a patient during a session of applied stimuli. A processor is configured to analyze the received information to obtain a frequency spectrum for each sensor for a given stimulus of the applied stimuli. Neural network frequencies that correspond to an indicated impaired functionality of the nervous system of the patient are selected. For each selected frequencies, a spatial map of neural activity is generated. Each of the generated spatial maps is compared with retrieved corresponding spatial maps to identify treatment frequencies from among the selected neural network frequencies. A treatment protocol is generated for input into an electromagnetic field generator to cause the generator to apply to the patient an electromagnetic field at each identified treatment frequency.

A system includes a communication interface for receiving information that includes data collected from an array of neural activity sensors that were placed on a patient during a session of applied stimuli. A processor is configured to analyze the received information to obtain a frequency spectrum for each sensor for a given stimulus of the applied stimuli. Neural network frequencies that correspond to an indicated impaired functionality of the nervous system of the patient are selected. For each selected frequencies, a spatial map of neural activity is generated. Each of the generated spatial maps is compared with retrieved corresponding spatial maps to identify treatment frequencies from among the selected neural network frequencies. A treatment protocol is generated for input into an electromagnetic field generator to cause the generator to apply to the patient an electromagnetic field at each identified treatment frequency.

Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.

Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.

Disclosed is a method for stimulating neural tissue, where the neural tissue includes one or more neurons genetically modified to express a light-sensitive protein. The method comprises applying a light stimulus and an electrical stimulus to the neural tissue, thereby triggering membrane depolarisation in at least one of the neurons. Also disclosed is an apparatus for applying the disclosed method. The apparatus includes a light-stimulation device for selectively applying a light stimulus and an electrical-stimulation device for selectively applying an electrical stimulus to the neural tissue.

A biomagnetic measurement system includes a magnetism measurement apparatus configured to measure a magnetism of a target; and an electrical stimulation apparatus configured to apply a stimulation current to the target. The magnetism measurement apparatus includes a confirming unit configured to confirm a magnitude of an artifact caused by the stimulation current. The electrical stimulation apparatus is configured to output a compensation current for reducing the artifact after the stimulation current is output, based on information from the confirming unit.

System and method to assist two parties to communicate effectively by using an intermediary to project their emotions through a combination of telepathy and empathy, thus synchronizing the adverse parties' emotional states whereby this particular intermediary may be a person capable of natural empathic telepathy.