A force-controlled electroencephalogram (EEG) monitoring device maintains a constant pressure between electrodes and the scalp of a user thereby increasing user comfort. Arms on the EEG monitoring device position the electrodes in contact with specific regions on the head of the user. The dimension, shape, and curvature of the arms affect the amount of force with which an electrode is held in contact with the user's scalp. The amount of pressure may be different for different regions of the user's head to achieve a balance between comfort and conductivity. The amount of pressure may be further modulated by the use of spring-loaded electrode holders that allow an electrode to move relative to the holder. To further improve user comfort, the tips of the electrodes may be hemispherical rather than pointed. The EEG monitoring device can be used as input for a brain-computer interface (BCI).

The present invention relates to systems and methods to manage and predict post-surgical recovery. More specifically, the disclosure generally relates to systems and methods for post-surgical intervention planning, support, follow-up, patient compliance, recovery prediction and tracking, and potential treatment modifications.

The present invention relates to systems and methods to manage and predict post-surgical recovery. More specifically, the disclosure generally relates to systems and methods for post-surgical intervention planning, support, follow-up, patient compliance, recovery prediction and tracking, and potential treatment modifications.

A subcutaneous sensor for use with a continuous glucose monitor includes a reference electrode, a working electrode, and a composition for releasing nitric oxide (NO). The reference electrode includes a reference substrate and an ion limiting layer over the reference substrate. The working electrode includes a conductive substrate, an interference layer over the conductive substrate, an enzyme layer over the interference layer, and a glucose limiting layer. The enzyme layer has an enzyme for reacting with in-vivo glucose in body fluid of a patient. The glucose limiting layer is over the enzyme layer and limits an amount of the in-vivo glucose from the body fluid of the patient that passes to the enzyme layer. The composition for releasing nitric oxide (NO) includes a NO release compound, a hydrophilic material and a hydrophobic material. The composition is on the reference electrode.

A subcutaneous sensor for use with a continuous glucose monitor includes a reference electrode, a working electrode, and a composition for releasing nitric oxide (NO). The reference electrode includes a reference substrate and an ion limiting layer over the reference substrate. The working electrode includes a conductive substrate, an interference layer over the conductive substrate, an enzyme layer over the interference layer, and a glucose limiting layer. The enzyme layer has an enzyme for reacting with in-vivo glucose in body fluid of a patient. The glucose limiting layer is over the enzyme layer and limits an amount of the in-vivo glucose from the body fluid of the patient that passes to the enzyme layer. The composition for releasing nitric oxide (NO) includes a NO release compound, a hydrophilic material and a hydrophobic material. The composition is on the reference electrode.

An electrode includes an electrically non-conductive support. A protruding, electrically conductive attachment element with an attachment site for the releasable attachment of a signal conductor is on an upper face of the support. A conductor is on the underside of the support, and is electrically connected to the attachment element and to a contact medium. The conductor and the contact medium are arranged on the underside of the support. An imaginary normal to the support, running through the attachment element, runs through the conductor or a recess in the conductor and through the contact medium or a recess in the contact medium. The conductor has on its surface a redox pair suitable for the depolarization of the electrode. The attachment element has a projection reaching through the support with a widened region at its end, and the conductor is arranged between the widened region and the support.

An electrode includes an electrically non-conductive support. A protruding, electrically conductive attachment element with an attachment site for the releasable attachment of a signal conductor is on an upper face of the support. A conductor is on the underside of the support, and is electrically connected to the attachment element and to a contact medium. The conductor and the contact medium are arranged on the underside of the support. An imaginary normal to the support, running through the attachment element, runs through the conductor or a recess in the conductor and through the contact medium or a recess in the contact medium. The conductor has on its surface a redox pair suitable for the depolarization of the electrode. The attachment element has a projection reaching through the support with a widened region at its end, and the conductor is arranged between the widened region and the support.

The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.

Systems are provided for an in vivo ketone sensor having a distal portion configured for placement in contact with an interstitial fluid of a user and a proximal portion including a working electrode, a sensing layer with β-hydroxybutyrate dehydrogenase, and a membrane layer configured to limit transport of one or more biomolecules. The in vivo ketone sensor is configured to generate signals at the working electrode corresponding to an amount of ketone in the interstitial fluid. Further, the systems includes a sensor control unit having at least one contact in electrical communication with the proximal portion of the sensor, which is configured to receive the generated signals, and convert the generated signals to ketone concentration data using a sensitivity associated with the in vivo ketone sensor. Also included is a transmitter configured to communicate ketone concentration data to a remote device.

Systems are provided for an in vivo ketone sensor having a distal portion configured for placement in contact with an interstitial fluid of a user and a proximal portion including a working electrode, a sensing layer with β-hydroxybutyrate dehydrogenase, and a membrane layer configured to limit transport of one or more biomolecules. The in vivo ketone sensor is configured to generate signals at the working electrode corresponding to an amount of ketone in the interstitial fluid. Further, the systems includes a sensor control unit having at least one contact in electrical communication with the proximal portion of the sensor, which is configured to receive the generated signals, and convert the generated signals to ketone concentration data using a sensitivity associated with the in vivo ketone sensor. Also included is a transmitter configured to communicate ketone concentration data to a remote device.