A system for performing fluid level measurements on a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, at least some microstructures including an electrode, a signal generator operatively connected to at least one microstructure to apply an electrical stimulatory signal to the at least one microstructure and at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure electrical response signals from at least one microstructure. The system also includes one or more electronic processing devices that determine measured response signals, the response signals being at least partially indicative of a bioimpedance and perform an analysis at least in part using the measured response signals to determine at least one indicator at least partially indicative of fluid levels in the subject.

A system and method for providing a flexible electrocardiogram (ECG) pad structure have been disclosed. In a first aspect, the system is the flexible ECG pad structure and comprises a copper layer and a paste trace layer coupled to the copper layer via a cover. In a second aspect, the method comprises providing a copper layer and coupling a paste trace layer to the copper layer via a cover.

Provided herein are systems, kits, and methods for monitoring brain activity. In some implementations, a system includes a plurality of wearable sensors having a housing with an extended, rounded shape are removably attached to the scalp of a patient and monitor electroencephalogram (EEG) signals. Approaches for instructing a user to position and active that wearable sensors are disclosed. Approaches for facilitating collection, synchronization, and processing of EEG signals are disclosed. Approaches for handing off control of the wearable sensors between portable computing devices are disclosed.

Provided herein are systems, kits, and methods for monitoring brain activity. In some implementations, a system includes a plurality of wearable sensors having a housing with an extended, rounded shape are removably attached to the scalp of a patient and monitor electroencephalogram (EEG) signals. Approaches for instructing a user to position and active that wearable sensors are disclosed. Approaches for facilitating collection, synchronization, and processing of EEG signals are disclosed. Approaches for handing off control of the wearable sensors between portable computing devices are disclosed.

A thermosensitive nanosensor includes a substrate having a plurality of vertically standing nanostructures attached thereto, the plurality of vertically standing nanostructure being covered with a conductive material to form conductive coated nanostructures; a thermosensitive hydrogel adjacent to the plurality of conductive coated nanostructures; and a cover layer on top of the thermosensitive hydrogel to prevent loss of moisture and mechanical stress.

A process for producing an eyelet for a biomedical electrode (e.g. an electrocardiogram (ECG) electrode) involves: hot pressing an electrically conductive thermoplastic or elastomeric resin to produce a film having a web of eyelets, each eyelet having a post protruding from a first face of the film and a flange at a second face of the film; applying a coating of a non-polarizable conductive material (e.g. a silver-containing material) on to a contact face of the flange; and, cutting the film to produce the eyelets separated from the web. Preferably, the process involves extrusion replication. A web of eyelets for biomedical electrodes has a film of an electrically conductive thermoplastic or elastomeric resin possessing a plurality of posts protruding from a first face of the film, and preferably a layer of a non-polarizable conductive material on a second face of the film. The process may be a one-step continuous process that is cheaper and simpler than current commercial processes.

This disclosure provides an electrode body in which an electrode is firmly fixed to a gel without performing electrolytic polymerization. In the electrode body, at a least part of a surface of an electrode is uneven, at least a part of the uneven surface of the electrode is covered with a gel, the gel has a three-dimensional network structure, at least a part of the uneven surface is in contact with the three-dimensional network structure and is embedded inside the three-dimensional network structure. The electrode is preferably a laminated body in which a resin layer is laminated on both surfaces of a conductive base material. It is more preferably that the conductive base material be a fabric woven from fibers and the uneven surface be a surface of the fabric.

A system for continuously humidifying a textile electrode during its use by a human is disclosed. The electrode can be part of a garment or textile where the textile electrode is positioned against the skin. A reservoir positioned against the electrode and opposite the user's skin can be made from a material with hydrophilic and hydrophobic properties, such as natural wool or a skincore material. The reservoir receives and retains moisture from the user's skin through the electrode, as well as from a pre-wetting of the exposed user-facing side of the electrode. A seal can surround the reservoir and the electrode, with the seal extending beyond electrode. The seal can be a patch with heat activated adhesive at the edge to flow the textile to form a moisture barrier around the electrode. An electrical contact on the electrode can connect conductive wires from outside the seal to the electrode.

A textile made from a single knitted layer having an inert region and a conductive trace region is disclosed. The inert region is knitted using an electrically inert or non-externally conductive yarn and the conductive trace region is knitted from a hybrid yarn containing a non-conductive yarn twisted with a conductive wire, with the conductive wire having an exterior insulating layer. The conductive trace can transmit an electrical data or power signal along the textile via the conductive wire. The insulating layer of the wire can be removed in the conductive trace region to expose the conductive exterior of the wire to enable electrical connections to the conductive trace region. The textile can include a textile electrode knitted from an externally conductive yarn and the conductive trace region can be electrically connected to the electrode to transmit an electrical signal to or from the textile electrode.

A process for producing a sensor for a biomedical electrode (e.g. an ECG electrode) involves injection molding an electrically conductive resin through a film of a backing material to form the sensor directly in the backing material and coating the contact face of the sensor with a non-polarizable conductive material (e.g. silver-containing material). Additional steps of applying an electrolyte over the non-polarizable conductive material coated on the contact face and applying a liner over the electrolyte results in the biomedical electrode. Biomedical electrode produced thereby have the sensor secured in a film of the backing material with a contact face of the sensor disposed on a first side of the film and a post of the sensor protruding from a second side of the film opposite the first side. The process permits production of one-piece sensors for bioelectrodes in a continuous fashion without the need for studs to retain sensors in a film of the backing material.