An electrophysiology catheter includes: a catheter with a movable catheter tip; electrodes provided on or in an electrode region in a most distal portion of the catheter tip; sensing and amplification circuitry communicated with the electrodes, the sensing and amplification circuitry communicated with digitizing circuitry disposed in a circuitry region in a least distal portion of the catheter tip for locally sensing tissue-based electrophysiological signals and for bidirectionally communicating digital data signals to and from the circuitry; a flexible bending region of the catheter tip between the most and least distal portions of the catheter tip; a flexible sheath communicated to the sensing and amplification circuitry and digitizing circuitry for transmission of signals thereon; and a handle communicated with the sheath for bidirectionally communicating signals through the sheath between the catheter tip and external mapping station, and for controlling movement of the catheter tip.

An electrophysiology catheter includes: a catheter with a movable catheter tip; electrodes provided on or in an electrode region in a most distal portion of the catheter tip; sensing and amplification circuitry communicated with the electrodes, the sensing and amplification circuitry communicated with digitizing circuitry disposed in a circuitry region in a least distal portion of the catheter tip for locally sensing tissue-based electrophysiological signals and for bidirectionally communicating digital data signals to and from the circuitry; a flexible bending region of the catheter tip between the most and least distal portions of the catheter tip; a flexible sheath communicated to the sensing and amplification circuitry and digitizing circuitry for transmission of signals thereon; and a handle communicated with the sheath for bidirectionally communicating signals through the sheath between the catheter tip and external mapping station, and for controlling movement of the catheter tip.

The present invention is directed to an electrode system for recording nerve action potential (NAP) from surgically exposed nerve and methods for using such an electrode system. Electrophysiological methods are used during repair surgery of peripheral nerve trauma (PNT). PNT is a major medical problem with an annual incidence similar to that of epilepsy. Surgical intervention is provided based on the severity of nerve injury which is determined preoperatively and intraoperatively mainly by electrophysiological assessments. Among those, intraoperative nerve action potential (NAP) or compound action potential (CNAP) recording is preferred for direct assessment of functional continuity of the nerve.

The present invention is directed to an electrode system for recording nerve action potential (NAP) from surgically exposed nerve and methods for using such an electrode system. Electrophysiological methods are used during repair surgery of peripheral nerve trauma (PNT). PNT is a major medical problem with an annual incidence similar to that of epilepsy. Surgical intervention is provided based on the severity of nerve injury which is determined preoperatively and intraoperatively mainly by electrophysiological assessments. Among those, intraoperative nerve action potential (NAP) or compound action potential (CNAP) recording is preferred for direct assessment of functional continuity of the nerve.

A method may include obtaining first and second time series (TS1), (TS2) of stimulation data, and a first and second time series of control data. TS1, TS2 may provide a plurality of pairs of data points such that each of the plurality of pairs include corresponding data points from both TS1 and TS2. The obtained time series may be analyzed by applying an algorithm (Alg) to TS1 and TS2 of stimulation data to create an algorithm value corresponding to each of the plurality of pairs of data points. Alg=(|TS1|+|TS2|)/2−|TS1−TS2|. Positive algorithm values for a predetermined period of time (AlgVarTime) may be summed to create a signal. Peak(s) in the signal may be determined, and a conduction velocity may be determined using a latency and a distance between a stimulus electrode and a recording electrode.

A method may include obtaining first and second time series (TS1), (TS2) of stimulation data, and a first and second time series of control data. TS1, TS2 may provide a plurality of pairs of data points such that each of the plurality of pairs include corresponding data points from both TS1 and TS2. The obtained time series may be analyzed by applying an algorithm (Alg) to TS1 and TS2 of stimulation data to create an algorithm value corresponding to each of the plurality of pairs of data points. Alg=(|TS1|+|TS2|)/2−|TS1−TS2|. Positive algorithm values for a predetermined period of time (AlgVarTime) may be summed to create a signal. Peak(s) in the signal may be determined, and a conduction velocity may be determined using a latency and a distance between a stimulus electrode and a recording electrode.

Disclosed herein are a neural signal feedback system and method. The neural signal feedback system includes: a microelectrode array unit configured such that a plurality of microelectrodes is disposed on a substrate and such that one microelectrode, which is a reference electrode, and corresponding electrode groups including other microelectrodes located at different same distances from the reference electrode are set; and an analysis and determination unit configured to compare neural signal values, measured in the microelectrode array unit, with a preset reference value, and to determine whether to apply the electrical stimulation of the microelectrode array unit. The analysis and determination unit performs re-measurement after the application of electrical stimulation, and repeats the application of electrical stimulation and measurement until the measured values reach the reference value.

Disclosed herein are a neural signal feedback system and method. The neural signal feedback system includes: a microelectrode array unit configured such that a plurality of microelectrodes is disposed on a substrate and such that one microelectrode, which is a reference electrode, and corresponding electrode groups including other microelectrodes located at different same distances from the reference electrode are set; and an analysis and determination unit configured to compare neural signal values, measured in the microelectrode array unit, with a preset reference value, and to determine whether to apply the electrical stimulation of the microelectrode array unit. The analysis and determination unit performs re-measurement after the application of electrical stimulation, and repeats the application of electrical stimulation and measurement until the measured values reach the reference value.

An electrode device for recording electrophysiological neurosignals in nervous tissue of a living being includes a bundle of insulated electrical cables, where each cable has an electrical wire made of electrically conductive material and an insulation layer which covers and insulates the electrical wire. An electrical connector connects the electrical wires to a recording device. A free end of the bundle of insulated electrical cables distant from the electrical connector includes an implantation section for implantation in the nervous tissue of the living being. An electrophysiological recording system will have at least one such electrode device and a computer program arranged for execution on a computer.

An electrode device for recording electrophysiological neurosignals in nervous tissue of a living being includes a bundle of insulated electrical cables, where each cable has an electrical wire made of electrically conductive material and an insulation layer which covers and insulates the electrical wire. An electrical connector connects the electrical wires to a recording device. A free end of the bundle of insulated electrical cables distant from the electrical connector includes an implantation section for implantation in the nervous tissue of the living being. An electrophysiological recording system will have at least one such electrode device and a computer program arranged for execution on a computer.