Disclosed is a method and system for selecting a reference electrode wherein at least one electrode of an electrode assembly is configured in a sensing mode and is connected to a sensing circuitry configured to measure a neural potential. Further, the electrodes configured in the sensing mode includes at least one measuring electrode and at least one reference electrode. The method and system can configure the electrodes of the electrode assembly based on conditions related to the stimulation and neural measurement.

Disclosed is a method and system for selecting a reference electrode wherein at least one electrode of an electrode assembly is configured in a sensing mode and is connected to a sensing circuitry configured to measure a neural potential. Further, the electrodes configured in the sensing mode includes at least one measuring electrode and at least one reference electrode. The method and system can configure the electrodes of the electrode assembly based on conditions related to the stimulation and neural measurement.

An implantable device is configured to control application of a neural stimulus as defined by a stimulus parameter; measure via the measurement circuitry a characteristic of a neural compound action potential response evoked by the stimulus; and compute, using the stimulus parameter and the measured characteristic of the evoked neural compound action potential response, a characteristic of an evoked response that would be obtained from the neural stimulus if the patient were in a reference posture. A posture of the patient can be estimated from the computed characteristic and/or the computed characteristic can be used as a feedback variable of a feedback loop. Multidimensional histograms of datasets comprising at least one of the stimulus parameter and a feedback variable can be stored.

An implantable device is configured to control application of a neural stimulus as defined by a stimulus parameter; measure via the measurement circuitry a characteristic of a neural compound action potential response evoked by the stimulus; and compute, using the stimulus parameter and the measured characteristic of the evoked neural compound action potential response, a characteristic of an evoked response that would be obtained from the neural stimulus if the patient were in a reference posture. A posture of the patient can be estimated from the computed characteristic and/or the computed characteristic can be used as a feedback variable of a feedback loop. Multidimensional histograms of datasets comprising at least one of the stimulus parameter and a feedback variable can be stored.

Systems and methods for gesture control are described. In some embodiments, a system for assessing a physiological state of a user. The system may include the wearable device comprising one or more electrodes configured to be disposed adjacent to an external surface of the skin portion. A first timestamp may be determined. The first timestamp may indicate a first time at which a stimulus is presented to the user. A second timestamp indicating a second time at which the biopotential signals indicate an intention by the user to perform a responsive action may be determined. Based at least on the first timestamp and the second timestamp, determine a subject response time for the user. The subject response time may be compared to a baseline response time for the user to generate an assessment of a physiological state of the user.

Systems and methods for gesture control are described. In some embodiments, a system for assessing a physiological state of a user. The system may include the wearable device comprising one or more electrodes configured to be disposed adjacent to an external surface of the skin portion. A first timestamp may be determined. The first timestamp may indicate a first time at which a stimulus is presented to the user. A second timestamp indicating a second time at which the biopotential signals indicate an intention by the user to perform a responsive action may be determined. Based at least on the first timestamp and the second timestamp, determine a subject response time for the user. The subject response time may be compared to a baseline response time for the user to generate an assessment of a physiological state of the user.

The present disclosure provides a peripheral nerve signal acquisition method and system. The method includes: wearing a wearable device on a human wrist, disposing a perturbation unit in the wearable device, and applying mechanical perturbations perpendicular to a neural pathway to a skin surface during electrical stimulation cycles; under the action of the mechanical perturbations, acquiring a first signal, a second signal, and a third signal; performing multi-channel time-delay encoding on the first signal and the second signal to generate an interference signal set with temporal phase differences; constructing an artifact template signal associated with the electrical stimulation based on the third signal; performing artifact cancellation processing on the first signal and the second signal; and performing spatial analytical analysis in combination with a peripheral nerve pathway map, identifying an initiation site and a conduction pathway of peripheral nerve discharges, and outputting authentic discharge signals of the peripheral nerves.

The present disclosure provides a peripheral nerve signal acquisition method and system. The method includes: wearing a wearable device on a human wrist, disposing a perturbation unit in the wearable device, and applying mechanical perturbations perpendicular to a neural pathway to a skin surface during electrical stimulation cycles; under the action of the mechanical perturbations, acquiring a first signal, a second signal, and a third signal; performing multi-channel time-delay encoding on the first signal and the second signal to generate an interference signal set with temporal phase differences; constructing an artifact template signal associated with the electrical stimulation based on the third signal; performing artifact cancellation processing on the first signal and the second signal; and performing spatial analytical analysis in combination with a peripheral nerve pathway map, identifying an initiation site and a conduction pathway of peripheral nerve discharges, and outputting authentic discharge signals of the peripheral nerves.

A system for recording, processing, and monitoring biosignals is provided, the system being configured to suspend data acquisition whenever an electric surgical tool or other generator of high frequency interference is in use. Such a system may protect the hardware of the system and reduce or eliminate the acquisition of distorted signals. The system of some embodiments includes an amplifier system configured to detect the presence of high frequency interference. Related methods are also disclosed.

A system for recording, processing, and monitoring biosignals is provided, the system being configured to suspend data acquisition whenever an electric surgical tool or other generator of high frequency interference is in use. Such a system may protect the hardware of the system and reduce or eliminate the acquisition of distorted signals. The system of some embodiments includes an amplifier system configured to detect the presence of high frequency interference. Related methods are also disclosed.