In one embodiment the invention provides a process of capturing a biopotential signal at a surface of a body using a sensor receiver which forms a first signal connection the body wherein one or more parameters of impedance of the first signal connection are unknown. The process comprises receiving the biopotential signal at an output of a first signal channel having a first transfer function which is dependent on the one of more unknown first impedance parameters. The process also comprises receiving the biopotential signal at an output of a second signal channel having a second transfer function dependent on the one of more unknown first impedance parameters. The process also comprises deriving a set of relations for the biopotential signal. The set of relations is defined dependent on the transfer function of the first signal channel, the transfer function of the second signal channel, and outputs of the first and second signal channels; and solving the set of relations to determine the captured biopotential signal.

A method of displaying a virtual electrogram for a virtual bipole includes receiving a plurality of electrophysiological signals from a respective plurality of electrodes carried by a multi-dimensional catheter; using the received electrophysiological signals to compute a plurality of virtual electrograms associated with a respective plurality of virtual bipoles, each having a corresponding virtual bipole orientation; selecting a virtual bipole orientation; and displaying the virtual electrogram associated with the virtual bipole having the selected virtual bipole orientation. Aspects of the disclosure can be executed through a graphical user interface of an electroanatomical mapping system that also incorporates a visualization processor.

A method of displaying a virtual electrogram for a virtual bipole includes receiving a plurality of electrophysiological signals from a respective plurality of electrodes carried by a multi-dimensional catheter; using the received electrophysiological signals to compute a plurality of virtual electrograms associated with a respective plurality of virtual bipoles, each having a corresponding virtual bipole orientation; selecting a virtual bipole orientation; and displaying the virtual electrogram associated with the virtual bipole having the selected virtual bipole orientation. Aspects of the disclosure can be executed through a graphical user interface of an electroanatomical mapping system that also incorporates a visualization processor.

A system includes signal acquisition circuitry and a processor. The signal acquisition circuitry is configured to receive multiple intra-cardiac signals acquired by multiple electrodes of an intra-cardiac probe in a heart of a patient. The processor is configured to perform a sequence of annotation-visualization operations at subsequent times, by performing, in each operation: extracting multiple annotation values from the intra-cardiac signals, selecting a group of the intra-cardiac signals, identifying in the group one or more annotation values that are statistically deviant by more than a predefined measure of deviation, and visualizing the annotation values to a user, while omitting and refraining from visualizing the statistically deviant annotation values. The processor is further configured to assess, over one or more of the annotation-visualization operations, a rate of omissions of annotation values, and to take a corrective action in response to detecting that the rate of omissions exceeds a predefined threshold.

A system includes signal acquisition circuitry and a processor. The signal acquisition circuitry is configured to receive multiple intra-cardiac signals acquired by multiple electrodes of an intra-cardiac probe in a heart of a patient. The processor is configured to perform a sequence of annotation-visualization operations at subsequent times, by performing, in each operation: extracting multiple annotation values from the intra-cardiac signals, selecting a group of the intra-cardiac signals, identifying in the group one or more annotation values that are statistically deviant by more than a predefined measure of deviation, and visualizing the annotation values to a user, while omitting and refraining from visualizing the statistically deviant annotation values. The processor is further configured to assess, over one or more of the annotation-visualization operations, a rate of omissions of annotation values, and to take a corrective action in response to detecting that the rate of omissions exceeds a predefined threshold.

Systems, methods, apparatuses, and computer program for reconstructing electrocardiogram (ECG) waveforms from photoplethysmogram (PPG). A method for cardiovascular monitoring and analytics may include obtaining an electrical signal of a heart. The method may also include obtaining a circulatory signal related to a pulsatile volume of blood in tissue. The method may also include preprocessing the electrical signal and the circulatory signal. The method may further include training a mapping using the preprocessed electrical signal and circulatory signal. In addition, the method may include deriving cardiovascular data based on the trained mapping of the preprocessed electrical signal or circulatory signal.

A cardiac device is provided including a measuring electrode, a signal-processing unit and a post-processing unit. The measuring electrode is adapted to be positioned within the blood pool of a human or an animal heart, in order to measure a depolarization-signal. The signal-processing unit is connected to the measuring electrode and is adapted to remove signal components with frequencies lower than a cut-off frequency from the measured depolarization-signal. The post-processing unit is connected to the signal-processing unit and is adapted to determine, based on the Brody effect, a measure for a ventricular volume of the heart based on the modified depolarization-signal. Furthermore, a method for the determination of a measure for a ventricular volume of a heart and a computer program product for performing the steps of this method are provided.

Systems and methods are described herein related to the evaluation and adjustment of left bundle branch (LBB) pacing therapy. Evaluation of the LBB pacing therapy may utilize electrical activity monitored from a plurality of external electrodes. The electrical activity may be used to provided one or more metrics of dispersion of surrogate cardiac electrical activation times, which may then be used to evaluate, and potentially adjust the LBB pacing therapy.

Described herein are devices, systems, and methods for sensing and generating a one or more of the 12 leads of a standard ECG with a mobile computing device. In some embodiments, three electrodes are positioned on a mobile computing device so that an individual may comfortably contact all three sensors at once to generate a six lead ECG which may be displayed on a display of said mobile computing device. In some embodiments, analysis carried out further comprises determining a QRS axis and QRST angle.

Described herein are devices, systems, and methods for sensing and generating a one or more of the 12 leads of a standard ECG with a mobile computing device. In some embodiments, three electrodes are positioned on a mobile computing device so that an individual may comfortably contact all three sensors at once to generate a six lead ECG which may be displayed on a display of said mobile computing device. In some embodiments, analysis carried out further comprises determining a QRS axis and QRST angle.