A wearable monitoring device comprising a printed circuit board having a first side and a second side opposite the first side, wherein the printed circuit board is configured to couple to at least one sensor configured to monitor a physiological condition; a first padding layer coupled to the printed circuit board proximate the first side; a second padding layer coupled to the printed circuit board proximate the second side; a first protective layer coupled to the first padding layer opposite the printed circuit board; a second protective layer coupled to the second padding layer opposite the printed circuit board, the first protective layer and the second protective layer seal together and enclose the first and second padding and the printed circuit board; a power source coupled to the printed circuit board.

Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.

If a job is accepted in the middle of cardiac potential measurement in a state where acquisition of data for stress measurement corresponding to cycles necessary for stress measurement has not been completed, the state of progress of stress measurement is compared with the acceptance timing of the job, and with respect to acceptance of a job for which a time from the acceptance timing of the job to completion of stress measurement on a current measurement object cycle does not exceed a pre-set first setting value, the job is executed after completion of stress measurement in the current measurement cycle, and with respect to acceptance of a job for which a time from the acceptance timing of the job to completion of stress measurement exceeds the first setting value, stress measurement is interrupted and the job is preferentially executed and stress measurement is restarted.

A system of providing a preferred fitness state of a user, the system comprising a computing device, wherein the computing device is configured to receive, at least a first biological parameter; determine, a current user fitness state, wherein determining the current user fitness state further comprises generating the current user fitness state using a fitness state model relating biological parameters to fitness states and a first machine-learning algorithm; and identify, a user specific recommendation as a function of the at least a first biological parameter and the current user fitness state.

An ambulatory medical device configured to assess a patient's physical condition is provided. The device includes externally worn ECG sensing electrodes configured to detect at least one cardiac electric signal of the patient, motion detectors configured to detect at least one motion signal indicative of patient movement, and a processor operably coupled to the sensing electrodes and the motion detectors. The processor is configured to receive, for the patient, initiating criterion corresponding to an ambulatory exertion test, wherein the initiating criterion specifies heartrate-dependent parameter requirements and/or activity level-dependent parameter requirements; continuously monitor a current heartrate-dependent parameter and/or a current activity level-dependent parameter of the patient; periodically determine whether the current heartrate-dependent parameter and/or the current activity level-dependent parameter satisfies the initiating criterion; invite the patient to participate in the ambulatory exertion test; and initiate, upon receiving patient input indicating acceptance of the invitation, the ambulatory exertion test.

An ambulatory medical device configured to assess a patient's physical condition is provided. The device includes externally worn ECG sensing electrodes configured to detect at least one cardiac electric signal of the patient, motion detectors configured to detect at least one motion signal indicative of patient movement, and a processor operably coupled to the sensing electrodes and the motion detectors. The processor is configured to receive, for the patient, initiating criterion corresponding to an ambulatory exertion test, wherein the initiating criterion specifies heartrate-dependent parameter requirements and/or activity level-dependent parameter requirements; continuously monitor a current heartrate-dependent parameter and/or a current activity level-dependent parameter of the patient; periodically determine whether the current heartrate-dependent parameter and/or the current activity level-dependent parameter satisfies the initiating criterion; invite the patient to participate in the ambulatory exertion test; and initiate, upon receiving patient input indicating acceptance of the invitation, the ambulatory exertion test.

A biological information measurement device, including an electrode contact state detector including a first contact detection circuit connected to either the first electrode or the second electrode among the electrodes, a second contact detection circuit connected to the third electrode, and a contact state determinator for determining a contact state indicating which of the electrodes is in contact with a surface of the measurement target based on a first signal output from the first contact detection circuit and a second signal output from the second contact detection circuit, and an input receiver for receiving a contact of the electrode with respect to the surface of the measurement target as input of predetermined operation associated with the contact state.

A biological information measurement device, including an electrode contact state detector including a first contact detection circuit connected to either the first electrode or the second electrode among the electrodes, a second contact detection circuit connected to the third electrode, and a contact state determinator for determining a contact state indicating which of the electrodes is in contact with a surface of the measurement target based on a first signal output from the first contact detection circuit and a second signal output from the second contact detection circuit, and an input receiver for receiving a contact of the electrode with respect to the surface of the measurement target as input of predetermined operation associated with the contact state.

Systems and methods for monitoring patients with multiple chronic diseases are described. A system may include a health status monitor that receives diagnostic data including physiological signals sensed from a patient. The system may produce at least a first risk indication of the patient developing a first disease and a second risk indication of the patient developing a different second disease. The system may detect the first and second diseases from the physiological signals, and generate a composite health status indicator using the detections of the first and second diseases and the first and second risk indications. An alert of worsening health status may be generated if the composite detection score exceeds an alert threshold.

Provided is an exercise electrocardiogram data analysis method, which includes: acquiring and analyzing exercise electrocardiogram data to obtain a high-frequency QRS waveform curve; selecting a first reference point and a second reference point from the high-frequency QRS waveform curve; according to the first reference point, the second reference point and the high-frequency QRS waveform curve, determining the area of a waveform descent area; and according to the area of the waveform descent area, determining the attention level.