A medical analysis system, includes at least one catheter to be inserted into a body-part having a tissue surface, and comprising sensing electrodes to contact and receive electrical signals from the tissue surface, and processing circuitry to receive unipolar signals from individual ones of the plurality of the sensing electrodes, compute a combined far-field and mid-field signal based on summing and filtering ones of the received unipolar signals received from at least a pair of sensing electrodes disposed around a point of interest, compute a far-field signal as a weighted average of the received unipolar signals, weighted according to respective distances of the sensing electrodes from the point of interest, and compute and output a mid-field signal, representative of electrical activity below the tissue surface at the point of interest, based on subtracting the computed far-field signal from the computed combined far-field and mid-field signal.

A medical analysis system, includes at least one catheter to be inserted into a body-part having a tissue surface, and comprising sensing electrodes to contact and receive electrical signals from the tissue surface, and processing circuitry to receive unipolar signals from individual ones of the plurality of the sensing electrodes, compute a combined far-field and mid-field signal based on summing and filtering ones of the received unipolar signals received from at least a pair of sensing electrodes disposed around a point of interest, compute a far-field signal as a weighted average of the received unipolar signals, weighted according to respective distances of the sensing electrodes from the point of interest, and compute and output a mid-field signal, representative of electrical activity below the tissue surface at the point of interest, based on subtracting the computed far-field signal from the computed combined far-field and mid-field signal.

Improvements to intracardiac devices such as intracardiac blood pump assemblies, and associated methods. In one example, the present technology includes systems and methods for pacing the heart, and/or performing cardiac ablation using electrodes mounted on a portion of the intracardiac device. In another example, the present technology includes systems and methods for detecting mural thrombi in a patient's heart using electrical sensors or ultrasonic phased arrays mounted on the intracardiac device. In another example, the present technology includes systems and methods for detecting tissue changes and reactions in heart tissue during treatment using one or more temperature sensors. In another example, the present technology includes an improved distal tip for use with an intracardiac device. In another example, the present technology includes systems and methods for maintaining an intracardiac device in a desired position within a patient's heart using magnets or ultrasonic phased arrays mounted on the intracardiac device.

Improvements to intracardiac devices such as intracardiac blood pump assemblies, and associated methods. In one example, the present technology includes systems and methods for pacing the heart, and/or performing cardiac ablation using electrodes mounted on a portion of the intracardiac device. In another example, the present technology includes systems and methods for detecting mural thrombi in a patient's heart using electrical sensors or ultrasonic phased arrays mounted on the intracardiac device. In another example, the present technology includes systems and methods for detecting tissue changes and reactions in heart tissue during treatment using one or more temperature sensors. In another example, the present technology includes an improved distal tip for use with an intracardiac device. In another example, the present technology includes systems and methods for maintaining an intracardiac device in a desired position within a patient's heart using magnets or ultrasonic phased arrays mounted on the intracardiac device.

A connector may include a first housing configured to detachably secure a first input cable of a first sensor configured to generate a first signal, and a second housing configured to detachably secure a second input cable of a second sensor configured to generate a second signal. The second housing may be configured to transmit the second signal from the second input cable to the first housing. The first housing may be configured to transmit at least one of the first signal and the second signal to an output cable. A coupling of the first housing may be configured to mate with a coupling of the second housing such that the first housing and the second housing are configured to be detachably secured to each other. The coupling may be mechanical, electro-mechanical, or magnetic. Either sensor may be an electrocardiogram sensor or a pulse oximetry sensor.

A connector may include a first housing configured to detachably secure a first input cable of a first sensor configured to generate a first signal, and a second housing configured to detachably secure a second input cable of a second sensor configured to generate a second signal. The second housing may be configured to transmit the second signal from the second input cable to the first housing. The first housing may be configured to transmit at least one of the first signal and the second signal to an output cable. A coupling of the first housing may be configured to mate with a coupling of the second housing such that the first housing and the second housing are configured to be detachably secured to each other. The coupling may be mechanical, electro-mechanical, or magnetic. Either sensor may be an electrocardiogram sensor or a pulse oximetry sensor.

A neurostimulation system comprises a control system configured to monitor a patient receiving neurostimulation therapy. The neurostimulation therapy has a stimulation cycle comprising a stimulation ON period, in which the patient is receiving neurostimulation, and a stimulation OFF period, in which the patient is not receiving neurostimulation. The control system is programmed to receive electrocardiogram (ECG) data from the patient receiving the neurostimulation therapy. The control system is further programmed to monitor a heart rate of the patient based on the ECG data over at least one stimulation cycle of the neurostimulation therapy. The control system is further programmed to generate an indication of signal stability to be displayed to a user based on the received ECG data.

Implantable medical device configured to detect an atrial electric signal of a heart, and a ventricular electric signal of the same heart. Atrial events are evaluated in the atrial electric signal detected by a first detection unit and/or ventricular events are evaluated in the ventricular electric signal detected by a second detection unit for recognizing a condition of the device in which atrial electric signals are insufficiently detected.

Evaluation is done by applying at least one of: morphology of the detected atrial electric signals; lacking stability of atrial events; absence of atrial events over a period of time; an amplitude of the detected atrial electric signal being lower than a predefined threshold value; absence of atrial events during detection of ventricular electric signals simultaneously; comparison of atrial events sensed with first and second sensing profiles, the second being more sensitive than the first.

Implantable medical device configured to detect an atrial electric signal of a heart, and a ventricular electric signal of the same heart. Atrial events are evaluated in the atrial electric signal detected by a first detection unit and/or ventricular events are evaluated in the ventricular electric signal detected by a second detection unit for recognizing a condition of the device in which atrial electric signals are insufficiently detected.

Evaluation is done by applying at least one of: morphology of the detected atrial electric signals; lacking stability of atrial events; absence of atrial events over a period of time; an amplitude of the detected atrial electric signal being lower than a predefined threshold value; absence of atrial events during detection of ventricular electric signals simultaneously; comparison of atrial events sensed with first and second sensing profiles, the second being more sensitive than the first.

A system and method for designating between types of activation by a pulse generator configured to deliver a left ventricular (LV) pacing pulse at an LV pacing site as part of a cardiac resynchronization therapy (CRT) are provided. The system includes a sensing channel configured to collect cardiac activity (CA) signals along at least one sensing vector extending through a septal wall between the LV and right ventricle (RV). The CA signals are indicative of one or more beats and include a pre-LV pacing segment indicative of cardiac activity preceding the LV pacing pulse and a post-LV pacing segment indicative of cardiac activity following the LV pacing pulse. The system includes memory to store program instructions. One or more processors are configured to implement the program instructions to analyze the pre-LV pacing segment to identify a first myocardium activation (MA) characteristic of interest (COI). The system analyzes the post-LV pacing segment to a second MA COI, compares the first and second MA COI to first and second MA criteria, respectively, designates the CA signals to be indicative of one of a fusion beat, a capture beat or a pseudofusion beat based on the comparison of the first and second MA COI to first and second MA criteria and store a result of the designation.