Disclosed are various examples and embodiments of systems, devices, components and methods configured to estimate the action potential wave propagation in a patient's heart, and subsequently to detect at least one location or type of at least one source of, or rotational phenomenon associated with, at least one cardiac rhythm disorder using intracardiac electrodes and a modified multi-frame Horn-Schunck algorithm to generate a map corresponding to a spatial map, the map being configured to reveal on a monitor or display to a user the at least one location of the at least one source of the at least one cardiac rhythm disorder.

There is provided a computerized method of tracking a position of an intra-body catheter, comprising: physically tracking coordinates of the position of a distal portion of a physical catheter within the physical body portion of the patient according to physically applied plurality of electrical fields within the body portion and measurements of the plurality of electrical fields performed by a plurality of physical electrodes at a distal portion of the physical catheter; registering the physically tracked coordinates with simulated coordinates generated according to a simulation of a simulated catheter within a simulation of the body of the patient, to identify differences between physically tracked location coordinates and the simulation coordinates; correcting the physically tracked location coordinates according to the registered simulation coordinates; and providing the corrected physically tracked location coordinates for presentation.

There is provided a computerized method of tracking a position of an intra-body catheter, comprising: physically tracking coordinates of the position of a distal portion of a physical catheter within the physical body portion of the patient according to physically applied plurality of electrical fields within the body portion and measurements of the plurality of electrical fields performed by a plurality of physical electrodes at a distal portion of the physical catheter; registering the physically tracked coordinates with simulated coordinates generated according to a simulation of a simulated catheter within a simulation of the body of the patient, to identify differences between physically tracked location coordinates and the simulation coordinates; correcting the physically tracked location coordinates according to the registered simulation coordinates; and providing the corrected physically tracked location coordinates for presentation.

This specification describes methods of performing ECG analyses. In one approach, the system receives an ECG recording for a first duration, automatically performs a first analysis of the ECG recording for the first duration to detect events with reference to each of a plurality of arrhythmias, generates a GUI where areas within the GUI are designated for displaying detected events for each of the arrhythmias and enables a user to select at least one ECG segment of a second duration of the ECG recording. In response to the user's selection of the at least one ECG segment, the system presents the user with at least one option, and in response to the user's selection of the option, the system performs a second analysis of the ECG segment of the second duration and displays at least one output corresponding to the second analysis.

This specification describes methods of performing ECG analyses. In one approach, the system receives an ECG recording for a first duration, automatically performs a first analysis of the ECG recording for the first duration to detect events with reference to each of a plurality of arrhythmias, generates a GUI where areas within the GUI are designated for displaying detected events for each of the arrhythmias and enables a user to select at least one ECG segment of a second duration of the ECG recording. In response to the user's selection of the at least one ECG segment, the system presents the user with at least one option, and in response to the user's selection of the option, the system performs a second analysis of the ECG segment of the second duration and displays at least one output corresponding to the second analysis.

In one embodiment, a medical system includes a catheter configured to be inserted into a heart of a living subject, and including electrodes configured to capture electrical activity of the heart at respective position in the heart, a display, and processing circuitry configured to receive position signals from the catheter, and in response to the position signals compute the respective positions of the electrodes, generate an anatomical map responsively to respective ones of the computed positions, find an anatomical feature of the heart and a position of the anatomical feature responsively to the respective positions of, and electrical activity captured by, respective ones of the electrodes, automatically segment the anatomical map responsively to the found position of the anatomical feature, and render the anatomical map to the display.

In some embodiments, there are provided systems, devices, components, and corresponding methods configured to permit navigation and or positioning of an intra-cardiac electrophysiological (EP) mapping basket of an EP mapping catheter inside or near an atrium or other heart chamber of a patient's heart using biosignals or intra-cardiac signals. In one embodiment, QRS complexes are extracted or isolated from intra-cardiac signals sensed by electrodes mounted on the EP mapping basket. Using the QRS complexes, one or more computing devices then determine the locations of the electrodes inside or near the patient's atrium that are associated with each isolated or extracted QRS complex. The one or more computing devices can also be used to determine changes in the three-dimensional locations and orientations of the basket and the electrodes thereof as the basket is moved around, in, or near the patient's atrium, heart chamber, or other portion of the patient's heart. The computing device can also be configured to use position change detection methods to detect basket catheter movements inside or near the patient's heart, determine the three-dimensional coordinates X of each electrode for a given position and orientation of the basket within the patient's heart, determine and display to a user multiple positions of the basket inside or near the patient's heart, and provide a visual display to a user of the locations of the electrodes and/or basket inside or near the patient's heart.

In some embodiments, there are provided systems, devices, components, and corresponding methods configured to permit navigation and or positioning of an intra-cardiac electrophysiological (EP) mapping basket of an EP mapping catheter inside or near an atrium or other heart chamber of a patient's heart using biosignals or intra-cardiac signals. In one embodiment, QRS complexes are extracted or isolated from intra-cardiac signals sensed by electrodes mounted on the EP mapping basket. Using the QRS complexes, one or more computing devices then determine the locations of the electrodes inside or near the patient's atrium that are associated with each isolated or extracted QRS complex. The one or more computing devices can also be used to determine changes in the three-dimensional locations and orientations of the basket and the electrodes thereof as the basket is moved around, in, or near the patient's atrium, heart chamber, or other portion of the patient's heart. The computing device can also be configured to use position change detection methods to detect basket catheter movements inside or near the patient's heart, determine the three-dimensional coordinates X of each electrode for a given position and orientation of the basket within the patient's heart, determine and display to a user multiple positions of the basket inside or near the patient's heart, and provide a visual display to a user of the locations of the electrodes and/or basket inside or near the patient's heart.

An improved wearable device for detecting progression of Cardiac Amyloidosis based on changes in relative values of characteristics of P-wave and R-wave is disclosed. In an embodiment of the invention, two electrodes the device are connected to user's skin surface to obtain traces of ECG signals. Thereafter, correction factors are determined for the obtained traces of ECG signals. A microprocessor included in the device applies correction factors on the traces of ECG signals to obtain characteristics of P-wave and R-wave. Finally, the microprocessor determines the ratio of the characteristics (such as amplitude) of the P-wave to the characteristics (such as amplitude) of the R-wave and records said ratio. Still further, the microprocessor compares all such recorded ratios or features, to determine and display if there is disease progression.

An improved wearable device for detecting progression of Cardiac Amyloidosis based on changes in relative values of characteristics of P-wave and R-wave is disclosed. In an embodiment of the invention, two electrodes the device are connected to user's skin surface to obtain traces of ECG signals. Thereafter, correction factors are determined for the obtained traces of ECG signals. A microprocessor included in the device applies correction factors on the traces of ECG signals to obtain characteristics of P-wave and R-wave. Finally, the microprocessor determines the ratio of the characteristics (such as amplitude) of the P-wave to the characteristics (such as amplitude) of the R-wave and records said ratio. Still further, the microprocessor compares all such recorded ratios or features, to determine and display if there is disease progression.