A method for controlling a stimulation signal for brain stimulation comprises: transmitting a trigger signal for triggering a stimulation generator to output a high frequency synchronization signal exhibiting periodical modifications; receiving a measurement signal representing brain activity comprising neural oscillations and a response to the high frequency synchronization signal; determining adjustment of a phase of the stimulation signal based on a phase difference between the neural oscillations and the modifications of the high frequency synchronization signal; and transmitting a phase information signal for providing information of an adjusted phase of the stimulation signal to be used by the stimulation generator.

Systems and methods to access the functionally distributed network of the brain to allow for directly accessing, monitoring, and/or communicating with specific regions of the brain when interacting with an external device.

Systems and methods to access the functionally distributed network of the brain to allow for directly accessing, monitoring, and/or communicating with specific regions of the brain when interacting with an external device.

A system includes memory and processing circuitry coupled to the memory and configured to determine a plurality of local field potential (LFP) measurements of an LFP, wherein the LFP is intrinsically generated by a signal source within a brain of a patient, determine one or more electrodes for delivering a therapeutic electrical stimulation signal based on the LFP measurements, control stimulation generation circuitry to deliver a plurality of electrical stimulation signals via the determined one or more electrodes, wherein the plurality of electrical stimulation signals each comprise at least one different therapy parameter, for respective ones of the plurality of electrical stimulation signals, determine respective evoked signals, wherein the respective evoked signals are evoked by delivery of the respective plurality of electrical stimulation signals, and determine at least one parameter for the therapeutic electrical stimulation signal based on the respective evoked signals.

Methods and devices for computationally constructing brain potentials across whole brain using electrocorticography signals recorded from a small region on the brain surface are disclosed. In some embodiments of the disclosed technology, a method includes obtaining a plurality of locally recorded surface potentials from a plurality of first cortical areas of a brain surface; and performing a virtual reconstruction of an average brain activity for individual cortical areas and a pixel-level cortex-wide brain activity for a plurality of cortical areas of the brain surface including the plurality of first cortical areas based on the plurality of locally recorded surface potentials.

Methods and devices for computationally constructing brain potentials across whole brain using electrocorticography signals recorded from a small region on the brain surface are disclosed. In some embodiments of the disclosed technology, a method includes obtaining a plurality of locally recorded surface potentials from a plurality of first cortical areas of a brain surface; and performing a virtual reconstruction of an average brain activity for individual cortical areas and a pixel-level cortex-wide brain activity for a plurality of cortical areas of the brain surface including the plurality of first cortical areas based on the plurality of locally recorded surface potentials.

Provided are systems, methods, and devices for measurement, identification, and generation of sleep state models. Systems include a plurality of electrodes configured to be coupled to a brain of a user and configured to obtain a plurality of measurements from the brain of the user, and an interface configured to obtain the plurality of measurements from the plurality of electrodes. Systems include a processing device comprising one or more processors configured to generate a sleep state model associated with the user, the sleep state model identifying characteristics of a plurality of sleep stages, and further identifying characteristics of transitions between the plurality of sleep stages. Systems include a controller comprising one or more processors configured to generate a control signal based on the sleep state model and the plurality of measurements.

The present disclosure provides systems and methods for selecting contacts for use in deep brain stimulation (DBS). A computing device includes a processor and a memory device communicatively coupled to the processor. The memory device includes instructions that, when executed, cause the processor to apply a spatial filter to local field potential (LFP) recordings for a plurality of contacts of a DBS lead, calculate a power spectral density (PSD) for each contact from the filtered LFP for that contact, calculate a parametric approximation for each PSD, select at least one frequency band based on the parametric approximations, calculate a spectral coherency matrix for each of the at least one selected frequency band, and calculate an eigenvector centrality for each spectral coherency matrix to facilitate identifying a contact for stimulation.

The invention relates to a hybrid intracerebral electrode comprising a narrow, elongated body intended to be implanted in the brain of a patient in order to carry out at least one multi-scale electroencephalographic exploration. Said hybrid intracerebral electrode comprises, in its active part, a plurality of first electrical contact elements forming stationary macro-contacts, and a plurality of second electrical contact elements forming movable micro-contacts. The hybrid intracerebral electrode is characterised by control means which are built into the electrode in a coupling tip integral with the body. The control means are designed to move the second electrical contact elements between a passive position in which same are retracted inside the body and an active position in which same protrude outside the body, and simultaneously to adjust the controlled projection length thereof with respect to the body of the electrode.

The invention relates to a hybrid intracerebral electrode comprising a narrow, elongated body intended to be implanted in the brain of a patient in order to carry out at least one multi-scale electroencephalographic exploration. Said hybrid intracerebral electrode comprises, in its active part, a plurality of first electrical contact elements forming stationary macro-contacts, and a plurality of second electrical contact elements forming movable micro-contacts. The hybrid intracerebral electrode is characterised by control means which are built into the electrode in a coupling tip integral with the body. The control means are designed to move the second electrical contact elements between a passive position in which same are retracted inside the body and an active position in which same protrude outside the body, and simultaneously to adjust the controlled projection length thereof with respect to the body of the electrode.