In one embodiment, a method comprising: (a) receiving a set of physiological data associated with at least one health condition of an animal subject; (b) receiving a set of environmental data associated with one or more environment conditions to which the subject is or has been exposed; (c) determining a set of operating parameters for at least one environmental device based at least partially on at least a portion of the set of physiological data and at least a portion of the set of environmental data; and (d) transmitting the set of operating parameters to the at least one environmental device to at least partially control at least one controlled environmental condition to which the subject is exposed to thereby at partially control the at least one health condition.

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

A method and system for instructing a user behavior change comprising: collecting a first and a second bioelectrical signal dataset; generating an analysis based upon the first and the second bioelectrical signal datasets; and providing a behavior change suggestion to the user based upon the analysis. The method can further comprise collecting a third bioelectrical signal dataset associated with a performance of an action by the user in response to the behavior change suggestion; generating an adherence metric based upon the third bioelectrical signal dataset and at least one of the first and the second bioelectrical signal datasets; providing a stimulus configured to prompt an action by the user; and providing at least one of the analysis and an analysis based upon the adherence metric to the user. An embodiment of the system comprises a biosignal detector and a processor configured to implement an embodiment of the method.

By using an iterative loop of data collection, binaural tone generation/presentation, and analysis binaural tones can be introduced to induce an existing brain state to change from one associated with being awake to a state associated with being asleep. The current state of an individual's brain is determined by measuring movement and electrical activity. Using this data a binaural tone can be generated to induce the brain state to change. As the state of the brain is continually monitored the applied binaural tone is modified and applied until the desired sleep state is obtained.

Systems, devices and methods are described for physiological monitoring, for example monitoring EEG signals to detect the onset or probability of adverse events. The systems, devices and methods discussed herein may monitor received EEG signals to identify trends or patterns in the signal that are either indicative of ongoing seizures or indicative of a future risk of seizure. The systems, devices and methods provide the user with increased control and flexibility in the monitoring processes that produce the alerts. In particular, in some implementations the physician is able to make adjustments during monitoring and customize the process by which EEG data is displayed and analyzed during the patient monitoring without pausing the monitoring to make the adjustments.

The present invention provides a system and method for determining and maintaining a concentration level of medication in a patient sufficient to achieve and maintain a desired effect on that patient. Generally speaking, in accordance with one embodiment of the invention, a medication delivery controller uses a patient response profile to determine a concentration of medication in the patient that will achieve the desired effect on the patient. The patient response profile is a graphical, tabular or analytical expression of the relationship between the concentration of a medication and the effect of the medication at the specific concentration. Using this information, the medication delivery controller provides instructions to a medication delivery unit such as, for example, an infusion pump or inhalation device, to deliver the medication to the patient at a rate that will achieve the desired concentration level of the medication in the patient.

Trigeminal nerves are stimulated based upon pulse counting and chronobiology. A cutaneous electrode assembly is applied to the forehead to stimulate the ophthalmic nerves. A method may include determining a number of pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves with the determined number of pulses. Another method may include determining a pulse repetition frequency for pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves at the pulse repetition frequency.

A method of reducing cortical spreading depolarization in an animal having a brain injury includes: affixing to the animal one or more electrodes that are electrically connected to a neurostimulation device; and providing to the animal, by the neurostimulation device, via the one or more electrodes, electrical stimulation of the animal's trigeminal nerve, thereby reducing cortical spreading depolarization in the animal The method may reduce at least one detrimental effect of cortical spreading depolarization on the injured animal brain.

Devices and methods for electrical potential sensing and influencing are provided. The inventive devices include electroencephalography (EEG), electrocardiogram (EKG), photoplethysmography (PPG), electromyography (EMG), and temperature devices for measuring bio-activity signals from a body. The described devices are designed to include motion dampending, a hybrid non-contact and contact sensing surface and to optimise sensitivity in difficult sensing conditions, such as during movement, through obstructions like hair and clothing, while having a convenient and small form factor. The inventive devices provide for improved sensitivity, adaptability, and noise reduction when compared to other designs. Methods for influencing said bio signals with a device with a hybrid non-contact and contact sensing surface are also described.