Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

A method and an electrode for monitoring electrical activity in a nerve are provided along with a method of fabricating such an electrode. The electrode includes a cuff formed from a chronically-implantable material that, when implanted, extends at least partially around an external periphery of the nerve. A plurality of contacts are supported by the cuff to be arranged adjacent to different regions of the nerve distributed along a transverse direction of the nerve when the cuff is implanted. A multiplexer is coupled to the cuff to be implanted for receiving electrical signals introduced to the contacts by the nerve and multiplexing, in vivo, the electrical signals to be transmitted to an external receiver over a shared communication channel.

A method of reducing the likelihood of shivering comprises monitoring at least one physiological characteristic in a human or animal subject to detect preshivering and acting to reduce the likelihood of shivering when preshivering is detected.

The invention is directed to a method of generating and measuring transiently evoked otoacoustic emissions (TEOAE) acoustic signals generated in the cochlea using a scheme of stimulating both inner ears simultaneously, left ear alone, and right ears alone with at least two different first and second averaging buffers per ear in a switching scheme with automated detection of contralateral suppression of TEOAE via statistical analysis of the differences of suppressed and unsuppressed responses.

Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.

A system and method for denervation where a catheter includes a radially expandable member, the radially expandable member including an exterior surface, a plurality of electrodes on the exterior surface configured for delivery of energy during a denervation procedure in a vessel, and a chemical agent coating on the exterior surface, wherein the chemical agent inhibits or prevents nerve regeneration. The radially expandable member is configured to have a first unexpanded configuration and a second expanded configuration, and is configured to bring the exterior surface in contact with a wall of a vessel when it is in the expanded configuration.

A method of fitting a cochlear implant in an ipsilateral ear of a subject, the cochlear implant having an electrode array with one or more electrode contacts, includes applying broad-band white noise stimulus to a contralateral ear in order to mask efferent nerve fibers, applying a single pulse stimulus to the ipsilateral ear and then measuring base-line evoked compound action potential (CAP) signals in the ipsilateral ear for an electrode contact during a refractory period, applying a sequence of separated single pulse stimuli to the contralateral ear and then measuring attenuated CAP signals in the ipsilateral ear for the electrode contact during the refractory period, comparing the measured attenuated CAP signals to the measured base-line CAP signals in order to determine a CAP threshold for the electrode contact and adjusting processing parameters of the cochlear implant based on the CAP threshold.

A method of reducing the likelihood of shivering comprises monitoring at least one physiological characteristic in a human or animal subject to detect preshivering and acting to reduce the likelihood of shivering when preshivering is detected.

A speaking valve adapter is disclosed for assisting with speech or language expression during the respiratory recovery of a human. The speaking valve adapter including a speaking valve port, the port being orthogonal to a first interface port, the first interface port adapted to support tracheostomy or endotracheal tubing, a second interface port adapted to support at least one of a suction tubing and a bronchoscopy tubing, and a third interface port adapted to support a connection to a ventilator. The speaking valve adapter may be used by the patient for introduction of at least one of sounds and words while connected to the ventilator. A corresponding respiratory management system which implements the speaking valve adapter and configurable ventilator settings adapted for assisting with more effective speech or language expression during patient recovery or use is also disclosed.

Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal, for stimulating and/or sensing activity of media proximal to the device, wherein the media includes tissue and/or fluid.