The present invention is related to a vaginal drug delivery device and to a vaginal diagnostic device that comprises a first and second rigid member, wherein the first and/or second rigid member comprises a reservoir holding a medicament to be delivered, an opening, and a pump for pumping said medicament out of said opening, and/or wherein the first rigid member and/or second rigid member comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The device further comprises a first flexible member and flexible part, wherein at least one of the first flexible member and the flexible part is at least partially elastic having an elasticity such that the device can be squeezed from an extended shape to a collapsed shape. The device is pre-biased to assume the extended shape when little to no external force is being applied thereto. Furthermore, the device assumes a shape substantially corresponding to the extended shape when the device is inserted with the squeezed rigid member first, so that these naturally unfold in the formix posterior vaginae.

Provided herein are methods and kits for determining receptivity status of an endometrium for embryonic implantation.

An illustrated view of an exemplary endocervical labor induction medicine injection apparatus for administering medication prior to or in the early stages of childbirth. The endocervical labor induction medicine injection apparatus is a medication apparatus that provides for controlled insertion of tablet style medication in an endocervical or lower uterine body area. The endocervical labor induction medicine injection apparatus provides increased functionality over the current manual placement methods ensuring maximum benefit and reduction of unwanted side effects. The endocervical labor induction medicine injection apparatus has a guide tube and an ejector tube. The ejector tube has an ejector head with a receiving cavity at a distal end of the ejector tube for receiving and dispensing the medication. A wire couples the receiving cavity at the distal end to a handle at a proximal end of the ejector tube. The guide tube is inserted into the cervical cavity of a patient. After determining proper positioning and loading of the medication into the receiving cavity, the distal end of the ejector tube is slid through the guide tube. The handle is then manipulated to release the medication at the desired location.

A method and system of providing therapy to a patient's uterus is provided, which can include any number of features. The method can include the steps of inserting a uterine device into the uterus and performing a uterine integrity test to determine that the uterus is intact and not perforated. If it is determined that the uterus is not perforated, a patency test can be performed to determine that the uterine device is not clogged or embedded in tissue. If the uterus is intact and the device is not clogged or embedded in tissue, the uterus can be treated with the uterine device, e.g., uterine ablation. Systems for performing these methods are also disclosed.

Real-time localization system for minimal light surgical interventions, probe or fiber laser for internal surgery, composed of a probe or fiber optic laser, associated with the corresponding hysteroscope, an ultrasound machine with 3D technology and active image management, both associated with a control unit with a user interface and at least one screen for monitoring the location status of the optical fiber, for the emission of the laser and for the angle of incidence in the degree of temperature transfer to the myometrial wall, with the peculiarity that the ultrasound system has a system for guiding and monitoring its position on the skin layer of the patient, while the probe or optical fiber has a main fiber bundle for the transmission of the evaporation laser beam to a certain wavelength and at a certain power, modulated and controlled from the control unit, as well as a second beam of emission and reception bidirectional by rebound effect, pulsed laser for the practice of thermography, having provided that the control unit software includes means to obtain the positioning of the optical fiber based on the joint signals of the ultrasound machine, the internal probe and the system thermography associated with the second optical fiber bundle. Although the invention has been primarily intended to be applied in the field of myomatosis, the system of the invention is applicable to any type of minimal light surgical intervention in which probes or laser fibers are used.

A multi-lumen catheter for monitoring intrauterine pressure comprising an elongated body configured and dimensioned for insertion into a uterus of a patient, the catheter having a first lumen, a second lumen, and a first balloon at a distal portion. The first lumen communicates with the first balloon and the second lumen has an opening within the uterus for injection of x-ray dye or other fluid into the uterus for imaging the uterine cavity and the fallopian tubes of a patient. The first balloon contains a gas to form along with the first lumen a chamber to monitor pressure within the uterus to thereby determine if excessive pressure is being applied to the fallopian tubes of the patient. A sensor is in communication with the first lumen to measure pressure about a circumferential area of the balloon to measure pressure in the uterus to provide readings of intrauterine pressure.

A method and system of providing therapy to a patient's uterus is provided, which can include any number of features. The method can include the steps of inserting a uterine device into the uterus and performing a uterine integrity test to determine that the uterus is intact and not perforated. If it is determined that the uterus is not perforated, a patency test can be performed to determine that the uterine device is not clogged or embedded in tissue. If the uterus is intact and the device is not clogged or embedded in tissue, the uterus can be treated with the uterine device, e.g., uterine ablation. Systems for performing these methods are also disclosed.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

A monitoring system comprising: a uterine insert comprising an insert extension, wherein the insert extension comprises at least one sensor; a deployment module engageable with the insert, and configured to allow the insert extension to bend when the module is engaged with the insert; a system control device operationally coupled to continuously receive signals from the at least one sensor and to convert the signals into data representing the signals, and a display operationally coupled to display the data from the system control device.

This invention provides devices and methods for self-administered noninvasive retrieval of biological materials of the uterus and cervix, and preimplantation stage embryos. The procedure uses a Uterine Device, with a receptacle of variable volume, a controller configured to change the volume of the receptacle cavity, a flexible pouch for generation of suction to facilitate their retrieval, and an Absorption Capsule, which is a surface for collection of the above biological materials. The biological materials retrieved include cells and secretions, directly from the site of pathology, not metabolized or diluted in the body fluids, allow comprehensive analysis of various biomarkers of diseases and disorders of reproduction. Information generated by analyzing these biological materials permits early diagnosis and assessment of prognosis of diseases and disorders of the female reproductive organs, irregularities of pregnancy, anomalies of the fetus in utero, and microbial infections. The preimplantation stage embryos are recovered from normal subjects or those received treatment of gonadotrophins and/or other methods for induction of ovulation or superovulation to improve the yield of ovulated oocytes (ova). Multiple ova released from the ovaries travel through the fallopian tubes, which may be fertilized with sperms made available by artificial or normal insemination (copulation). The fertilized embryos divide and differentiate further into free preimplantation stage embryos at morula- and blastocyst-stages are deposited on the Absorption Capsule. These embryos, retrieved from the Absorption Capsule and may be processed by a variety of methods routinely utilized in the Assisted Reproductive procedures, including, screening for various genomic diseases, karyotype errors of trisomy and other chromosomal anomalies, and deleterious mutations. The screening procedures may involve Preimplantation Genetic Diagnosis (PGD) and Trophectoderm biopsy methods. Normal embryos free of disease potential are transferred to the mothers or surrogates for further in utero development. These procedures allow prevention of human birth defects and pre- and post-natal genomic diseases by selection of disease-free normal embryos for further in utero development, and possible cure of genomic diseases at this stage, in the future.