A non-invasive optical measurement system comprises a two-dimensional array of photonic integrated circuits (PICs) mechanically coupled to each other. Each PIC is configured for emitting sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure. Each PIC is further configured for detecting the signal light. The non-invasive optical measurement system further comprises processing circuitry configured for analyzing the detected signal light from each of the PICs, and based on this analysis, determining an occurrence and a three-dimensional spatial location of the physiological event in the anatomical structure.

A diagnostic method for monitoring changes in a fluid medium in a patient's head. The method includes positioning a transmitter at a first location on or near the patient's head, the transmitter generates and transmits a time-varying magnetic field into a fluid medium in the patient's head responsive to a first signal; positioning a receiver at a second location on or near the patient's head offset from the transmitter, the receiver generates a second signal responsive to a received magnetic field at the receiver; transmitting a time-varying magnetic field into the fluid medium in the patient's head in response to the first signal; receiving the transmitted magnetic field; generating the second signal responsive to the received magnetic field; and determining, a phase shift between the transmitted magnetic field and the received magnetic field for a plurality of frequencies of the transmitted time-varying magnetic field.

One variation of a system for locating electrodes on a head of a user includes a headset defining a set of electrode bodies elastically interconnected by a unique set of spring elements configured to locate the set of electrode bodies at electrode positions of the international 10-20 standard, irrespective of the size of the head of the user. The spring elements are configured to carry electrical signals between interconnected electrode bodies and ultimately to a controller. An electrode tip is mechanically and electrically coupled to each electrode body. The electrode tip comprises a thin conductive probe mounted at the distal end of an elastic beam and is configured to extend from a base of the electrode tip, bypass hair, and electrically couple to the head of the user, and an insulative boss, configured to rest on and transfer the weight of the headset to the head of the user.

Typically, high NREM stage N3 sleep detection accuracy is achieved using a frontal electrode referenced to an electrode at a distant location on the head (e.g., the mastoid, or the earlobe). For comfort and design considerations it is more convenient to have active and reference electrodes closely positioned on the frontal region of the head. This configuration, however, significantly attenuates the signal, which degrades sleep stage detection (e.g., N3) performance. The present disclosure describes a deep neural network (DNN) based solution developed to detect sleep using frontal electrodes only. N3 detection is enhanced through post-processing of the soft DNN outputs. Detection of slow-waves and sleep micro-arousals is accomplished using frequency domain thresholds. Volume modulation uses a high-frequency/low-frequency spectral ratio extracted from the frontal signal.

A device is provided for diagnostic measurement by simultaneous multimodal analysis of a subject's head wherein the cerebral blood flow variations as well as the concentration level of oxygenation in the subject's blood are used to determine the presence and the pathophysiology of neurocognitive disorders, including the neurodegenerative disease referred to as Alzheimer's disease.

An illustrative calibration member made from a material that scatters light may be used to perform a calibration operation with respect to an optical measurement device having a plurality of light sources and a plurality of detectors distributed among a plurality of modules. The calibration member may form an exterior surface configured to support the optical measurement device and scatter photons of light emitted by the optical measurement device. The calibration operation may be performed based on arrival times of the scattered photons detected by the optical measurement device.

Disclosed systems include a self-contained electroencephalogram (EEG) recording patch comprising a first electrode, a second electrode and wherein the first and second electrodes cooperate to measure a skin-electrode impedance, a substrate containing circuitry for generating an EEG signal from the measured skin-electrode impedance, amplifying the EEG signal, digitizing the EEG signal, and retrievably storing the EGG signal. The patch also comprises a power source and an enclosure that houses the substrate, the power source, and the first and second electrodes in a unitary package.

Apparatus for the non-invasive in-vivo determination of changes in tissue, e.g. the myelination, of the optic nerve (ON) in a biological subject, said apparatus comprising: a laser source for generating an excitation laser beam; an optical system including a fundus camera operatively associated with the laser source for use in obtaining a fundus image for illuminating the optic nerve (ON) of a subject with the excitation laser beam; a detector (13) operatively associated with the optical system and configured to detect a Raman spectrum from the optic nerve (ON) and/or surrounding cerebral spinal fluid; and a processor provided with a computer program for comparing the detected Raman spectrum to at least one reference spectrum. The reference spectrum may correspond to the myelination of the optic nerve in a normal, healthy subject, for determining the changes in the myelination of the optic nerve of the subject based on the detecting and comparing steps from the Raman spectrum.

The present technology relates to open respirator devices having sensors for measuring breath biometrics. For example, a respirator device (100) can include a mask component (102) that fits at least partially over a user's face and forms a gap (112) between a periphery of the mask component and the user's face, thereby forming a breathing chamber (108) between the mask portion and the user's face. A fan unit can provide air from the external environment to the breathing chamber for the user to inhale. In some embodiments, the air may be filtered before entering the breathing chamber and the fans may provide a positive pressure seal between across the gap. One or more sensors can be coupled to the mask component for measuring one or more metrics associated with the user's breath.

The invention relates to a stabilising head support for use by a patient during MRI scanning. The head support includes a shell and an inflatable bladder that is located at least partially within the shell. During use, the shell is located within an MRI magnet and the bladder is inflated about the patients head to help hold the head steady during imaging.