Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

A monitor for determining analyte concentrations in vivo, includes a housing configured to adhere to the skin of a subject, an elongate sensor body configured to extend from the housing into the skin of the subject, an analyte sensing region positioned on the sensor body such that the analyte sensing region is configured to be held in the dermis of the skin of the subject, and at least one engagement surface configured to facilitate increased anchoring of the sensor body in the skin of the subject.

A medical system comprising a patch device and a computer. The patch device is in communication with the computer. The patch device is configured for generating measurement data or providing a therapy. The patch device comprises electronic circuitry, a battery, an antenna system, one or more sensors, an IMU (inertial measurement unit), and a flexible enclosure. The antenna system can comprise a dual antenna formed on a dielectric substrate with a first antenna on a first side of the dielectric substrate and a second antenna on a second side of the dielectric substrate. The one or more sensors can comprise devices configured to provide measurement data or a therapy. The IMU is configured to measure position, movement, and trajectory of the patch device. The electronic circuitry is configured to harvest energy from one or more radio frequency signals received by the antenna system to recharge the battery.