An electrode module is positioned inside an intracranial portion of a human head. Then, it captures brain images of the human head so multiples two dimensional (2D) cross-sectional images are obtained. The electrodes can be seen in one or more 2D cross-sectional images. A brain functional map adjusting portion is provided to obtain the 2D cross-sectional images and then to conduct a proportional deformation process for the images in the brain functional map database. By combining the processed images in the brain functional map database and the 2D cross-sectional images, multiple combined cross-sectional images can be obtained for display. So, the effects of intracranial electrodes are better than the traditional way. In addition, the brain structure information of a patient contains the precise positions of the electrodes and the corresponding brain functional areas.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

A probe comprising a body portion and a tip portion. The body portion comprises: a first mounting portion comprising a plurality of first carriers, each first carrier being arranged to support an elongate first waveguide, the first carriers being disposed in an equiangular arrangement around a longitudinal axis of the body portion; a plurality of first waveguides, each first waveguide being supported in a respective one of the plurality of first carriers; and a body end fitting at which first ends of the first waveguides are supported in the equiangular arrangement around the longitudinal axis of the body portion such that the first waveguides can transmit electromagnetic radiation signals from an energy source to the body end fitting and/or transmit electromagnetic radiation signals from the body end fitting to a receiver. The tip portion comprises: a second mounting portion comprising a plurality of second carriers, each second carrier being arranged to support an elongate second waveguides, the second carriers being disposed in the equiangular arrangement around a longitudinal axis of the tip portion; a plurality of second waveguides, each second waveguides being supported in a respective one of the plurality of second carriers; and a tip end fitting at which first ends of the second waveguides are supported in the equiangular arrangement around the longitudinal axis of the tip portion; and an elongate conduit for piercing human tissue.

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Stimulation and recording electrode assemblies that are particularly useful for Automatic Period Stimulation (APS). Such embodiments are compatible with nerve monitoring systems to provide continuous stimulation of a nerve during surgery. Certain embodiments include an electrode assembly having cuff including a body and two ears extending from the body. Within the body, at least one electrode is supported and connected to a lead wire assembly. The ears can be brought together to enlarge a gap in the body so that the electrode assembly can be fixated around a nerve. Other embodiments include an electrode assembly including first and second needle electrodes that each have a tip. A body is provided to interconnect the needle electrodes and can be manipulated to move the tips either toward or away from one another. Disclosed embodiments provide nerve monitoring and stimulation in cases where the nerve is only partially dissected.

The invention provides improved devices and apparatuses and related methods for sensing differences in pressure or other parameters in the environment of the body of a patient during passage of the device through one or more tissues. In one aspect, the devices and apparatuses of the invention are configured to sense differences in the environment of the body of the patient as the device passes through tissue adjacent to the epidural space to tissue of the epidural space. In one aspect, a dual cannula device comprising one or more sensors connected to a signaling component is provided for sensing passage into of the device into the epidural space and positioning therein. Methods of using same are also provided.

A detection system can include a device, a circuit, and at least one indicator. The device can include polymer needle having a distal end and a proximal end. A needle lumen can be extended along a longitudinal axis of the polymer needle. The distal end can include an insertion tip. An elongate sleeve can include a first end and a second end. The polymer needle can be located within an inner bore of the elongate sleeve. The insertion tip of the polymer needle can be disposed at a distance from the elongate sleeve. A first electrode can be coupled to the device and a second electrode can be electrically isolated from the first electrode. The circuit can be configured to provide a signal based on an electrical characteristic between the first electrode and the second electrode. At least one indicator can be communicatively coupled to the circuit and configured to provide an output based on the signal.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

An insertion device includes a cover body, an insertion module. The insertion module is disposed in the cover body, and includes a main body, an insertion seat, a first elastic member, a retraction seat and a second elastic member. When the cover body is depressed, the insertion seat is driven by the first elastic member to perform an automatic-insertion operation and to collapse a limiting structure between the insertion seat and the cover body. A limiting structure between the insertion seat and the retraction seat collapses upon the collapse of the limiting structure between the insertion seat and the cover body, so that the retraction seat is driven by the second elastic member to perform an automatic-retraction operation.

A device for measuring a pressure differential comprises a tube, at least one pressure sensor and a processor. The tube comprises a closed insertion portion for insertion into a body, the insertion portion having an insertion end and an internal bore in communication with ambient pressure via an opening in the tube. The sensor is located in or on the insertion portion and comprises an internally facing region in communication with the bore and an externally facing region in communication with an exterior of the tube. The processor is configured to provide a stimulus, which may be an electrical stimulus, to the pressure sensor so that when the stimulus is provided, the pressure sensor provides a measurable response wherein the processor correlates the response with the pressure differential between the exterior of the tube and the bore. The measurable response may be indicative of a change in pressure differential between the exterior of the tube and the bore. There may be a plurality of pressure sensors, in which case at least two of the sensors may have different resonant frequencies at the same pressure differential. The insertion portion may comprise at least one aperture sealed by at least one pressure sensor. The pressure sensor may comprise an electromechanical or micro-electromechanical material and may comprises a piezoelectric and/or electrocapacitive sensor. The externally facing region of the pressure sensor may comprise a coating, which may be electrically insulative.