An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

A system and method for monitoring body chemistry of a user, the system comprising: a housing supporting: a microsensor comprising a first and second working electrode, a reference electrode, and a counter electrode, and configured to access interstitial fluid of the user, and an electronics subsystem comprising a signal conditioning module that receives a signal stream, from the microsensor, wherein the electronics subsystem is configured to detect an impedance signal derived from two of the first working electrode, the second working electrode, the reference electrode, and the counter electrode; and a processing subsystem comprising: a first module configured to generate an analysis indicative of an analyte parameter of the user and derived from the signal stream and the impedance signal, and a second module configured to transmit information derived from the analysis to the user, thereby facilitating monitoring of body chemistry of the user.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

In the invention, only light reflected by a portion in which a microneedle is disposed arrives on a photodetector, and light reflected by a portion in which the microneedle is not disposed does not arrive on the photodetector. Disclosed is a skin patch for measuring blood glucose including a patch including a skin attachment surface, a reaction layer which reacts with glycation products of skin, and a plurality of microneedles disposed on the skin attachment surface to guide the glycation products of the skin to the reaction layer and an optical trap which allows light, which is reflected by only one portion among a portion in which the microneedle is disposed and a portion in which the microneedle is not disposed when the light is emitted to the reaction layer, to pass therethrough, a method of manufacturing the same, and a blood glucose measuring apparatus using the same.

A method is presented for forming a nanowire electrode. The method includes forming a plurality of nanowires over a first substrate, depositing a conducting layer over the plurality of nanowires, forming solder bumps and electrical interconnections over a second flexible substrate, and integrating nanowire electrode arrays to the second flexible substrate. The plurality of nanowires are silicon (Si) nanowires, the Si nanowires used as probes to penetrate skin of a subject to achieve electrical biopotential signals. The plurality of nanowires are formed over the first substrate by metal-assisted chemical etching.

Wearable sensor patches, applicator systems for applying wearable sensor patches, and associated systems, devices, and methods are disclosed herein. In one embodiment, an applicator system includes a first applicator portion, a second applicator portion, a spring, and a trigger mechanism. The first applicator portion releasably retains a wearable sensor patch configured to detect a parameter of an analyte in fluid of a user. When the applicator system is in a loaded mode, the spring and the first applicator portion are positioned within the second applicator portion such that the spring is positioned between the first applicator portion and the second applicator portion. The trigger mechanism is configured to initiate a transition of the applicator system from the loaded mode to a released mode such that the spring accelerates the first applicator portion distally away from the second applicator portion to apply the wearable sensor patch to the user.

The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.

A blood glucose detection device includes a carrier body, a flow-guiding actuator, a microneedle patch, a sensor and a controlling chip. The carrier body has a liquid guiding channel, a compressing chamber and a liquid storage chamber. The flow-guiding actuator seals the compressing chamber. The microneedle patch is attached on the carrier body and has plural hollow microneedles. The sensor is disposed within the liquid storage chamber. The controlling chip is disposed on the carrier body. The plural hollow microneedles puncture the skin of a human subject with minimal invasion. The controlling chip controls the flow-guiding actuator to actuate and the tissue fluid is sucked into the liquid storage chamber through the plural hollow microneedles, whereby the sensor detects the blood glucose of the tissue fluid to generate and transmit the measured data to the controlling chip. The controlling chip can generate monitoring information by calculating the measured data.

Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.

Microneedles for analysis of analytes in body fluids may be manufactured from robust materials such as stainless steel by laser cutting at least the basic needle configuration, applying a coating to electrically insulate and/or assure biocompatibility of the needle, and forming electrodes on the needles via lithography or other processes (preferably after treatment of the coaled areas at which the electrodes are to be applied). Preferably, the needles have a depression formed therein from which the electrodes extend, and which contains a sensing medium which produces a measurable output in response to the local concentration of the analyte of interest Thus, when a needle is inserted into the skin such that the depression and its sensing medium encounters body fluids, analyte measurements can be obtained via the electrodes.