The invention relates to a position determining device for determining a position of an elongate object within a tubular structure, said position determining device comprising a first providing unit for providing a first distribution of curvature values at a plurality of first points along a path within the tubular structure. The position determining device further comprises a second providing unit for providing a second distribution of strain values or of curvature values at a plurality of points along the object, and a position determining unit for determining the position of the object relative to the path on the basis of the first and second distributions.

A mass spectrometry imaging system includes an ionization source located at a first location configured to produce ions from a surface of a sample at the first location; a mass spectrometer located at a second location configured to perform mass spectrometry analysis by analyzing the produced ions based on mass to charge ratio of the ions; and an ion transfer device configured to transfer the ions from the first location to the second location such that the ion transfer device includes a plurality of electrodes, the plurality of electrodes configured to be flexible or flexibly connected to each other, and the ion transfer device is configured to be flexible or re-configurable while transferring the ions.

There is described a method for calculating a patient-specific hemodynamic parameter. The method comprises measuring at least one pressure measurement in an artery using an intravascular pressure measurement device, and taking at least one medical image of the artery from a medical imaging instrument, the at least one medical image of the artery being synchronous with the at least one pressure measurement. Both the pressure measurement and the medical image are fed to a computing system to calculate a flow from the at least one medical image, to calculate parameters of the artery from at least two artery pressure drops and corresponding flow components, and based on the flow and the parameters of the artery, to calculate a patient-specific hemodynamic parameter or a plurality thereof.

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

A pressure guidewire is provided that includes an outer tube, a connector tube positioned radially inward of the outer tube, a pressure sensor assembly, and/or a distal tip at the distal end of the outer tube. A core wire may be positioned distal to the connector tube. The core wire may have a reduced diameter portion such as a tapered portion. The pressure sensor assembly may include a pressure sensor positioned distal of the connector tube, for example radially between a coil portion of the outer tube and the core wire. The pressure sensor assembly may also include one or more pressure wires leads extending from the pressure sensor and through the connector tube lumen.

Methods, devices and systems for location of the disposition of a medical probe in a subject are disclosed. An array of electromagnetic drive coil sets, each having two or three dimensionally oriented drive coils, a sensor coil being electromagnetically communicative with the array of electromagnetic drive coil sets, a discrete core wire providing response to electrical stimuli of the subject, and a controller communicative with and adapted to energize one or more of the electromagnetic coils in the array of electromagnetic drive coil sets are disclosed. Energizing of the one or more of the electromagnetic coils including one or more of energizing the coils singly, or in pairs of x-y and y-z or x-z coils while measuring the response of the sensor coil, whereby the system uses the measurements of the responses of the sensor coil to calculate the location of the sensor coil relative to said drive coil sets.

Multiple approaches to incorporating multiple conductors on a guidewire by building the multiple conductor traces of variable sizes and material compositions on separate insulating layers are described. The approaches described in the invention facilitate ease of assembly of sensors to the guidewire or catheter element. This approach is particularly useful in scenarios where electrical or mechanical properties of the device need to be altered in specific sections to either enhance device performance and reliability (e.g. selective abrasion resistance), or facilitate ease of assembly (e.g. soldering or connection ease), or in some instances achieve desired electrical characteristics (e.g. impedance). The desired properties are incorporated into the same device requiring an innovative approach to forming signal wires in an otherwise tight space without impacting the primary mechanical performance of the devices.

Systems and methods for locating a medical device in a body lumen are provided. A first flexible elongate instrument comprises a plurality of imaging markers, and a location information sensor is disposed at the first flexible elongate instrument or at a second flexible elongate instrument configured for relative movement with respect to the first flexible elongate instrument. A processor is configured to establish a reference coordinate system based on the plurality of imaging markers, which are visible in a medical image comprising the first flexible elongate instrument disposed in a body lumen, receive diagnostic scan or therapeutic delivery information at a plurality of locations of the body lumen from the first or second flexible elongate instrument, and correlate the information with the imaging markers. A display configured to display a composite image comprising the correlated diagnostic scan or therapeutic delivery information and the imaging markers.

Medical catheterization is carried out by introducing a catheter into a heart, sliding the catheter through a sheath that encloses a multi-electrode probe into a chamber of the heart. The sheath is retracted to expose the probe. As the sheath is retracted the exposed probe expands into a spiral configuration, and the electrodes contact the endocardial surface of the chamber at multiple contact points.

A system and method for determining the position of a non-shape-sensed guidewire (102) and for visualizing the guidewire. The system includes a shape-sensed catheter (104) having a lumen (103) that is configured to receive the non-shape-sensed guidewire. A measurement module (122) is configured to measure a distance that the non-shape-sensed guidewire moves. The measurement module may receive signals from a sensor (124) associated with a measurement assembly that is configured to receive at least a portion of the non-shape-sensed guidewire and/or the shape-sensed catheter. A location module (126) is configured to determine a position of the non-shape-sensed guidewire. The system is configured to generate a virtual image (101) of the guidewire, including a portion of the non-shape-sensed guidewire that does not extend along a shape-sensing optical fiber.