A wireless intraluminal device and an associated system for treating and diagnosing patients are provided. In one embodiment, the wireless intraluminal device includes a flexible elongate member including a proximal portion and a distal portion; a sensor assembly coupled to the distal portion of the flexible elongate member; a cable coupled to the sensor assembly and extending along the flexible elongate member; and a wireless transceiver positioned within the flexible elongate member, wherein the wireless transceiver is in communication with the sensor assembly via the cable. A wireless communication component wirelessly transmits a sensor measurement collected by the sensor assembly to a sensor measurement processing system via a wireless link for physiological data generation at the sensor measurement processing system.

One aspect relates to a guidewire system, a measuring system, and a method for manufacturing such guidewire system. The guidewire system includes a guidewire and a surface acoustic wave sensor device. A portion of a surface of the guidewire is coated by the surface acoustic wave sensor device. The surface acoustic wave sensor device may be configured for measuring a pressure change. The surface acoustic wave sensor device includes a piezoelectric substrate and a transducer. A thickness of the surface acoustic wave sensor device perpendicular to a longitudinal direction of the guidewire is smaller than 100 μm.

The invention provides improved devices and apparatuses and related methods for sensing differences in pressure or other parameters in the environment of the body of a patient during passage of the device through one or more tissues. In one aspect, the devices and apparatuses of the invention are configured to sense differences in the environment of the body of the patient as the device passes through tissue adjacent to the epidural space to tissue of the epidural space. In one aspect, a dual cannula device comprising one or more sensors connected to a signaling component is provided for sensing passage into of the device into the epidural space and positioning therein. Methods of using same are also provided.

An eavesdropping arrangement for acquiring a measured physiological variable of an individual includes a receiver and a communication interface in a housing separate from the receiver. The communication interface is positioned along a communication link between a first sensor, which is configured to measure aortic blood pressure and to provide a signal representing measured aortic blood pressure, and a central monitoring device configured to monitor the measured aortic blood pressure. The communication interface includes a connection to the communication link that permits the communication interface to eavesdrop on the signal representing measured aortic blood pressure such that information representing measured aortic blood pressure is sent to the receiver while allowing the central monitoring device to receive and use the signal representing measured aortic blood pressure.

An apparatus and method of manufacture includes a helical wire coil and a core wire. The core wire has a first wire portion and a second wire portion. The first wire portion of the core wire extends through the helical wire coil. The second wire portion of the core wire is intertwined with the first helical wire coil to fixedly secure the core wire relative to the first helical wire coil. The core wire is formed from a first material that is non-extensible. The core wire is fixedly secured relative to a distal portion of the helical wire coil such that the core wire inhibits longitudinal elongation of the helical wire coil along a longitudinal coil axis.

An intravascular system includes at least one pressure-sensing instrument sized and shaped for introduction into a vessel of a patient; a processing unit in communication with the pressure-sensing instrument, the processing unit configured to: obtain proximal pressure measurements for at least one cardiac cycle of the patient while the pressure-sensing instrument is positioned proximal of a stenosis of the vessel; obtain distal pressure measurements while the pressure-sensing instrument is positioned distal of the stenosis; select a diagnostic window within a cardiac cycle by identifying a change in sign of a slope associated with the proximal and/or distal pressure measurements, wherein the diagnostic window encompasses only a portion of the cardiac cycle of the patient; calculate a pressure ratio between the distal and proximal obtained during the diagnostic window; and output the calculated pressure ratio to a display device in communication with the processing unit.

A sensor guide wire device (200) for intravascular measurements of a physiological variable in a living body is disclosed. The sensor guide wire (200) may comprise a sensor element (213) and a connector unit (220). The connector unit (220) is attachable to a signal converting device (310). The sensor element (213) provides the signal converting device (310) with a signal indicative of a physiological variable sensed by the sensor element (213). Furthermore, the connector unit (220) comprises a battery (222). A system (300) comprising the sensor guide wire device (200) and the signal converting device (310) is also disclosed.

Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

A control circuit for a sensor provided in a long member which can be inserted into a lumen to measure the flow velocity of a fluid in the lumen and a measurement device. The control circuit includes a drive circuit supplying a drive current to the sensor. A leakage current detection circuit detects a leakage current and performs an output corresponding to the detected leakage current. The leakage current detection circuit outputs a detection signal in response to detection of a leakage current exceeding a threshold value. A stop circuit stopping supply of the drive current to the sensor by the detection signal is further provided.

Intravascular devices, systems, and methods are disclosed. In some embodiments, a guidewire system for treating a patient includes an internal sensor mount having a body and a first cutout extending through a wall of the body; a core wire secured to the internal sensor mount; a sensor assembly for detecting a physiological characteristic of a patient secured to the internal sensor mount; an external housing disposed about the internal sensor mount and including an opening in communication with the cutout of the internal sensor mount; a proximal flexible member secured to at least one of the internal sensor mount and the external housing; a first distal flexible member secured to at least one of the internal sensor mount and the external housing; and at least one conductor electrically coupled to the sensor assembly and extending proximally beyond the internal sensor mount through the proximal flexible member.