Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and/or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and/or degraded within the GI tract.

The capsule comprises a tubular body and a front-end unit with an helical screw for anchoring the capsule to a wall of a patient's organ. The front-end unit is mobile in relative axial rotation with respect to the tubular body. A disengageable frictional coupling member allows this relative rotation when, for implantation, the tubular body receives an external rotational stress, and that until a predetermined limit torque triggering the disengagement. At explantation, this disengagement is prevented to allow a joint rotation of the tubular body and of the front-end unit and the unscrewing of the helical screw. It is provided for that purpose two conjugated plates facing each other, with flat surfaces such as circular sectors offset in opposite directions with respect to a radial reference plane, in such a way as to form steps providing an anti-disengagement abutment function.

This disclosure is directed to devices, systems, and techniques for monitoring a patient condition. In some examples, a medical device system includes a medical device comprising a set of sensors. Additionally, the medical device system includes processing circuitry configured to identify, based on at least one signal of the set of signals, a time of an event corresponding to the patient and set a time window based on the time of the event. Additionally, the processing circuitry is configured to save, to a fall risk database in a memory, a set of data including one or more signals of the set of signals so that the fall risk database may be analyzed in order to determine a fall risk score corresponding to the patient, wherein the set of data corresponds to the time window.

To enable detection of a plurality of capsule ingestions, the ingestible capsules include a transmitter and processing hardware to generate and transmit the signals. Each ingestible capsule obtains a serial number for distinguishing between the ingestible capsules, and generates a signal indicating that the capsule has been ingested. The signal includes a series of pulses having a particular pulse space and indicating the serial number. Each ingestible capsule transmits the signal to a receiver via the transmitter, where each ingestible capsule is identified based on at least one of: the particular pulse space and the serial number for the ingestible capsule.

Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane.

A patch configured for being applied to a patients skin, said patch comprising a contact area configured for being in direct contact with the patients skin when applied thereto, and a detector configured for detecting contact between the contact area and the patients skin.

An ingestible electronic capsule for the collection of samples along a gastric intestinal tract and methods relating thereto are provided. The ingestible electronic capsule includes a housing and a cap that form an interior chamber. The cap includes a sampling port and one or more sample collection chambers are disposed within the interior chamber. A motor is also disposed within the interior chamber and is configured to rotate one of the cap and the one or more sample collection chambers so to align one or the one or more sample collection chambers and the sampling port of the cap so to allow for sample collection. A microcontroller is also disposed within the interior chamber and is in communication with at least the motor. The microcontroller is configured to control the selective alignment of the sampling port and one of the one or more sample collection chambers and induce gastric intestinal fluid sampling.

Introduced here is a digital pill comprised of a capsule, an ingestible sensor, and a slot antenna. The ingestible sensor can be configured to generate a signal indicative of a characteristic of the living body in which the digital pill is located. Biometric data can be stored, at least temporarily, in a memory in the form of signal values. For example, the slot antenna may transmit biometric data to a computing device across a network on a periodic basis (e.g., every 5 minutes, 15 minutes, 60 minutes, etc.). Alternatively, the slot antenna may stream biometric data to a computing device across the network in real time.

A vibrating gastrointestinal capsule and method of use thereof for treating Parkinsonism in a subject, the method including: (a) providing a vibrating gastrointestinal capsule having a housing; a vibrating agitation mechanism adapted such that, in a vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; and a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; (b) ingesting the capsule, by the subject; and (c) controlling the vibrating agitation mechanism such that at least a portion of the vibrating mode of operation occurs within the stomach and/or the small intestine of the subject.

The present invention is directed to a miniaturized biosensor and nanotechnology which is embedded in a variety of medical devices which can be used for real-time device location tracking and analysis, for the purpose of optimizing device positioning both at the time of initial placement and throughout its clinical use (i.e., device continuum). The continuously acquired device-specific standardized data is then transmitted through wireless communication networks to provide continuous feedback and alerts to authorized clinical providers as to device positioning, clinical performance, and presence of pathology.