The invention provides a stepping doser. The doser comprises a bearing component, a dosing catheter, wiring tubes, a threaded rod, a nut, a signal recorder and a connecting rod; wherein the middle socket of the threaded rod is sheathed with a nut, the lower end of the threaded rod contacts the lower inner wall of the bearing component, the upper end of the threaded rod penetrates the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; The bearing component is also provided with a limit stop for limiting the rotation of the nut so that when the threaded rod rotates, the nut can move up and down; when the nut moves up and down, the dosing catheter can move up and down. The dosing catheter can be stepped with this doser, allowing dosing in a larger area.

One aspect of the present disclosure includes a closed-loop therapy delivery system for regulating an endogenous level of a first neuromodulatory agent in a subject. The therapy delivery system includes a sensing component, a delivery component, and a controller. The sensing component is configured to detect an extracellular level of the first neuromodulatory agent. The delivery component is configured to deliver an amount of a second neuromodulatory agent to an intraparenchymal target site of the subject. The controller is configured to coordinate operation of the sensing component and the delivery component.

An intraoperative multichannel brain probe is presented. The brain probe has a cylindrical upper stainless steel section attached to a lower cylindrical section. In the lower section, an outer cylindrical tube surrounds a second insulating tube. Electrically recording/stimulating wires are placed between the outer tube and the second tube. Each wire has one end protruding out a hole in the outer tube. The other end of each wire is threaded through the entire probe and electrically connected to a recording or stimulating device through a connector system. A number of insulating tubes and electrodes located inside the second tube may also be part of the brain probe. Each inner electrode, typically two, is insulated from each other and from the second insulating tube by other insulating tubes. The combination of one or more wires and electrodes provides a multi-functional device. The brain probe is capable of providing multichannel stimulation and/or recording of brain functions and up to 128 individual electrode conducting sites.

A method is described for determining an optimal placement location for an auditory brainstem implant (ABI) electrode array. A cochlear implant (CI) electrode array is inserted into a patient cochlea, and the ABI electrode array is initially placed at an initial placement location on a patient brainstem. The optimal placement location for the ABI electrode array is then determined by, for multiple electrode contacts on the ABI electrode array: i. selecting a specific electrode contact, ii. delivering a stimulation signal to the selected electrode contact, iii. sensing an efferent nerve signal from the stimulation signal using the electrode contacts of the CI electrode array, and iv. determining a maximum response location in the patient cochlea where a largest efferent nerve signal is sensed. The ABI electrode array is then repositioned to the optimal placement location.

The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.

An optical electrode having a plurality of electrodes, including a recording electrode having a roughened surface and an optical light source configured to emit light, wherein at least a portion of the light impinges on the recording electrode. Also disclosed are methods of producing an optical electrode and an opto-electronic neural interface system.

Provided herein is a method of optically recording neural activity in one or more regions of a target tissue. Also provided is a method of optically modulating the activity of a neural tissue. Further provided is a system that finds use in performing the present methods.

The temporal correlation between a bioelectrical brain signal of a patient and patient motion data, such as a signal indicative of patient motion or a patient posture indicator, is displayed by a display device. In some examples, the patient posture indicator comprises a graphical representation of at least a portion of a body of the patient. In some examples, the temporal correlation between a bioelectrical brain signal, a signal indicative of patient motion, and a signal indicative of cardiac activity of the patient is displayed by the display device.

A brain navigation device, comprising a lead with an elongated lead body, at least one macro-electrode contact positioned on an outer surface on the lead, wherein the at least one macro-electrode contact is located at the distal part of the lead, and wherein the at least one macro-electrode contact is configured to be used during lead navigation.

A method for assessment of brain signals of a patient includes determining, by one or more processors, a cluster of neural data occurring at a brain of the patient and outputting, by the one or more processors, a request for a user to provide patient state information for the cluster of the neural data in response to determining that the cluster of the neural data is occurring at the brain of the patient. The method further includes associating, by the one or more processors, the patient state information with the cluster of the neural data to generate patient assessment information and outputting, by the one or more processors, the patient assessment information.