A probe insertion device for implanting a probe into tissue includes a rigid base that selectively attaches to the probe due to a bond between the base and the probe, that provides a structural backbone to the probe, is longitudinally aligned with the probe, and can be adapted to receive a fluid between the base and the probe. The probe insertion device can include a surface covering at least a portion of the base that reduces the bond between the base and the probe in the presence of the fluid.

A sub-skin-depth (nanoscale metallization) thin film antenna is shown that is monolithically integrated with an array of neural recording electrodes on a flexible polymer substrate. The structure is intended for long-term biometric data and power transfer such as electrocorticographic neural recording in a wireless brain-machine interface system. The system includes a microfabricated thin-film electrode array and a loop antenna patterned in the same microfabrication process, on the same or on separate conductor layers designed to be bonded to an ultra-low power ASIC.

A thalamic medical device system enables automated detection of epileptic seizures and optionally providing contingent thalamic stimulation triggered by automated seizure detection. The thalamic medical device system includes an implantable medical device connected to an electrode assembly and a lead. The electrode assembly has at least one electrode surgically implanted into an anterior thalamic nuclei or a centro-median thalamic nuclei of a brain. The implanted medical device is configured to detect electrical signals and analyze detected electrical signals using a seizure detection algorithm, and further configured to deliver electrical stimulation to the anterior thalamic nuclei or centro-median thalamic nuclei via the electrode assembly when a seizure is detected.

Provided herein is a coated biosensor and a method of preserving a coated biosensor to protect it during implantation into the brain or other tissues by coating the biosensor with a protective coating.

An apparatus and method is provided for intraoperative tissue stimulation during port-based surgery. The apparatus includes an access port and electrical terminals attached to the access port for tissue stimulation. In an alternative embodiment, the apparatus may include an access port, with or without electrical terminals attached to the access port for tissue stimulation, and electrocorticography sensors attached to the access port. The method includes inserting an access port into a tissue, applying an electrical potential to the tissue using electrical terminals attached to the access port, and measuring consequent neural activity using electrocorticography sensors attached to the access port.

Embodiments may provide multimodal diagnostic systems and methods for detecting neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, PTSD, schizophrenia, dementia and many others. For example, a system for monitoring brain activity may comprise a plurality of sensors, each adapted to monitor a physical or physiological parameter and output a signal representing the monitored physical or physiological parameter, wherein the plurality of sensors includes at least one sensor configured to monitor a brain activity parameter, a data collection device adapted to receive the plurality of signals from the plurality of sensors and to process the signals to form digital data representing the monitored physical or physiological parameters, and a data processing device adapted to process digital data representing the monitored physical or physiological parameters to determine presence of a neurological disorder or condition.

Disclosed here are two approaches for implementing neural probes that consist of a thin, high-density Parylene C-based probe on a stainless steel shuttle. In a first approach, the high density Parylene C probe is microfabricated separately and is then affixed to a planar or curved stainless steel shuttle. In a second approach, the high-density probe is monolithically fabricated on a stainless steel shuttle by micromachining the stainless steel substrate.

The present invention provides a removable optical imaging device cap for use with a near infrared (NIR) light optical imaging device for detecting intracranial hematoma.

A processing device receives signals associated with nerve impulses that are transmitted to the visual cortex of a subject in response to one or more visual stimuli provided to at least one eye of the subject. The processing device processes the received signals and generates digital image data from the processed received signals that is representative of the visual perception, by the subject, of the one or more visual stimuli. In certain embodiments, the processing device processes digital image data that is representative of a scene to convert the digital image data to a sequence of nerve impulses, and provides the sequence of nerve impulses to the visual cortex of a subject such that the subject visually perceives the scene.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same