A neural interface arrangement has multiple probes for subdural implantation into or onto a human brain. Each probe has at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the electrode(s), and a transmitter for wirelessly transmitting data signals arising from the electrode(s). An array of coils is implanted above the dura beneath the skull, for inductively coupling with the coil of each probe, and for transmitting power to the probes. A primary coil is connected to the coil array, for inductively coupling with an external transmitter device, and for receiving power from the external transmitter device. In use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the coil array to transmit power to the probes by inductive coupling, and the probes wirelessly transmit data signals arising from the electrodes.

An optogenetic system and method for preventing or halting seizures. The system and method use a sensor for monitoring the activity of a neural network containing a group of target neurons, and generating an input signal indicative of said activity, the target neurons being excitatory neurons. Excitatory stimulation is delivered in the form of an optical signal by an optical stimulator to the target neurons, the optical signal being determined based on the input signal, to reduce the overall activity of the target neurons.

A multi-site probe for interfacing with the central nervous system includes one more structures disposed perpendicularly on a backing layer, where each structure includes a braided sleeve over a flexible or rigid core, and a delivery-vehicle. The structures may include optrodes and electrodes. The location of the probe may be determined through the application of combinatorics.

Embodiments for a cerebrospinal fluid flow detector for detecting the flow of cerebrospinal fluid are disclosed. In some embodiments, the cerebrospinal fluid flow detector includes a casing with a rotatable wheel having a plurality of radially extending arms disposed therein. The rotatable wheel is in communication with a channel having a distal end in communication with an inlet port and a proximal end in communication with an outlet port such that the flow of cerebrospinal fluid through the channel causes the rotatable wheel to rotate. In some embodiments, each radially extending arm includes at least one radiopaque marker in which movement of the rotatable wheel caused by fluid flow through the channel allows an X-ray imaging apparatus to detect the difference in position of a respective radiopaque marker at multiple times caused by rotation of the rotatable wheel.

A location pad includes multiple field-generators and a frame. The multiple field-generators are configured to generate respective magnetic fields in a region-of-interest of a patient organ, so as to measure a position of a medical instrument in the region-of-interest. The frame is transparent to an X-ray radiation, and is configured to fix the multiple field-generators at respective positions surrounding the region-of-interest.

Embodiments of the present systems and methods may provide a non-invasive system to measure and integrate behavioral and cognitive features enabling early detection and progression tracking of degenerative disease. For example, a method of detecting neurodegenerative disease may comprise measuring functioning of at least one of the motor system, cognitive function, and brain activity of a subject during everyday life and analyzing the gathered at least one motor system data, cognitive function data, and brain activity data of the subject.

A silent communication system (100) for communication between a first person (22) having a speech motor cortex (12) and a second person (24) employs a speech motor cortex neural sensing device (120) and senses speech neural impulses generated by the first person (22) who is generating motor neural potentials corresponding to speech. A wireless transmission device (122) is disposed on the first person (22) and communicates with the speech motor cortex neural sensing device (120). The wireless transmission device (122) generates a radio frequency signal corresponding to the speech neural impulses. A speech generating device (130) is disposed on he second person (24) and is responsive to the radio frequency signal. The speech generating device (130) generates a reconstruction of the speech of the first person (22) that is audibly perceptible by the second person (24).

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

An electrophysiological monitoring system includes an electrophysiology amplifier chip configured to couple to a plurality of electrophysiological electrodes and to measure electrophysiological signals. The system also includes a computing device configured to receive and to process the electrophysiological signals. The system further includes an interface device coupled to the electrophysiological amplifier chip and the computing device, the interface device configured to convert communication signals between the computing device and the electrophysiology amplifier chip.

A deep intracranial electrode which comprises a flexible wire, an electrode contact, a connector and a shield sleeve, one end of the flexible wire is connected to the electrode contact, the other end connected to the connector; the shield sleeve sheathes around the flexible wire, a sum of a length of a part of the flexible wire arranged outside the shield sleeve and a length of the shield sleeve being adjustable. When the shield sleeve sheaths around the flexible wire, the length of the flexible wire inside the radio-frequency magnetic field of the magnetic resonance equipment may equal to a sum of the length of the shield sleeve and a length of the flexible wire outside the shield sleeve.