An optical tissue imaging system includes a probe for insertion into a transparent cylindrical capillary. The capillary includes an internal cylindrical channel that extends along a central axis. The capillary is inserted into tissue of a subject, and the probe may rotate and translate within the capillary. The probe may include a mirror configured to reflect light to the tissue outside of the cylindrical capillary.

A location pad includes multiple field-generators and a frame. The multiple field-generators are configured to generate respective magnetic fields in a region-of-interest of a patient organ, so as to measure a position of a medical instrument in the region-of-interest. The frame is transparent to an X-ray radiation, and is configured to fix the multiple field-generators at respective positions surrounding the region-of-interest.

Brain drainage device having a rod-shaped hollow body with an inner drainage channel for insertion through the cranium into the brain, a first sensor arrangement with at least one sensor for measuring a physical parameter, and a signal interface; wherein the rod-shaped hollow body has a first region A which configured to protrude into the ventricle situated in the brain; wherein the rod-shaped hollow body has a second region B, which is arranged proximally from the first region, wherein the second region is configured to lie in the region of the brain mass; wherein the first sensor arrangement is arranged in the second region in order to measure a physical parameter of the brain mass; wherein the first sensor arrangement is connected to the signal interface such that measurement data determined by the first sensor arrangement are transmitted to a measuring system.

Disclosed is a stent-mesh and microelectrode assembly that is deployable using a catheter or cannula to form a neural interface for recording and/or stimulation of neural tissue. In some embodiments, the assembly may include a thin-film microelectrode array attached to a spring-like stent-mesh component. The thin-film microelectrode array may include an electrode body having two lateral wing-like appendages located distal to a thin-film flexible cable that terminates at the proximal end in a thin-film connector region. The stent-mesh may be attached to the thin-film microelectrode array and configured to be advanced to a target area in a collapsed state and then expanded after reaching the target area to transition the thin-film microelectrode array to a deployed configuration. Accordingly, the assembly may deliver the thin-film microelectrode array to a target area in a minimally invasive manner.

An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cell's normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMD's. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMD's. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.

A processing subsystem generates perceived images from information bearing nerve impulses that are transmitted from a subject's eye(s) to a visual processing region of the subject's brain along one or more nerves in response to the subject viewing a real-world scene. The processing subsystem generates display images based on the perceived images, and controls a display device to display the display images to the subject. In certain embodiments, the processing subsystem generates the display images by manipulating or modifying the perceived images to include virtual images, and provides a type of virtual pointing on the display images that is used to invoke one or more actions.

A method of neurostimulation includes applying a probe signal to an electrode implanted in or near a target neural structure of the brain. The method further includes detecting a first response from the target neural structure evoked by the probe signal and determining a first time period between application of the probe signal and a first temporal feature of the response. Further, the method includes generating a therapeutic signal comprising a plurality of pulses, at least two of the plurality of pulses separated by the first time period, and applying the therapeutic signal to the electrode or another electrode implanted in or near the target neural structure.

A system includes spatially isolated nodes proximal to a cortical surface or spinal cord, a telemetric antenna array located above the dura, the telemetric antenna array configured to provide power to and exchange data with the spatially isolated nodes, and a power and data distribution unit configured to power the spatially isolated nodes, aggregate recorded data, send the aggregated recorded data and commands through a wireless link.

Systems and methods for treating cancerous tumors (including glioblastoma multiforme (GBM)) with electrotherapy, such as deep brain stimulation (DBS) technology, as disclosed herein. One or more configurations can be generated based on a patients tumor characteristics. The selected configurations can be electrode configurations or settings for an electrical source coupled to the electrodes. The one or more configurations can be targeted for inhibiting cell growth process, such as to inhibit mitosis, immune suppression, or to inhibit DNA replication. Inhibition of cell growth processes can initiate death of the cancerous cells.

Provided herein are cranial implant devices that include at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials. The cranial implant devices are structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject and typically includes a substantially anatomically-compatible shape. In addition, the cranial implant devices permit transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the cranial opening of the subject. Other aspects are directed to various related systems and methods of obtaining diagnostic information from, and/or administering therapy to, a subject.