Method and apparatus for illuminating and imaging tissue is provided. In one version, the method includes illuminating a volume of a tissue with photons from a three-dimensional array of optical emitters inserted into the tissue. In another version, the method includes detecting photons from a volume of a tissue using a three-dimensional array of optical detectors inserted into the tissue. A probe device for illuminating tissue and/or detecting photons emitted from tissue includes elongated microsized probes containing optical emitters and optical detectors in a three dimensional array.

This invention is in relation to a thermosensitive plate for qualitative measurement of the component temperature of living organisms by means of thermosensitive silica used in the field of medical surgery.

The present invention relates to a syringe-injection-type brain signal measurement and stimulation structure, and a syringe injection method therefor, and provides a structure including a high-performance flexible element capable of minimizing a skull opening when inserted into the brain. Particularly, the present invention comprises: a flexible element, which includes a contact part making contact with a surface of a cortex so as to measure a signal generated in the brain or transmit an external stimulus to the brain, a transmitting/receiving part positioned between a skull and a skin, and a connection part for making a connection between the contact part and the transmitting/receiving part; and an integrated circuit connected to the transmitting/receiving part so as to transmit/receive a signal,

Systems and methods to access the functionally distributed network of the brain to allow for directly accessing, monitoring, and/or communicating with specific regions of the brain when interacting with an external device.

Embodiments of the invention are directed to a system for detecting neurotransmitters. A non-limiting example of the system includes a porous electrode. A system can also include a pH sensor attached to the porous electrode, wherein the pH sensor includes a sensing electrode and a reference electrode. The system can also include electronic circuitry in communication with the pH sensor.

A system for implantable automatic wireless intracranial pressure (ICP) monitoring is disclosed, including a control device and an implantable pressure transducer assembly. The implantable pressure transducer assembly is configured to be partially implanted in a skull of an individual being monitored, and the control device communicates and transfers data with the implantable pressure transducer assembly in a wireless manner. The system for implantable automatic wireless ICP monitoring can achieve easy and rapid ICP monitoring and entails a one-to-multiple mode in which multiple individuals can be simultaneously monitored by the single system based on wireless communications in WiFi, Bluetooth or a non-standard protocol.

A cannula with a proximally mounted camera provides visualization of the brain during minimally invasive surgery. The device comprises a cannula with a camera mounted on the proximal end of the cannula with a view into the cannula lumen and the surgical field below the lumen. A prism, reflector or other suitable optical element is oriented between the camera and the lumen of the cannula to afford the camera a view into the cannula while minimizing obstruction of the lumen.

A device to make multiple, simultaneous measurements of electrical activity on neural, muscular and other animal cells. The invention discloses multiple electrodes at fixed position on a supporting structure and multiple wires to connect the electrodes to one or more measuring devices. The electrodes are preferentially closed spaced, to allow for small spatial discrimination between measurement points. The electrodes and the wires are selected by binary addresses. The device is also capable of injecting electrical stimulation using electrodes not in use for measurements. An injected electrical stimulation at a first location may be created to measure the effect of a well-known event at another location or locations, near or far away.

The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

A neural interface arrangement comprising: a plurality of probes for subdural implantation into or onto a human brain, each probe including at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the sensing electrode(s), and means for wirelessly transmitting data-carrying signals arising from the sensing electrode(s); an array of coils for implantation above the dura, beneath the skull, the array of coils being for inductively coupling with the coil of each of the plurality of probes, for transmitting power to the probes; and a primary (e.g. subcutaneous) coil connected to the array of coils, the primary coil being for inductively coupling with an external transmitter device, for receiving power from the external transmitter device; wherein, in use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the array of coils to transmit power to the plurality of probes by inductive coupling; and wherein, in use, the plurality of probes are operable to wirelessly transmit data-carrying signals arising from the sensing electrodes.