Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, locating, tracking, monitoring, deflating, and retrieving the same are provided.

A system for treating a gastrointestinal tract may include a device configured to measure electrical activity at a plurality of locations within a gastrointestinal tract of a patient, a controller configured to compare the measured activity from the plurality of locations to a database of electrical activity corresponding to one or more gastric events, abnormalities, or dysrhythmias. The controller may be configured to determine one or more treatment locations based on the comparison, and cause the device to deliver therapy to the one or more treatment locations.

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

The device, that can be implanted in the intestinal cavity, comprises a reactor comprising a semi-permeable or porous membrane or coating linked to a element for attachment to an intestinal or gastric wall. The reactor can be in the form of a ribbon, a structure having more than two faces or an open structure delimiting a lumen, comprising, or formed from, a semi-permeable or porous membrane. The reactor can also delimit, at least partially with the semi-permeable or porous membrane of same, a closed inner space. The reactor can comprise or carry enzymes or micro-organisms, in particular bacteria or yeast. The reactor is used for generating a chemical reaction with one or more molecules present in the intestine, or for producing one or more biologically active molecules. It can, in particular, be used for consuming sugars, disaccharides and simple sugars or producing essential amino acids or other molecules having a positive effect on the health.

A device for measuring an internal dimension of a native cardiac valve annulus includes an elongated support member having a proximal portion and a distal portion. A measuring portion is coupled to the distal portion, and an indicator is coupled to the proximal portion of the support member. The measuring portion is biased towards a deployed configuration such that when deployed it applies an outwardly directed radial force to the native valve annulus.

Systems and methods for gastrointestinal electrical stimulation to treat abnormalities in gastrointestinal motility are provided. In some embodiments, a system for relieving ileus includes an intraluminal catheter comprising: a catheter body having a proximal tip and a distal tip and a duodenal portion proximal to the distal tip of the catheter; and at least one electrode pair disposed along the duodenal portion of the intraluminal catheter, the at least one electrode pair being configured to detect a sensing information indicative of myoelectric activity of a patient and to provide stimulation energy; a sensing system in communication with the at least one electrode pair to receive the sensing information; and an energy delivery system in communication with the at least one electrode pair and the sensing system, the electrical energy delivery system being configured to delivery energy to the patient through the at least one second electrode pair based on the sensing information from the sensing system.

The invention relates to a closed loop system which is used in modulating gastric activity. By appropriate deployment of the components of the system, one can monitor and modulate slow waves in the gastrointestinal system of a subject.

The present disclosure relates to injectable compositions sterile injectable fluid compositions comprising a polysaccharide having a color in the visible spectrum, methods of forming the same, kits containing the same, and methods for performing agent-assisted procedures in a patient using the same.

According to an aspect of the present inventive concept there is provided a device for analyzing a characteristic of an analyte in a test liquid, the device comprising: a reservoir configured to hold an analysis liquid, the analysis liquid comprising an analysis compound; a microfluidic channel having a first end and a second end, wherein the first end is arranged in fluid communication with the reservoir, wherein the second end is configured to be in fluid communication with the test liquid; wherein the microfluidic channel is configured to allow mixing, by diffusion, of the analysis compound entering the first end with the analyte entering the microfluidic channel from the second end; and a detector arranged in relation to the microfluidic channel, wherein the detector is configured to detect a property dependent on the mixing of the analysis compound and the analyte, said property being representative of the characteristic of the analyte in the test liquid.

Devices and methods to measure gastric residual volume (GRV) are described where at least one additive component (a GRV indicator) may be dispersed in a body lumen such as a stomach. The GRV indicator may changes a physical (chemical, electrical, thermal, mechanical, optical, etc.) characteristic within the stomach by a measureable degree. This degree of change and/or the rate of return to the previous state, may be used to determine the GRV of a patient. The determined GRV can also be used to automatically or semi-automatically control the patient's feeding rate and/or volume and/or frequency to adequately nourish the patient but avoid complications. The physical characteristic(s) may also be used to detect that the feeding catheter or tube is in the correct location (ie stomach vs lung or esophagus.