Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

The present invention is related to a vaginal drug delivery device and to a vaginal diagnostic device that comprises a first and second rigid member, wherein the first and/or second rigid member comprises a reservoir holding a medicament to be delivered, an opening, and a pump for pumping said medicament out of said opening, and/or wherein the first rigid member and/or second rigid member comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The device further comprises a first flexible member and flexible part, wherein at least one of the first flexible member and the flexible part is at least partially elastic having an elasticity such that the device can be squeezed from an extended shape to a collapsed shape. The device is pre-biased to assume the extended shape when little to no external force is being applied thereto. Furthermore, the device assumes a shape substantially corresponding to the extended shape when the device is inserted with the squeezed rigid member first, so that these naturally unfold in the formix posterior vaginae.

The present invention is related to a vaginal drug delivery device and to a vaginal diagnostic device that comprises a first and second rigid member, wherein the first and/or second rigid member comprises a reservoir holding a medicament to be delivered, an opening, and a pump for pumping said medicament out of said opening, and/or wherein the first rigid member and/or second rigid member comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The device further comprises a first flexible member and flexible part, wherein at least one of the first flexible member and the flexible part is at least partially elastic having an elasticity such that the device can be squeezed from an extended shape to a collapsed shape. The device is pre-biased to assume the extended shape when little to no external force is being applied thereto. Furthermore, the device assumes a shape substantially corresponding to the extended shape when the device is inserted with the squeezed rigid member first, so that these naturally unfold in the formix posterior vaginae.

Devices, systems and related methods for direct and in-vivo monitoring and stimulation of the endometrial cavity include a plurality of sensing modalities incorporated on a set of flexible conductive filaments that allows its insertion in an endometrial cavity through the vagina. The flexible set of conductive filaments is in direct contact with the endometrium to maximize recording sensitivity and acquire direct readings, which correspond to the functionality of the endometrium and/or electrically stimulate endometrial peristalsis in a controlled manner. The same electrodes can be used for a controlled stimulation to strengthen weakened muscle tissue before and after medical and surgical interventions on the uterus, to reset to normal contractility. The methods and systems disclosed herein can be used to improve the chances of success for artificial insemination, including in-vitro fertilization, embryo transfer, and intrauterine insemination, diagnostic tests, and may further improve the overall understanding of endometrial functionality.

A falloposcope is described, and a method of screening a patient for fallopian tube and/or ovarian cancer with the falloposcope. The falloposcope can perform optical imaging, including fluorescence imaging and/or optical coherence tomography (OCT), and optionally include a channel for a sampling wire, within a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube so a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing fluorescence stimulus wavelength through an illumination fiber of the falloposcope while imaging light at fluorescence emission wavelength through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue. Then the sampling wire is used to collect cells from the suspect tissue for karyotype and other analysis.

A system for treating abnormal muscle activity via energy application includes a catheter, an electrode assembly including a plurality of electrodes, a processor configured to receive signals associated with intrinsic tissue activity sensed by the plurality of electrodes, the processor determining a location of a target tissue to be treated based on the sensed intrinsic activity, and a stimulator configured to transmit energy to at least one of the plurality of electrode located at the target tissue.

An intrauterine pressure-sensing catheter for detecting pressure changes within the uterus of a patient is disclosed having a tube with a primary lumen extending from a proximal end to a distal end of the elongate tube. A monitor lumen is positioned within the elongate tube between the primary lumen and a wall of the elongate tube and extends from a proximal end of the elongate tube to a distal end of the elongate tube. A compliant balloon is disposed about an exterior of the elongate tube adjacent a distal end tip. A sleeve is slidably mounted on an exterior of the elongate tube and disposed over the compliant balloon during insertion of the catheter within the patient. The distal end tip is configured to prevent movement of the sleeve over the tip and is further configured to provide a zone of protection for the compliant balloon.

A medical tool comprises: an elongate shaft comprising a wall and at least one inner core. The shaft is constructed and arranged to perform an image enhancing function selected from the group consisting of: minimize image distortion caused by the medical tool; reduce image scatter caused by the medical tool; reduce image noise caused by the medical tool; reduce image degradation caused by the medical tool; enhance visualization of the medical tool within the medical image; and combinations thereof. Systems comprising the medical tool and an imaging device are also provided.

An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in a patient's urologic, digestive, reproductive, cardiovascular, neurological or pulmonary system. Measurement transducers are installed in a housing connectable to multiple preselected medical catheters. The transducers detect bodily functions that are transmitted to the preselected catheter from within the body. The transducers, housing, electrical interface and signal processing electronics are positioned outside the body.