There is provided a new apparatus, system, and method of use for laser speckle imaging that allows for omni-directional viewing. The omni-directional viewing can include a reflector and switches configured for switching the illumination on the luminal tissue such that the light reflected from the luminal tissue at any given time is reflected from one or more substantially non-overlapping sections of a luminal tissue. This apparatus may be particularly useful for tissue analysis such as analysis of vulnerable plaque.

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

A multimodal intravascular catheter system includes a catheter with an optical channel and an electrical channel. A distal end of the catheter includes an optical element and an ultrasonic transducer, which are oriented orthogonally to a rotational axis of the catheter. A motor drive unit (MDU) is coupled to a proximal end of the catheter and includes a drive motor to rotate the catheter. The optical channel directs light from a pulsed UV laser source to the optical element, and returns an optical fluorescence signal from the optical element. A photodetector converts the returned optical fluorescence signal into an electrical fluorescence signal. An intravascular ultrasound (IVUS) processor is coupled to the ultrasonic transducer through the electrical channel, wherein the IVUS processor generates a drive signal for the ultrasound transducer, and processes echo information returned from the ultrasound transducer. Finally, a digitizer samples the electrical fluorescence signal and associated echo information.

Described herein are systems and methods for deploying and recording electrophysiologic signals from electrode arrays located within the dura mater of the brain. The dura matter includes layers of connective tissue, or membrane, that surround the brain and spinal cord. The present disclosure relates to an endovascular electrode system deployed within the blood vessels located between layers of the dura mater, including, for example, the middle meningeal artery and its branches.

In part, the disclosure relates to systems and methods to assess stent/scaffold expansion in a vessel on an expedited time scale after stent/scaffold placement and expansion. In one embodiment, the method generates a first representation of a stented segment of the blood vessel indicative of a level of stent expansion; determines using the detected stent struts, a first end of the stent and a second end of the stent; and generate a second representation of the segment of the blood vessel by interpolating a lumen profile using an offset distance from the first end and the second end.

A delivery system for an intracorporeal device includes a sheath defining one or more lumens shaped to receive a delivery catheter or shaft and a guidewire. The system may include a delivery shaft having a distal coupling feature adapted to releasably couple with a proximal coupling feature of the intracorporeal device. The delivery system may further include a hub through which the delivery shaft and guidewire are passed. The delivery shaft may be coupled to a feature, such as a knob, that enables manipulation of the delivery shaft to decouple the distal fixation feature from the proximal fixation feature of the intracorporeal device in order to deploy the intracorporeal device within a patient.

A catheter, such as a fractional flow reserve catheter, includes an elongate shaft having a proximal end optionally coupled to a handle or luer fitting and a distal end having a distal opening. A pressure sensing wire extends to the distal portion of the elongate shaft to be coupled to a pressure sensor mounted on the distal end for measuring a pressure of a fluid within lumen of vessel. The pressure sensor wire is disposed within a pocket formed adjacent to the pressure sensor thereby minimizing the profile of the catheter. Bending or flexing stress or strain experienced by a pressure sensor mounted to a fractional flow reserve catheter when tracking the catheter through the vasculature creates a distortion of the sensor resulting in an incorrect pressure reading or bend error. In order to isolate the sensor from bending or flexing stress and strain, the sensor is mounted so that the sensor is spaced apart from the elongate shaft of the catheter.

An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.

Embodiments described herein relate to an implantable device that include an inductor coil, a storage capacitor, active circuitry, and a sensor, but doesn't include an electrochemical cell, and methods for use therewith. During first periods of time, the storage capacitor accumulates and stores energy received via the inductor coil from a non-implanted device. During second periods of time, interleaved with the first periods of time, and during which energy is not received from the non-implanted device, the active circuitry of the implantable device is powered by the energy stored on the storage capacitor and is used to perform at least one of a plurality of predetermined operations of the implantable device, including, e.g., obtaining a sensor measurement from the sensor of the implantable device, transmitting a communication signal including a sensor measurement to the non-implanted device, and/or receiving a communication signal from the non-implanted device.

The present invention relates to a device for treating an aneurysm of a human or mammal patient, wherein the aneurysm may self expand, leading to the aneurysm bursting with high risk for death of the human or mammal patient. The device is provided with an implantable member to be placed in connection with the outside of a blood vessel having the aneurysm, and to exercise a pressure on the outside of the blood vessel having the aneurysm, a measuring device or sensor for measuring or sensing an expansion of the aneurysm, and a monitoring system for monitoring the expansion of the aneurysm based on a signal received from the measuring device or sensor.