A device for continuously monitoring glucose levels in a patient is disclosed. The device includes a glucose electronics assembly and a glucose lead assembly in electrical communication with the glucose electronics assembly. The glucose electronics assembly is configured to be positioned in the subcutaneous tissue and the glucose lead assembly is configured to be positioned in a vessel of the patient. The glucose lead assembly has a central shaft, a first electrode in physical communication with the central shaft, a second electrode in physical communication with the central shaft, a third electrode in physical communication with the central shaft and a positioning element configured to have an undeployed state and a deployed state. In the undeployed state, the positioning element is substantially linear, and in the deployed state, the positioning element extends away from the central shaft.

An implant unit configured for implantation into a body of a subject is provided. The implant unit may include a flexible carrier unit including a central portion and two elongated arms extending from the central portion, an antenna, located on the central portion, configured to receive a signal, at least one pair of electrodes arranged on a first elongated arm of the two elongated arms. The at least one pair of electrodes may be adapted to modulate a first nerve. The elongated arms of the flexible carrier may be configured to form an open ended curvature around a muscle with the nerve to be stimulated within an arc of the curvature.

Implantable device for measuring the glucose concentration of a body fluid when implanted, the implantable device comprising a glucose measurement unit, the glucose measurement unit comprising a first light source configured to emit light towards a light transmissive part of a housing of the device and a first optical sensor configured to detect light returned through the light transmissive part from the first light source, and output a first electrical signal based on the detected light; and a wireless communication module configured to wirelessly communicate with an external wireless communication device, wherein the wireless communication module is configured to wirelessly transmit a signal based on the first electrical signal to the external wireless communication device.

In one embodiment, a sensor includes a capsule having a cavity and a sheath, a transducer coupled to electronic circuitry in the cavity, and a clip outside the capsule. The capsule and the clip are configured to hold in vivo an object within an opening between the capsule and the clip. The transducer is configured to detect an incoming signal indicative of a physiological parameter of the object being held, and the electronic circuitry is configured to wirelessly transmit a signal containing information about the physiological parameter obtained from the incoming signal. The sensor is part of a measurement system to measure the physiological parameter. Another embodiment describes a method using the measurement system.

An image diagnosis catheter includes a rotatable drive shaft, a sheath into which the drive shaft is inserted, a housing provided at a distal end of the drive shaft and accommodating an ultrasound transmitter and receiver and an optical transmitter and receiver, and a positioning member fixed to the housing and fixing a relative position of the optical transmitter and receiver with respect to the ultrasound transmitter and receiver.

A sensor apparatus includes at least one substrate layer of an elastically deformable material, the substrate layer extending longitudinally between spaced apart ends thereof. A conductive layer is attached to and extends longitudinally between the spaced apart ends of the at least one substrate layer. The conductive layer includes an electrically conductive material adapted to form a strain gauge having an electrical resistance that varies based on deformation of the conductive layer in at least one direction.

Systems, devices, and methods for delivering laser energy to a target in an endoscopic procedure are disclosed. An exemplary method comprises providing a first laser pulse train and a different second laser pulse train emitting from a distal end of an endoscope and incident on a target. The first laser pulse train has a first laser energy level, and the second laser pulse train has a second laser energy level higher than the first laser energy level. In an example, the first laser pulse train is used to form cracks on a surface of a calculi structure, and the second laser pulse train causes fragmentation of the calculi structure after the cracks are formed.

A catheter system may include a catheter lumen, first and second electrodes, and a sensor in communication with the first and second electrodes. The sensor may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel. Other catheter systems may include a catheter lumen and a sensing chip coupled to the catheter lumen. The sensing chip may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel.

Systems and methods of controlling a device using detected changes in a neural-related signal of a subject are disclosed. In one embodiment, a method of controlling a device or software application comprises detecting a first change in a neural-related signal of a subject, detecting a second change in the neural-related signal, and transmitting an input command to the device upon or following the detection of the second change in the neural-related signal. The neural-related signal can be detected using a neural interface implanted within a brain of the subject.

Embodiments of the disclosure include apparatuses, systems, and methods for a catheter with a single element for both imaging and interventions. The catheter may have a distal tip which is positionable in a patient (e.g., in a lumen of a vessel). The distal tip may have an optical component which includes both a reflecting surface and a tapered distal end. The reflecting surface may redirect light (e.g., light received along an optical fiber of the catheter) into an imaging beam, which may be directed to a wall of the vessel. The tapered distal end may be a crossing tool used to cross an occluded or partially-occluded section of the vessel. In some embodiments, the reflecting surface and tapered distal end may be the same surface of the optical component. A low refractive index optical filler may be provided to reduce image artifacts at the imaging interface with the patient's fluid and tissue.