Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Various examples are described for needle alignment for wearable biosensors. One example device includes a housing comprising an upper portion and a lower portion, the housing defining a cavity between the upper portion and the lower portion and configured to be worn on a wearer's skin, wherein: the upper portion defines a first opening extending through the upper portion to the cavity, and the lower portion defines a second opening extending through the lower portion to the cavity, the cavity establishing a substantially unobstructed pathway including the first opening and the second opening to enable an insertion needle to be inserted through the housing; and a needle guide extending into and along a portion of the pathway and aligned with a sensor wire to enable alignment between the insertion needle and the sensor wire.

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

A subcutaneous analyte sensor applicator includes an inserter module and a sensor module. The inserter module includes an applicator housing, a deployment button, and a pre-loaded insertion assembly completely disposed and secured within the button and partially disposed within the applicator housing when the button is in an initial, loaded position on the applicator housing. The insertion assembly includes an assembly housing, and a biasing element and a needle assembly disposed within the assembly housing chamber where the biasing element is in a compressed state. The sensor module includes a sensor lower housing releasably connected to the applicator housing, a sensor upper housing removably retained against the insertion assembly housing and spaced from the sensor lower housing, and an electro-sensor assembly disposed within the sensor upper housing where a sensor is temporarily disposed within a needle of a needle assembly when the applicator system is in the initial pre-loaded position.

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

A surgical system for intra-operative and post-operative measurement of motion and position of the musculoskeletal system. The surgical system comprises a surgical navigation system configured to support the installation of at least one prosthetic component. The surgical navigation system measures motion and position of the musculoskeletal system during surgery. Holes are drilled in a first bone and a second bone of the musculoskeletal system to retain tracking devices of the surgical navigation system. Leaving the holes in the first bone and the second bone after completing the surgery can introduce stress risers that could reduce bone integrity. The surgical system includes a first implantable device and a second implantable device each having anchors corresponding to the holes of the first bone and the second bone. The first implantable device and the second implantable device each has an IMU to measure motion and position post-operatively. The anchors are configured to reduce stress risers.

The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting therethrough the sensor and containing a part of the sensor, and a containing indentation containing the signal output end, wherein the containing indentation has a surrounding wall kept apart from the signal output end to define a space.

Disclosed herein is a urine collection bag, system, and methods directed to automated measurement of a quantity of urine. The urine collection system can include the urine collection bag, a catheter, and flexible drainage tubing. The urine collection bag can include a collection area, force sensors, and circuitry configured to determine the volume of urine in the collection area based on pressure or weight measured by the force sensors, and the specific gravity of the urine. The catheter may include a small female external catheter (FEC) with an opening on a top side, a wicking catheter with a wicking area on a top side, a finger-mountable catheter, or a male external catheter (MEC). The tubing may be secured to a patient's leg with a stabilization device or a fabric strap. The catheter can remain on a patient while the patient stands or walks.

Systems and methods for monitoring sleep are disclosed. According to an aspect, a method includes emitting light into tissue. The method also includes detecting light backscattered from the tissue. Further, the method includes determining a sleep pattern based on the backscattered light.

A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of steel balls. The sensing member is removably inserted into the socket. The steel balls are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the steel balls is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.