Wireless, variable inductance and resonant circuit-based vascular monitoring devices, systems, methodologies, and techniques, including specifically configured anchoring structures for same, are disclosed that can be used to assist healthcare professionals in predicting, preventing, and diagnosing various heart-related and other health conditions.

A system and method are provided for determining a pressure associated with a lumen of a body. A wireless sensor is positioned in the lumen of the body. The sensor comprises an LC resonant circuit having a resonant frequency configured to vary in response to changes in pressure in the lumen. One or more sensor calibration parameters are stored at an external base unit. The external based unit generates and transmits an energizing signal. A ring down response is received from the wireless sensor. The system and method determine the resonant frequency of the LC resonant circuit from the ring down response and calculate the pressure in the lumen from the resonant frequency of the LC resonant circuit utilizing the one or more sensor calibration parameters associated with the LC resonant circuit.

An implant sized and shaped to be endovascularly delivered to the middle meningeal artery includes a carrier that carries a payload between first and second ends thereof. An anchor mechanism associated with the implant transitions into a swollen state in response to exposure to bodily fluids. In the swollen state, said anchor mechanism anchors the implant to the middle meningeal artery. Before or during the transition, the anchor mechanism permits endovascular delivery of the implant to the middle meningeal artery.

Monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. In some implantable device embodiments, the device includes a polymer layer comprising a material that changes volume in response to varying glucose concentrations of the aqueous humor. A pressure sensor in the device can detect the changes in volume. In some implantable device embodiments, the device includes electrodes for determining the glucose concentration.

In one aspect, an apparatus for monitoring a physiological condition of a patient is disclosed. The apparatus includes a body having an attachment portion configured to be inserted into the skin of a patient to affix the body to the patient. The apparatus includes a sensor coupled to the body that is configured to generate sensor data corresponding to a physiological condition of the patient when the body is secured to the skin of the patient. The apparatus further includes a reference sensor that is remote from the sensor coupled to the body and is configured to engage an outer surface of skin to generate reference data against which the sensor data is compared.

A subcutaneously implantable device includes a housing, a clip attached to the housing, and an electrode. The clip is configured to move between an open position and a closed position to increase or decrease an opening between the housing and the clip to anchor the device to a muscle, a bone, and/or a first tissue. The electrode is configured to contact an organ, a nerve, the first tissue, and/or a second tissue. Circuitry in the housing is in electrical communication with the electrode and is configured to provide monitoring, therapeutic, and/or diagnostic capabilities with respect to the organ, the nerve, the first tissue, and/or the second tissue.

Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.

A dialysis catheter with an elongate body has a distal end defining blood removal and return ports communicating with internal blood removal and return lumens extending through the elongate body. A sensing pathway is disposed in or on the elongate body. A vascular dimension sensor is provided to dynamically measure changes in dimension of the SVC or IVC during dialysis. The sensor communicates with a control system and may be controlled or positioned via the communication pathway of the catheter body. Systems disclosed included integrated closed-loop treatment based on monitored vascular dimension input. Methods included patient optimized treatments incorporating treatment modulation based on dynamic vascular dimension monitoring.

Systems and methods for delivering an implantable sensor assembly into a vascular structure. The sensor assembly is capable of detecting one or more physiological parameters of a patient and generating sensor data. The one or more physiological parameters may be indicative of blood flow through the vascular structure. The sensor assembly may wirelessly transmit the sensor data to a receiver.

Some embodiments of pacing systems employ wireless electrode assemblies to provide pacing therapy. The wireless electrode assemblies may wirelessly receive energy via an inductive coupling so as to provide electrical stimulation to the surrounding heart tissue. In certain embodiments, the wireless electrode assembly may include one or more biased tines that shift from a first position to a second position to secure the wireless electrode assembly into the inner wall of the heart chamber.